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PRKAB2 — RELA

Text-mined interactions from Literome

Cacicedo et al., Biochem Biophys Res Commun 2004 : AMPK inhibits fatty acid induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells ... The increases in NF-kappaB activation and VCAM-1 expression caused by palmitate were markedly inhibited by co-incubation with the AMPK activator AICAR and, where studied, by expression of a constitutively active AMPK ... Likewise, AMPK activation inhibited the increase in NF-kappaB reporter gene expression observed in HUVEC incubated with TNF-alpha ... The results suggest that AMPK inhibits the activation of NF-kappaB caused by both palmitate and TNF-alpha
Hattori et al., Hypertension 2006 : A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ), dose-dependently inhibited TNF-alpha- and interleukin-1beta induced NF-kappaB reporter gene expression ... In light of these findings, we suggest that metformin attenuates the cytokine induced expression of proinflammatory and adhesion molecule genes by inhibiting NF-kappaB activation via AMPK activation
Jhun et al., Biochem Biophys Res Commun 2006 : Moreover, inhibition of AMPK suppressed transcriptional activation of NF-AT and AP-1, but not NF-kappaB , in PMA/Io activated Jurkat cells
Li et al., J Cell Biochem 2007 (Cardiomegaly...) : Furthermore, long-term AMPK activation attenuated protein synthesis, diminished calcineurin-nuclear factor of activated T cells ( NFAT ) and nuclear factor kappaB (NF-kappaB) signaling in pressure overload induced hypertrophic hearts ... Our in vitro experiments further proved that activation of AMPK by infection of AdAMPK blocked cardiac hypertrophy and NFAT, NF-kappaB , and MAPK signal pathways
Yoon et al., Biochem Biophys Res Commun 2008 (Glioma) : Finally, we showed that inhibition of AMPK reduced DNA binding and transcriptional activation of nuclear factor-kappaB (NF-kappaB) in KA-treated cells
Hattori et al., FEBS Lett 2008 : HMW adiponectin by itself was found to modestly activate NF-kappaB , which was significantly enhanced by inhibition of AMPK/eNOS activation
Wang et al., J Cell Physiol 2010 (Cardiomegaly) : Pharmacological activator of AMPK could inhibit AngII induced NF-kappaB translocation, and inhibitor of AMPK or a dominant negative AMPK adenovirus suppressed gAd mediated inhibition of I-kappaB phosphorylation and NF-kappaB activation ... Our data indicate that gAd inhibits cardiac hypertrophic signaling through AMPK mediated suppression of NF-kappaB activation
Łabuzek et al., Neurotoxicology 2010 : Furthermore, we found that the effects of AICAR on IL-6 and TNF-alpha ( 12, 24h ) release and on the expression of iNOS and NF-kappaB p65 are not AMPK dependent because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010 (Inflammation) : However, compound C down-regulated IL-1 beta, IL-6 and TNF alpha release, NO, ROS production, and AMPK activity, diminished NF-kappaB and HIF-1 alpha expression, as well as increased arginase I expression in lipopolysaccharide (LPS) stimulated microglia
Wang et al., Circ Res 2010 : Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of AMPK activity increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ), NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB ( p50 and p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect
Liu et al., J Biol Chem 2010 : Furthermore, AMPK activation significantly enhanced IkappaBalpha kinase activation, NF-kappaB nuclear translocation, and DNA binding activity of NF-kappaB
Yang et al., J Biol Chem 2010 (Insulin Resistance...) : Chromatin immunoprecipitation and luciferase reporter assays show that activation of AMPK by CA-alpha1 in macrophages significantly inhibits LPS- or FFA induced NF-kappaB signaling
Hattori et al., Diabetologia 2010 : Liraglutide induced enhancement of nitric oxide production and suppression of NF-kappaB activation were attenuated by the AMP activated protein kinase (AMPK) inhibitor compound C or AMPK ( also known as PRKAA1 ) small interfering RNA