UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to SMAD2

EP300 — SMAD2

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: SMAD2 → Complex of EP300-SMAD2 (directlyIncreases, EP300/SMAD2 Activity) Ross et al., EMBO J 2006 *
Evidence: We demonstrate that Smad2-mediated transcription requires the histone acetyltransferase, p300. Smad2-recruited p300 exhibits an altered substrate specificity, specifically acetylating nucleosomal histone H3 at lysines 9 and 18, and these modifications are also detected on an endogenous Smad2-dependent promoter in a ligand-induced manner.
BioCarta tgf beta signaling pathway: SMAD2/SMAD2/SMAD4/p300/CBP complex (SMAD2-CREBBP-EP300-SMAD4) → SnoN (SKIL) (transcription, activates)
BioCarta tgf beta signaling pathway: SMAD2/SMAD2/SMAD4 complex (SMAD4-SMAD2) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
BioCarta tgf beta signaling pathway: SMAD2/SMAD2/SMAD4 complex (SMAD4-SMAD2) → SMAD2/SMAD2/SMAD4/p300/CBP complex (SMAD2-CREBBP-EP300-SMAD4) (modification, collaborate)
BioCarta tgf beta signaling pathway: p300/CBP complex (CREBBP-EP300) → SMAD2/SMAD2/SMAD4/p300/CBP complex (SMAD2-CREBBP-EP300-SMAD4) (modification, collaborate)
KEGG TGF-beta signaling pathway: Complex of SMAD2-SMAD3-SMAD4 → Complex of CREBBP-EP300-SP1 (protein-protein, activation)
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: Cbp/p300/SNIP1 complex (EP300_CREBBP-SNIP1) → SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) (modification, inhibits)
Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: Cbp/p300/PIAS3 complex (EP300_CREBBP-PIAS3) → SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) (modification, activates)
Long et al., Proc Natl Acad Sci U S A 2004
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD2/SMAD2/SMAD4/FOXH1 complex (SMAD2-SMAD4-FOXH1) → p300 (EP300) (modification, collaborate) Bai et al., Nat Cell Biol 2002
Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: EP300 — SMAD2 Janknecht et al., Genes Dev 1998
IRef Bind_translation Interaction: EP300 — SMAD2 (coimmunoprecipitation) Janknecht et al., Genes Dev 1998
IRef Biogrid Interaction: EP300 — SMAD2 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
IRef Biogrid Interaction: EP300 — SMAD2 (physical association, affinity chromatography technology) Wotton et al., Cell 1999
IRef Biogrid Interaction: EP300 — SMAD2 (physical association, affinity chromatography technology) Pessah et al., Proc Natl Acad Sci U S A 2001 *
IRef Biogrid Interaction: EP300 — SMAD2 (physical association, affinity chromatography technology) Furumatsu et al., J Biol Chem 2005 *
Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
IRef Hprd Interaction: EP300 — SMAD2 (in vivo) Mori et al., Blood 2001 *, Pessah et al., Proc Natl Acad Sci U S A 2001 *
IRef Intact Interaction: EP300 — SMAD2 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
IRef Ophid Interaction: EP300 — SMAD2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
IRef Ophid Interaction: EP300 — SMAD2 (aggregation, confirmational text mining) Mori et al., Blood 2001 *