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IL10 — SP1
Text-mined interactions from Literome
Tone et al., J Immunol 2000
:
The
requirement for
Sp1 and Sp3 in transcription of
IL-10 was confirmed using Drosophila SL2 cells, which lack endogenous Sp factors ... These results suggest that the transcription of
IL-10 is positively
regulated by both
Sp1 and Sp3
Ikeda et al., J Leukoc Biol 2002
:
Furthermore,
IL-10 suppressed lipopolysaccharide (LPS) induced NF-kappaB binding but not
Sp-1
Liu et al., J Immunol 2003
:
These results suggested that the interaction between
Sp1 and C/EBPbeta and delta induced by LPS cooperatively
activated expression of the
IL-10 gene
Khadaroo et al., Shock 2004
(Shock, Hemorrhagic) :
Reduced
IL-10 transcription was not
caused solely by impaired nuclear translocation of STAT3 and
Sp1/Sp3 transcription factors because LPS induced nuclear translocation of these factors was augmented by antecedent shock
Gee et al., J Immunol 2007
:
Taken together, our results suggest that extracellular HIV-Tat induced
IL-10 transcription in primary human monocytes is
regulated by CREB-1 and
Sp-1 transcription factors through the activation of calmodulin/CaMK-II dependent p38 MAPK
Wang et al., J Biol Chem 1995
:
Several other transcription factors including NF-IL-6, AP-1, AP-2, GR, CREB, Oct-1, and
Sp-1 are not
affected by
IL-10