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Chadjichristos et al., J Biol Chem 2003
:
Moreover, IL-1 beta increased steady-state levels of Sp1 and Sp3 mRNAs, whereas it enhanced Sp3 protein expression and inhibited Sp1 protein biosynthesis
McDowell et al., Cytokine 2005
:
Human interleukin-1 alpha gene expression is regulated by Sp1 and a transcriptional repressor
Enya et al., J Leukoc Biol 2008
(Melanoma) :
The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells ... These results indicate that the reduction in the activity and interaction of HDAC1 with Sp1 are critical for the constitutive IL-1 alpha gene expression