◀ Back to XRCC5

ADCYAP1 — XRCC5

Text-mined interactions from Literome

Romano et al., J Biol Chem 2003 : By using pull-down experiments, we show that VIP and PACAP38 preferentially activate Rap1 , whereas thyrotropin releasing hormone (TRH) and epidermal growth factor (EGF) mainly activate Ras GTPase
Obara et al., J Neurochem 2007 : We show that both Ras and Rap1 can be activated by cAMP or PACAP via protein kinase (PKA) dependent mechanisms
Ravni et al., Mol Pharmacol 2008 : PACAP signaling to neuritogenesis was also impaired by dominant negative Rap1 expression but was not affected by inhibition of protein kinase C ( PKC ), indicating a G-protein coupled receptor mediated differentiation pathway distinct from the one activated by receptor tyrosine kinase ligands such as nerve growth factor (NGF), that involves both Rap1 and PKC
Lastres-Becker et al., Mol Cell Neurosci 2008 : PACAP also activates the small GTPases Rap1 and Ras, but either activation of Rap1 alone by selective stimulation of the guanine nucleotide exchange factor Epac, or expression of a constitutively active form of Ras, do not induce GFAP gene expression
Zhang et al., Cell Signal 2009 (MAP Kinase Signaling System) : Here, we show that PACAP recruits Rap1 into caveolin enriched membrane subdomains in PC12 cells and activates Rap1 , nuclear ERK1/2, Elk-1 and CREB in a caveolae dependent manner