ID:ATG4B_HUMAN DESCRIPTION: RecName: Full=Cysteine protease ATG4B; EC=3.4.22.-; AltName: Full=AUT-like 1 cysteine endopeptidase; AltName: Full=Autophagin-1; AltName: Full=Autophagy-related cysteine endopeptidase 1; AltName: Full=Autophagy-related protein 4 homolog B; Short=hAPG4B; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling. ENZYME REGULATION: Inhibited by N-ethylmaleimide. INTERACTION: O95166:GABARAP; NbExp=8; IntAct=EBI-712014, EBI-712001; Q9H0R8:GABARAPL1; NbExp=7; IntAct=EBI-712014, EBI-746969; P60520:GABARAPL2; NbExp=5; IntAct=EBI-712014, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=6; IntAct=EBI-712014, EBI-373144; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. SIMILARITY: Belongs to the peptidase C54 family. SEQUENCE CAUTION: Sequence=BAA76787.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86110.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y4P1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
