ID:BIRC7_HUMAN DESCRIPTION: RecName: Full=Baculoviral IAP repeat-containing protein 7; EC=6.3.2.-; AltName: Full=Kidney inhibitor of apoptosis protein; Short=KIAP; AltName: Full=Livin; AltName: Full=Melanoma inhibitor of apoptosis protein; Short=ML-IAP; AltName: Full=RING finger protein 50; Contains: RecName: Full=Baculoviral IAP repeat-containing protein 7 30kDa subunit; Short=Truncated livin; Short=p30-Livin; Short=tLivin; FUNCTION: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing. SUBUNIT: Binds to CASP9. Interaction with DIABLO/SMAC via the BIR domain disrupts binding to CASP9 and apoptotic suppressor activity. Interacts with TAB1. In vitro, interacts with CASP3 and CASP7 via its BIR domain. INTERACTION: P55211:CASP9; NbExp=5; IntAct=EBI-517623, EBI-516799; Q9NR28:DIABLO; NbExp=6; IntAct=EBI-517623, EBI-517508; O43464:HTRA2; NbExp=2; IntAct=EBI-517623, EBI-517086; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Golgi apparatus. Note=Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis. TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. DOMAIN: The RING domain is essential for autoubiquitination. PTM: Autoubiquitinated and undergoes proteasome-mediated degradation. PTM: The truncated protein (tLivin) not only loses its anti- apoptotic effect but also acquires a pro-apoptotic effect. SIMILARITY: Belongs to the IAP family. SIMILARITY: Contains 1 BIR repeat. SIMILARITY: Contains 1 RING-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CA5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004842 ubiquitin-protein transferase activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0005515 protein binding GO:0016740 transferase activity GO:0019899 enzyme binding GO:0030414 peptidase inhibitor activity GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0046872 metal ion binding
Biological Process: GO:0006915 apoptotic process GO:0007257 activation of JUN kinase activity GO:0009966 regulation of signal transduction GO:0010466 negative regulation of peptidase activity GO:0016567 protein ubiquitination GO:0042127 regulation of cell proliferation GO:0043066 negative regulation of apoptotic process GO:0070247 regulation of natural killer cell apoptotic process GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:0090307 mitotic spindle assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
