ID:CAR11_HUMAN DESCRIPTION: RecName: Full=Caspase recruitment domain-containing protein 11; AltName: Full=CARD-containing MAGUK protein 1; Short=Carma 1; FUNCTION: Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. SUBUNIT: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail). SUBCELLULAR LOCATION: Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. TISSUE SPECIFICITY: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL- 60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLaS3, MOLT-4, A-549 and G431 cells. PTM: Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCB and PRKCQ leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling (By similarity). SIMILARITY: Contains 1 CARD domain. SIMILARITY: Contains 1 guanylate kinase-like domain. SIMILARITY: Contains 1 PDZ (DHR) domain. CAUTION: Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART. SEQUENCE CAUTION: Sequence=AAG53402.1; Type=Erroneous initiation; Sequence=AAI11720.2; Type=Erroneous initiation; Sequence=AAQ96893.1; Type=Erroneous gene model prediction; Sequence=EAL23962.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BXL7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001819 positive regulation of cytokine production GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002377 immunoglobulin production GO:0007165 signal transduction GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0030183 B cell differentiation GO:0030890 positive regulation of B cell proliferation GO:0031295 T cell costimulation GO:0038095 Fc-epsilon receptor signaling pathway GO:0038202 TORC1 signaling GO:0042100 B cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042981 regulation of apoptotic process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0045061 thymic T cell selection GO:0045086 positive regulation of interleukin-2 biosynthetic process GO:0045577 regulation of B cell differentiation GO:0045580 regulation of T cell differentiation GO:0046037 GMP metabolic process GO:0046649 lymphocyte activation GO:0046710 GDP metabolic process GO:0048872 homeostasis of number of cells GO:0050776 regulation of immune response GO:0050852 T cell receptor signaling pathway GO:0050870 positive regulation of T cell activation GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0070970 interleukin-2 secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
