ID:CASP5_HUMAN DESCRIPTION: RecName: Full=Caspase-5; Short=CASP-5; EC=3.4.22.58; AltName: Full=ICE(rel)-III; AltName: Full=Protease ICH-3; AltName: Full=Protease TY; Contains: RecName: Full=Caspase-5 subunit p20; Contains: RecName: Full=Caspase-5 subunit p10; Flags: Precursor; FUNCTION: Mediator of programmed cell death (apoptosis). CATALYTIC ACTIVITY: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. TISSUE SPECIFICITY: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. INDUCTION: Up-regulated by bacterial lipopolysaccharides (LPS). PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism. SIMILARITY: Belongs to the peptidase C14A family. SIMILARITY: Contains 1 CARD domain. SEQUENCE CAUTION: Sequence=AAA75172.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH74994.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI13407.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=ABF47103.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG59257.1; Type=Frameshift; Positions=10; Sequence=CAA64450.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp5/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47986 - DEATH domain 52129 - Caspase-like
ModBase Predicted Comparative 3D Structure on P51878
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004197 cysteine-type endopeptidase activity GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0016787 hydrolase activity GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process: GO:0006508 proteolysis GO:0006915 apoptotic process GO:0021762 substantia nigra development GO:0042981 regulation of apoptotic process GO:0050727 regulation of inflammatory response GO:0071260 cellular response to mechanical stimulus GO:0097194 execution phase of apoptosis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
