Human Gene CCL22 (ENST00000219235.5_4) from GENCODE V47lift37
  Description: C-C motif chemokine ligand 22 (from RefSeq NM_002990.5)
Gencode Transcript: ENST00000219235.5_4
Gencode Gene: ENSG00000102962.5_7
Transcript (Including UTRs)
   Position: hg19 chr16:57,392,695-57,400,101 Size: 7,407 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:57,392,729-57,397,500 Size: 4,772 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:57,392,695-57,400,101)mRNA (may differ from genome)Protein (93 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CCL22_HUMAN
DESCRIPTION: RecName: Full=C-C motif chemokine 22; AltName: Full=CC chemokine STCP-1; AltName: Full=MDC(1-69); AltName: Full=Macrophage-derived chemokine; AltName: Full=Small-inducible cytokine A22; AltName: Full=Stimulated T-cell chemotactic protein 1; Contains: RecName: Full=MDC(3-69); Contains: RecName: Full=MDC(5-69); Contains: RecName: Full=MDC(7-69); Flags: Precursor;
FUNCTION: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.
PTM: The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.
SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
WEB RESOURCE: Name=Wikipedia; Note=CCL22 entry; URL="http://en.wikipedia.org/wiki/CCL22";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CCL22
Diseases sorted by gene-association score: atopic dermatitis (23), eosinophilic pneumonia (17), dermatitis (13), necatoriasis (11), apple allergy (10), mycosis fungoides (10), peanut allergy (8), atopic keratoconjunctivitis (8), stevens-johnson syndrome/toxic epidermal necrolysis (6), contact dermatitis (6), lymphadenitis (5), pulmonary fibrosis, idiopathic (5), primary syphilis (4), asthma (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 298.08 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 307.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.9034-0.174 Picture PostScript Text
3' UTR -852.002601-0.328 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000827 - Chemokine_CC_CS
IPR002473 - Chemokine_CXCL8/IL8
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

ModBase Predicted Comparative 3D Structure on O00626
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0008009 chemokine activity
GO:0048020 CCR chemokine receptor binding

Biological Process:
GO:0002548 monocyte chemotaxis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0009615 response to virus
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030593 neutrophil chemotaxis
GO:0031640 killing of cells of other organism
GO:0043547 positive regulation of GTPase activity
GO:0048247 lymphocyte chemotaxis
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071346 cellular response to interferon-gamma
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  LP896023 - Sequence 887 from Patent EP3253886.
AK311970 - Homo sapiens cDNA, FLJ92243, Homo sapiens chemokine (C-C motif) ligand 22 (CCL22), mRNA.
U83171 - Human macrophage-derived chemokine precursor (MDC) mRNA, complete cds.
U83239 - Human CC chemokine STCP-1 mRNA, complete cds.
BC027952 - Homo sapiens chemokine (C-C motif) ligand 22, mRNA (cDNA clone MGC:34554 IMAGE:5220453), complete cds.
CU693342 - Synthetic construct Homo sapiens gateway clone IMAGE:100017896 5' read CCL22 mRNA.
KJ897526 - Synthetic construct Homo sapiens clone ccsbBroadEn_06920 CCL22 gene, encodes complete protein.
AB590299 - Synthetic construct DNA, clone: pFN21AE1469, Homo sapiens CCL22 gene for chemokine (C-C motif) ligand 22, without stop codon, in Flexi system.
DQ890922 - Synthetic construct clone IMAGE:100003552; FLH167424.01X; RZPDo839A0290D chemokine (C-C motif) ligand 22 (CCL22) gene, encodes complete protein.
DQ893311 - Synthetic construct clone IMAGE:100005941; FLH196022.01X; RZPDo839C02154D chemokine (C-C motif) ligand 22 (CCL22) gene, encodes complete protein.
DQ894072 - Synthetic construct Homo sapiens clone IMAGE:100008532; FLH167423.01L; RZPDo839A0289D chemokine (C-C motif) ligand 22 (CCL22) gene, encodes complete protein.
DQ896625 - Synthetic construct Homo sapiens clone IMAGE:100011085; FLH196018.01L; RZPDo839C02153D chemokine (C-C motif) ligand 22 (CCL22) gene, encodes complete protein.
EU176526 - Synthetic construct Homo sapiens clone IMAGE:100011643; FLH264003.01L; RZPDo839C10245D chemokine (C-C motif) ligand 22 (CCL22) gene, encodes complete protein.
MS906523 - Sequence 77 from Patent WO2017059902.
MS909329 - Sequence 77 from Patent WO2017060314.
MS906526 - Sequence 80 from Patent WO2017059902.
MS909332 - Sequence 80 from Patent WO2017060314.
MS906522 - Sequence 76 from Patent WO2017059902.
MS909328 - Sequence 76 from Patent WO2017060314.
MS906520 - Sequence 74 from Patent WO2017059902.
MS909326 - Sequence 74 from Patent WO2017060314.
MS906519 - Sequence 73 from Patent WO2017059902.
MS909325 - Sequence 73 from Patent WO2017060314.
MS906521 - Sequence 75 from Patent WO2017059902.
MS909327 - Sequence 75 from Patent WO2017060314.
MS906530 - Sequence 84 from Patent WO2017059902.
MS909336 - Sequence 84 from Patent WO2017060314.
MS906524 - Sequence 78 from Patent WO2017059902.
MS909330 - Sequence 78 from Patent WO2017060314.
MS906525 - Sequence 79 from Patent WO2017059902.
MS909331 - Sequence 79 from Patent WO2017060314.
JD118033 - Sequence 99057 from Patent EP1572962.
JD213517 - Sequence 194541 from Patent EP1572962.
JD463474 - Sequence 444498 from Patent EP1572962.
MS906531 - Sequence 85 from Patent WO2017059902.
MS909337 - Sequence 85 from Patent WO2017060314.
MS906529 - Sequence 83 from Patent WO2017059902.
MS909335 - Sequence 83 from Patent WO2017060314.
MS906527 - Sequence 81 from Patent WO2017059902.
MS909333 - Sequence 81 from Patent WO2017060314.
JD269284 - Sequence 250308 from Patent EP1572962.
MS906528 - Sequence 82 from Patent WO2017059902.
MS909334 - Sequence 82 from Patent WO2017060314.
JD122574 - Sequence 103598 from Patent EP1572962.
JD492443 - Sequence 473467 from Patent EP1572962.
JD426800 - Sequence 407824 from Patent EP1572962.
JD545272 - Sequence 526296 from Patent EP1572962.
JD500193 - Sequence 481217 from Patent EP1572962.
JD547933 - Sequence 528957 from Patent EP1572962.
JD328586 - Sequence 309610 from Patent EP1572962.
JD053023 - Sequence 34047 from Patent EP1572962.
JD208460 - Sequence 189484 from Patent EP1572962.
JD253233 - Sequence 234257 from Patent EP1572962.
JD417939 - Sequence 398963 from Patent EP1572962.
JD367571 - Sequence 348595 from Patent EP1572962.
JD335189 - Sequence 316213 from Patent EP1572962.
JD172498 - Sequence 153522 from Patent EP1572962.
JD307721 - Sequence 288745 from Patent EP1572962.
JD045856 - Sequence 26880 from Patent EP1572962.
JD492249 - Sequence 473273 from Patent EP1572962.
JD558600 - Sequence 539624 from Patent EP1572962.
JD198769 - Sequence 179793 from Patent EP1572962.
JD154221 - Sequence 135245 from Patent EP1572962.
JD262343 - Sequence 243367 from Patent EP1572962.
JD295670 - Sequence 276694 from Patent EP1572962.
JD295671 - Sequence 276695 from Patent EP1572962.
JD295672 - Sequence 276696 from Patent EP1572962.
JD281382 - Sequence 262406 from Patent EP1572962.
JD491961 - Sequence 472985 from Patent EP1572962.
JD513438 - Sequence 494462 from Patent EP1572962.
JD494599 - Sequence 475623 from Patent EP1572962.
JD262193 - Sequence 243217 from Patent EP1572962.
JD165354 - Sequence 146378 from Patent EP1572962.
JD213573 - Sequence 194597 from Patent EP1572962.
JD467894 - Sequence 448918 from Patent EP1572962.
JD150872 - Sequence 131896 from Patent EP1572962.
JD225413 - Sequence 206437 from Patent EP1572962.
JD356723 - Sequence 337747 from Patent EP1572962.
JD242682 - Sequence 223706 from Patent EP1572962.
JD330945 - Sequence 311969 from Patent EP1572962.
JD441629 - Sequence 422653 from Patent EP1572962.
JD329651 - Sequence 310675 from Patent EP1572962.
JD329652 - Sequence 310676 from Patent EP1572962.
JD108117 - Sequence 89141 from Patent EP1572962.
JD342305 - Sequence 323329 from Patent EP1572962.
JD480528 - Sequence 461552 from Patent EP1572962.
JD435529 - Sequence 416553 from Patent EP1572962.
JD161370 - Sequence 142394 from Patent EP1572962.
JD131866 - Sequence 112890 from Patent EP1572962.
JD356273 - Sequence 337297 from Patent EP1572962.
JD058800 - Sequence 39824 from Patent EP1572962.
JD505687 - Sequence 486711 from Patent EP1572962.
JD505686 - Sequence 486710 from Patent EP1572962.
JD107470 - Sequence 88494 from Patent EP1572962.
JD212838 - Sequence 193862 from Patent EP1572962.
JD212839 - Sequence 193863 from Patent EP1572962.
JD198219 - Sequence 179243 from Patent EP1572962.
JD198220 - Sequence 179244 from Patent EP1572962.
JD101179 - Sequence 82203 from Patent EP1572962.
JD101180 - Sequence 82204 from Patent EP1572962.
JD426759 - Sequence 407783 from Patent EP1572962.
JD545246 - Sequence 526270 from Patent EP1572962.
JD310511 - Sequence 291535 from Patent EP1572962.
JD238985 - Sequence 220009 from Patent EP1572962.
JD101227 - Sequence 82251 from Patent EP1572962.
JD552350 - Sequence 533374 from Patent EP1572962.
JD507298 - Sequence 488322 from Patent EP1572962.
JD254620 - Sequence 235644 from Patent EP1572962.
JD506008 - Sequence 487032 from Patent EP1572962.
JD349240 - Sequence 330264 from Patent EP1572962.
JD090642 - Sequence 71666 from Patent EP1572962.
JD294780 - Sequence 275804 from Patent EP1572962.
JD231749 - Sequence 212773 from Patent EP1572962.
JD120004 - Sequence 101028 from Patent EP1572962.
JD531218 - Sequence 512242 from Patent EP1572962.
JD538798 - Sequence 519822 from Patent EP1572962.
JD315736 - Sequence 296760 from Patent EP1572962.
JD401109 - Sequence 382133 from Patent EP1572962.
JD475855 - Sequence 456879 from Patent EP1572962.
JD418803 - Sequence 399827 from Patent EP1572962.
JD162628 - Sequence 143652 from Patent EP1572962.
JD066399 - Sequence 47423 from Patent EP1572962.
JD232142 - Sequence 213166 from Patent EP1572962.
JD510498 - Sequence 491522 from Patent EP1572962.
JD151191 - Sequence 132215 from Patent EP1572962.
JD346545 - Sequence 327569 from Patent EP1572962.
JD180455 - Sequence 161479 from Patent EP1572962.
JD263807 - Sequence 244831 from Patent EP1572962.
JD422515 - Sequence 403539 from Patent EP1572962.
JD371400 - Sequence 352424 from Patent EP1572962.
JD463643 - Sequence 444667 from Patent EP1572962.
JD477607 - Sequence 458631 from Patent EP1572962.
JD352830 - Sequence 333854 from Patent EP1572962.
JD191418 - Sequence 172442 from Patent EP1572962.
MP573190 - Sequence 77 from Patent EP3636764.
MP573193 - Sequence 80 from Patent EP3636764.
MP573189 - Sequence 76 from Patent EP3636764.
MP573187 - Sequence 74 from Patent EP3636764.
MP573186 - Sequence 73 from Patent EP3636764.
MP573188 - Sequence 75 from Patent EP3636764.
MP573197 - Sequence 84 from Patent EP3636764.
MP573191 - Sequence 78 from Patent EP3636764.
MP573192 - Sequence 79 from Patent EP3636764.
MP573198 - Sequence 85 from Patent EP3636764.
MP573196 - Sequence 83 from Patent EP3636764.
MP573194 - Sequence 81 from Patent EP3636764.
MP573195 - Sequence 82 from Patent EP3636764.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O00626 (Reactome details) participates in the following event(s):

R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A-152E5.1, A0N0Q6, B2R4W2, CCL22_HUMAN, ENST00000219235.1, ENST00000219235.2, ENST00000219235.3, ENST00000219235.4, MDC, NM_002990, O00626, SCYA22, uc317cwq.1, uc317cwq.2
UCSC ID: ENST00000219235.5_4
RefSeq Accession: NM_002990.5
Protein: O00626 (aka CCL22_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.