Human Gene CELA3A (ENST00000290122.8_4) from GENCODE V47lift37
  Description: chymotrypsin like elastase 3A (from RefSeq NM_005747.5)
Gencode Transcript: ENST00000290122.8_4
Gencode Gene: ENSG00000142789.20_11
Transcript (Including UTRs)
   Position: hg19 chr1:22,328,150-22,339,035 Size: 10,886 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr1:22,328,168-22,338,960 Size: 10,793 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:22,328,150-22,339,035)mRNA (may differ from genome)Protein (270 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CEL3A_HUMAN
DESCRIPTION: RecName: Full=Chymotrypsin-like elastase family member 3A; EC=3.4.21.70; AltName: Full=Elastase IIIA; AltName: Full=Elastase-3A; AltName: Full=Protease E; Flags: Precursor;
FUNCTION: Efficient protease with alanine specificity but only little elastolytic activity.
CATALYTIC ACTIVITY: Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.
SIMILARITY: Belongs to the peptidase S1 family. Elastase subfamily.
SIMILARITY: Contains 1 peptidase S1 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CELA3A
Diseases sorted by gene-association score: holoprosencephaly 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24050.20 RPKM in Pancreas
Total median expression: 24098.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00180.000 Picture PostScript Text
3' UTR -10.8075-0.144 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin
PF13365 - Trypsin-like peptidase domain

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on P09093
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis

Cellular Component:
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  AK308518 - Homo sapiens cDNA, FLJ98559.
AK092382 - Homo sapiens cDNA FLJ35063 fis, clone PANCR1000086, highly similar to ELASTASE IIIB PRECURSOR (EC 3.4.21.70).
AX747509 - Sequence 1034 from Patent EP1308459.
AK308510 - Homo sapiens cDNA, FLJ98551.
D00306 - Homo sapiens mRNA for pancreatic protease E precursor, complete cds.
BC015103 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:22851 IMAGE:3950076), complete cds.
BC005918 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:14514 IMAGE:4295129), complete cds.
BC007028 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:12383 IMAGE:3950453), complete cds.
JD084964 - Sequence 65988 from Patent EP1572962.
AK308514 - Homo sapiens cDNA, FLJ98555.
BC008383 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:12505 IMAGE:3949901), complete cds.
AK225620 - Homo sapiens mRNA for elastase 3A, pancreatic preproprotein variant, clone: PNC07621.
CU678941 - Synthetic construct Homo sapiens gateway clone IMAGE:100016938 5' read ELA3A mRNA.
KJ898164 - Synthetic construct Homo sapiens clone ccsbBroadEn_07558 CELA3A gene, encodes complete protein.
DQ896490 - Synthetic construct Homo sapiens clone IMAGE:100010950; FLH194807.01L; RZPDo839F0470D elastase 3A, pancreatic (ELA3A) gene, encodes complete protein.
KJ906025 - Synthetic construct Homo sapiens clone ccsbBroadEn_15695 CELA3A gene, encodes complete protein.
CU675183 - Synthetic construct Homo sapiens gateway clone IMAGE:100023343 5' read ELA3A mRNA.
KJ898165 - Synthetic construct Homo sapiens clone ccsbBroadEn_07559 CELA3A gene, encodes complete protein.
DQ893182 - Synthetic construct clone IMAGE:100005812; FLH194811.01X; RZPDo839F0480D elastase 3A, pancreatic (ELA3A) gene, encodes complete protein.
E00833 - DNA sequence of human elastase I.
E01101 - DNA sequence of human pancreas elastase IIIA.
JD040731 - Sequence 21755 from Patent EP1572962.
JD275300 - Sequence 256324 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B1AQ53, CEL3A_HUMAN, ELA3, ELA3A, ENST00000290122.1, ENST00000290122.2, ENST00000290122.3, ENST00000290122.4, ENST00000290122.5, ENST00000290122.6, ENST00000290122.7, NM_005747, P09093, Q9BRW4, uc317kts.1, uc317kts.2
UCSC ID: ENST00000290122.8_4
RefSeq Accession: NM_005747.5
Protein: P09093 (aka CEL3A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.