Human Gene CXCR2 (ENST00000318507.7_4) from GENCODE V47lift37
  Description: C-X-C motif chemokine receptor 2, transcript variant 1 (from RefSeq NM_001557.4)
Gencode Transcript: ENST00000318507.7_4
Gencode Gene: ENSG00000180871.8_14
Transcript (Including UTRs)
   Position: hg19 chr2:218,990,751-219,001,974 Size: 11,224 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr2:218,999,525-219,000,607 Size: 1,083 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:218,990,751-219,001,974)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q53PC4_HUMAN
DESCRIPTION: SubName: Full=Interleukin 8 receptor, beta; SubName: Full=Putative uncharacterized protein IL8RB; SubName: Full=cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA; SubName: Full=cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA;
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CXCR2
Diseases sorted by gene-association score: autosomal recessive severe congenital neutropenia due to cxcr2 deficiency* (350), human granulocytic anaplasmosis (16), acute pyelonephritis (8), septicemic plague (7), lipid pneumonia (6), pyelonephritis (5), cervix small cell carcinoma (5), bacteriuria (5), mycetoma (5), pulmonary disease, chronic obstructive (4), melanoma (3), pulmonary fibrosis, idiopathic (1), behcet syndrome (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 173.56 RPKM in Whole Blood
Total median expression: 220.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.70403-0.322 Picture PostScript Text
3' UTR -352.001367-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000174 - Chemokine_CXC/IL8_rcpt
IPR000057 - Chemokine_CXCR2/IL8RB
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q53PC4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019959 interleukin-8 binding

Biological Process:
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0030593 neutrophil chemotaxis
GO:0030901 midbrain development
GO:0033030 negative regulation of neutrophil apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0070098 chemokine-mediated signaling pathway
GO:0072173 metanephric tubule morphogenesis
GO:0090023 positive regulation of neutrophil chemotaxis

Cellular Component:
GO:0005623 cell
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  U11872 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB1, partial cds.
U11873 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB2, partial cds.
LQ882928 - Sequence 77 from Patent WO2018160841.
U11874 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB3, partial cds.
L19593 - Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA, complete cds.
U11875 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB4, partial cds.
BC037961 - Homo sapiens interleukin 8 receptor, beta, mRNA (cDNA clone MGC:46215 IMAGE:5752441), complete cds.
JD372511 - Sequence 353535 from Patent EP1572962.
AK290906 - Homo sapiens cDNA FLJ78215 complete cds, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA.
AK312664 - Homo sapiens cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA.
JD158444 - Sequence 139468 from Patent EP1572962.
JD051664 - Sequence 32688 from Patent EP1572962.
U11876 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB7, partial cds.
M94582 - Human interleuken 8 receptor B mRNA, complete cds.
U11877 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB9, partial cds.
U11878 - Human interleukin-8 receptor type B (IL8RB) mRNA, splice variant IL8RB10, partial cds.
M73969 - Human interleukin-8 receptor type B (IL8RB) mRNA, complete cds.
AB464599 - Synthetic construct DNA, clone: pF1KB9842, Homo sapiens IL8RB gene for interleukin 8 receptor, beta, without stop codon, in Flexi system.
DQ895671 - Synthetic construct Homo sapiens clone IMAGE:100010131; FLH186509.01L; RZPDo839F0461D interleukin 8 receptor, beta (IL8RB) gene, encodes complete protein.
KJ891462 - Synthetic construct Homo sapiens clone ccsbBroadEn_00856 CXCR2 gene, encodes complete protein.
DQ893661 - Synthetic construct clone IMAGE:100006291; FLH186513.01X; RZPDo839F0471D interleukin 8 receptor, beta (IL8RB) gene, encodes complete protein.
E11245 - Human cDNA encoding interleukin 8 receptor type B.
JD126227 - Sequence 107251 from Patent EP1572962.
JD144465 - Sequence 125489 from Patent EP1572962.
JD290434 - Sequence 271458 from Patent EP1572962.
JD493282 - Sequence 474306 from Patent EP1572962.
JD546901 - Sequence 527925 from Patent EP1572962.
JD250678 - Sequence 231702 from Patent EP1572962.
JD289481 - Sequence 270505 from Patent EP1572962.
JD042317 - Sequence 23341 from Patent EP1572962.
JD328162 - Sequence 309186 from Patent EP1572962.
JD159041 - Sequence 140065 from Patent EP1572962.
JD208848 - Sequence 189872 from Patent EP1572962.
JD395785 - Sequence 376809 from Patent EP1572962.
JD144707 - Sequence 125731 from Patent EP1572962.
JD089578 - Sequence 70602 from Patent EP1572962.
JD546178 - Sequence 527202 from Patent EP1572962.
JD221641 - Sequence 202665 from Patent EP1572962.
JD496205 - Sequence 477229 from Patent EP1572962.
JD181004 - Sequence 162028 from Patent EP1572962.
JD194613 - Sequence 175637 from Patent EP1572962.
JD194614 - Sequence 175638 from Patent EP1572962.
JD051335 - Sequence 32359 from Patent EP1572962.
JD217445 - Sequence 198469 from Patent EP1572962.
JD135670 - Sequence 116694 from Patent EP1572962.
JD135669 - Sequence 116693 from Patent EP1572962.
JD080905 - Sequence 61929 from Patent EP1572962.
JD138480 - Sequence 119504 from Patent EP1572962.
JD176571 - Sequence 157595 from Patent EP1572962.
JD066841 - Sequence 47865 from Patent EP1572962.
JD561493 - Sequence 542517 from Patent EP1572962.
JD282110 - Sequence 263134 from Patent EP1572962.
JD230406 - Sequence 211430 from Patent EP1572962.
JD270832 - Sequence 251856 from Patent EP1572962.
JD534728 - Sequence 515752 from Patent EP1572962.
JD507495 - Sequence 488519 from Patent EP1572962.
JD429657 - Sequence 410681 from Patent EP1572962.
JD508073 - Sequence 489097 from Patent EP1572962.
JD204059 - Sequence 185083 from Patent EP1572962.
MP584578 - Sequence 77 from Patent WO2020081767.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000318507.1, ENST00000318507.2, ENST00000318507.3, ENST00000318507.4, ENST00000318507.5, ENST00000318507.6, hCG_16291 , IL8RB , NM_001557, Q53PC4, Q53PC4_HUMAN, uc317qmm.1, uc317qmm.2
UCSC ID: ENST00000318507.7_4
RefSeq Accession: NM_001557.4
Protein: Q53PC4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.