Human Gene DUSP23 (ENST00000368107.2_4) from GENCODE V47lift37
  Description: dual specificity phosphatase 23, transcript variant 1 (from RefSeq NM_001319658.2)
Gencode Transcript: ENST00000368107.2_4
Gencode Gene: ENSG00000158716.9_7
Transcript (Including UTRs)
   Position: hg19 chr1:159,750,752-159,752,333 Size: 1,582 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:159,750,891-159,752,128 Size: 1,238 Coding Exon Count: 2 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:159,750,752-159,752,333)mRNA (may differ from genome)Protein (150 aa)
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-  Comments and Description Text from UniProtKB
  ID: DUS23_HUMAN
DESCRIPTION: RecName: Full=Dual specificity protein phosphatase 23; EC=3.1.3.16; EC=3.1.3.48; AltName: Full=Low molecular mass dual specificity phosphatase 3; Short=LDP-3; AltName: Full=VH1-like phosphatase Z;
FUNCTION: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=1.498 mM for p-nitrophenylphosphate;
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
TISSUE SPECIFICITY: Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CAUTION: Was originally erroneously termed DUSP25.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: DUSP23
Diseases sorted by gene-association score: neuronal intestinal dysplasia (12)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.39 RPKM in Minor Salivary Gland
Total median expression: 1299.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.30139-0.535 Picture PostScript Text
3' UTR -64.00205-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000340 - Dual-sp_phosphatase_cat-dom
IPR026067 - Dual_phosphatase_23
IPR000387 - Tyr/Dual-specificity_Pase
IPR016130 - Tyr_Pase_AS

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase
PF00782 - Dual specificity phosphatase, catalytic domain
PF14566 - Inositol hexakisphosphate

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2IMG - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BVJ7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  KJ894093 - Synthetic construct Homo sapiens clone ccsbBroadEn_03487 DUSP23 gene, encodes complete protein.
KR709837 - Synthetic construct Homo sapiens clone CCSBHm_00006468 DUSP23 (DUSP23) mRNA, encodes complete protein.
HM005372 - Homo sapiens clone HTL-T-59 testicular tissue protein Li 59 mRNA, complete cds.
AK000449 - Homo sapiens cDNA FLJ20442 fis, clone KAT04828.
BC001140 - Homo sapiens dual specificity phosphatase 23, mRNA (cDNA clone MGC:1042 IMAGE:3535406), complete cds.
AB164404 - Homo sapiens LDP-3 mRNA for low-molecular-mass dual-specificity phosphatase 3, complete cds.
JF432846 - Synthetic construct Homo sapiens clone IMAGE:100074167 dual specificity phosphatase 23 (DUSP23) gene, encodes complete protein.
AF086553 - Homo sapiens full length insert cDNA clone ZE12H05.
JD289555 - Sequence 270579 from Patent EP1572962.
JD535756 - Sequence 516780 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DUS23_HUMAN, ENST00000368107.1, LDP3, NM_001319658, Q9BVJ7, Q9NX48, uc318gmc.1, uc318gmc.2, VHZ
UCSC ID: ENST00000368107.2_4
RefSeq Accession: NM_001319658.2
Protein: Q9BVJ7 (aka DUS23_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.