Human Gene EPHA5 (ENST00000613740.5_9) from GENCODE V47lift37
  Description: EPH receptor A5, transcript variant 4 (from RefSeq NM_001281766.3)
Gencode Transcript: ENST00000613740.5_9
Gencode Gene: ENSG00000145242.14_16
Transcript (Including UTRs)
   Position: hg19 chr4:66,185,285-66,536,207 Size: 350,923 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr4:66,189,832-66,535,460 Size: 345,629 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:66,185,285-66,536,207)mRNA (may differ from genome)Protein (1016 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B7ZKW7_HUMAN
DESCRIPTION: SubName: Full=EPHA5 protein;
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SIMILARITY: Contains 1 Eph LBD (Eph ligand-binding) domain.
SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: EPHA5
Diseases sorted by gene-association score: leber congenital amaurosis 17 (12), acrodermatitis chronica atrophicans (12), drug-induced mental disorder (9), drug psychosis (9), lung large cell carcinoma (7), primary bacterial infectious disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -238.90747-0.320 Picture PostScript Text
3' UTR -948.544547-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001090 - Ephrin_rcpt_lig-bd_dom
IPR003961 - Fibronectin_type3
IPR008979 - Galactose-bd-like
IPR013783 - Ig-like_fold
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR021129 - SAM_type1
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR016257 - Tyr_kinase_ephrin_rcpt
IPR001426 - Tyr_kinase_rcpt_V_CS

Pfam Domains:
PF00041 - Fibronectin type III domain
PF00069 - Protein kinase domain
PF00536 - SAM domain (Sterile alpha motif)
PF01404 - Ephrin receptor ligand binding domain
PF07647 - SAM domain (Sterile alpha motif)
PF07714 - Protein tyrosine and serine/threonine kinase
PF14575 - Ephrin type-A receptor 2 transmembrane domain

SCOP Domains:
47769 - SAM/Pointed domain
49363 - Purple acid phosphatase, N-terminal domain
49265 - Fibronectin type III
49785 - Galactose-binding domain-like
56112 - Protein kinase-like (PK-like)
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on B7ZKW7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005003 ephrin receptor activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0048013 ephrin receptor signaling pathway

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BX537946 - Homo sapiens mRNA; cDNA DKFZp686C0686 (from clone DKFZp686C0686); complete cds.
GQ901043 - Homo sapiens clone HEL-T-155 epididymis secretory sperm binding protein mRNA, complete cds.
L36644 - Homo sapiens receptor protein-tyrosine kinase (HEK7) mRNA, 3' end.
BC136257 - Homo sapiens EPH receptor A5, mRNA (cDNA clone MGC:167867 IMAGE:9020244), complete cds.
BC143427 - Homo sapiens EPH receptor A5, mRNA (cDNA clone MGC:176952 IMAGE:9051935), complete cds.
BC136258 - Homo sapiens EPH receptor A5, mRNA (cDNA clone MGC:167868 IMAGE:9020245), complete cds.
X95425 - H.sapiens mRNA for EHK-1 receptor tyrosine kinase.
AM393049 - Synthetic construct Homo sapiens clone IMAGE:100002341 for hypothetical protein (EPHA5 gene).
AM393488 - Synthetic construct Homo sapiens clone IMAGE:100002358 for hypothetical protein (EPHA5 gene).
AB209375 - Homo sapiens mRNA for ephrin receptor EphA5 isoform a variant protein.
AK307826 - Homo sapiens cDNA, FLJ97774.
AB384927 - Synthetic construct DNA, clone: pF1KB4321, Homo sapiens EPHA5 gene for ephrin type-A receptor 5 precursor, complete cds, without stop codon, in Flexi system.
JD433790 - Sequence 414814 from Patent EP1572962.
JD495171 - Sequence 476195 from Patent EP1572962.
JD490635 - Sequence 471659 from Patent EP1572962.
CQ873829 - Sequence 248 from Patent WO2004076622.
DD413666 - Regulation of Mammalian Cells.
JD404466 - Sequence 385490 from Patent EP1572962.
JD560203 - Sequence 541227 from Patent EP1572962.
JD379200 - Sequence 360224 from Patent EP1572962.
JD128191 - Sequence 109215 from Patent EP1572962.
JD520243 - Sequence 501267 from Patent EP1572962.
JD316202 - Sequence 297226 from Patent EP1572962.
JD512199 - Sequence 493223 from Patent EP1572962.
JD140855 - Sequence 121879 from Patent EP1572962.
JD259969 - Sequence 240993 from Patent EP1572962.
JD187513 - Sequence 168537 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZKW7, B7ZKW7_HUMAN, ENST00000613740.1, ENST00000613740.2, ENST00000613740.3, ENST00000613740.4, EPHA5 , NM_001281766, uc327ouu.1, uc327ouu.2
UCSC ID: ENST00000613740.5_9
RefSeq Accession: NM_001281766.3
Protein: B7ZKW7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.