Human Gene FGF10 (ENST00000264664.5_6) from GENCODE V47lift37
  Description: fibroblast growth factor 10 (from RefSeq NM_004465.2)
Gencode Transcript: ENST00000264664.5_6
Gencode Gene: ENSG00000070193.5_9
Transcript (Including UTRs)
   Position: hg19 chr5:44,300,349-44,389,522 Size: 89,174 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr5:44,305,097-44,388,784 Size: 83,688 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:44,300,349-44,389,522)mRNA (may differ from genome)Protein (208 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FGF10_HUMAN
DESCRIPTION: RecName: Full=Fibroblast growth factor 10; Short=FGF-10; AltName: Full=Keratinocyte growth factor 2; Flags: Precursor;
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
SUBCELLULAR LOCATION: Secreted (Potential).
DISEASE: Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
DISEASE: Defects in FGF10 are a cause of lacrimo-auriculo-dento- digital syndrome (LADDS) [MIM:149730]; also known as Levy- Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
SIMILARITY: Belongs to the heparin-binding growth factors family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf10/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FGF10
Diseases sorted by gene-association score: aplasia of lacrimal and salivary glands* (1380), ladd syndrome* (1115), fgf10-related lacrimo-auriculo-dento-digital syndrome* (100), clear cell acanthoma (23), apert syndrome (23), acanthoma (17), pleuropulmonary blastoma (16), mesenteric vascular occlusion (16), craniosynostosis (11), dental caries (9), pfeiffer syndrome (8), microphthalmia, syndromic 9 (8), hypospadias (7), excessive tearing (7), esophageal atresia/tracheoesophageal fistula (7), bronchopulmonary dysplasia (6), hard palate cancer (6), muenke syndrome (6), diaphragm disease (5), gilles de la tourette syndrome (2), tooth agenesis (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.18 RPKM in Cervix - Ectocervix
Total median expression: 75.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -254.00738-0.344 Picture PostScript Text
3' UTR -1087.104748-0.229 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008996 - Cytokine_IL1-like
IPR002209 - GF_heparin-bd
IPR002348 - IL1_HBGF

Pfam Domains:
PF00167 - Fibroblast growth factor

SCOP Domains:
50353 - Cytokine
50405 - Actin-crosslinking proteins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1NUN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O15520
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005111 type 2 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0042056 chemoattractant activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process:
GO:0000132 establishment of mitotic spindle orientation
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001656 metanephros development
GO:0001759 organ induction
GO:0001823 mesonephros development
GO:0001974 blood vessel remodeling
GO:0003338 metanephros morphogenesis
GO:0006935 chemotaxis
GO:0007267 cell-cell signaling
GO:0007368 determination of left/right symmetry
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009880 embryonic pattern specification
GO:0009887 animal organ morphogenesis
GO:0010468 regulation of gene expression
GO:0010469 regulation of receptor activity
GO:0010631 epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014070 response to organic cyclic compound
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030324 lung development
GO:0030538 embryonic genitalia morphogenesis
GO:0030855 epithelial cell differentiation
GO:0030878 thyroid gland development
GO:0030916 otic vesicle formation
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031076 embryonic camera-type eye development
GO:0031532 actin cytoskeleton reorganization
GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032781 positive regulation of ATPase activity
GO:0032808 lacrimal gland development
GO:0032925 regulation of activin receptor signaling pathway
GO:0034394 protein localization to cell surface
GO:0035019 somatic stem cell population maintenance
GO:0035108 limb morphogenesis
GO:0035265 organ growth
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0042472 inner ear morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042693 muscle cell fate commitment
GO:0043410 positive regulation of MAPK cascade
GO:0043616 keratinocyte proliferation
GO:0045596 negative regulation of cell differentiation
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045747 positive regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046854 phosphatidylinositol phosphorylation
GO:0046877 regulation of saliva secretion
GO:0048146 positive regulation of fibroblast proliferation
GO:0048286 lung alveolus development
GO:0048514 blood vessel morphogenesis
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048645 animal organ formation
GO:0048730 epidermis morphogenesis
GO:0048752 semicircular canal morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048807 female genitalia morphogenesis
GO:0048808 male genitalia morphogenesis
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050674 urothelial cell proliferation
GO:0050677 positive regulation of urothelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050872 white fat cell differentiation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:0051549 positive regulation of keratinocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0060019 radial glial cell differentiation
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060436 bronchiole morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060447 bud outgrowth involved in lung branching
GO:0060449 bud elongation involved in lung branching
GO:0060496 mesenchymal-epithelial cell signaling involved in lung development
GO:0060510 Type II pneumocyte differentiation
GO:0060513 prostatic bud formation
GO:0060541 respiratory system development
GO:0060594 mammary gland specification
GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060615 mammary gland bud formation
GO:0060661 submandibular salivary gland formation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060667 branch elongation involved in salivary gland morphogenesis
GO:0060879 semicircular canal fusion
GO:0060915 mesenchymal cell differentiation involved in lung development
GO:0061033 secretion by lung epithelial cell involved in lung growth
GO:0061115 lung proximal/distal axis specification
GO:0070075 tear secretion
GO:0070352 positive regulation of white fat cell proliferation
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070384 Harderian gland development
GO:0071157 negative regulation of cell cycle arrest
GO:0071338 positive regulation of hair follicle cell proliferation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031012 extracellular matrix


-  Descriptions from all associated GenBank mRNAs
  AK023508 - Homo sapiens cDNA FLJ13446 fis, clone PLACE1002968.
BC105021 - Homo sapiens fibroblast growth factor 10, mRNA (cDNA clone MGC:132681 IMAGE:8144024), complete cds.
BC143772 - Homo sapiens cDNA clone IMAGE:9052286.
BC105023 - Homo sapiens fibroblast growth factor 10, mRNA (cDNA clone MGC:132683 IMAGE:8144026), complete cds.
AB002097 - Homo sapiens mRNA for FGF-10, complete cds.
AF411527 - Homo sapiens keratinocyte growth factor 2 (FGF10) mRNA, complete cds.
BC069561 - Homo sapiens fibroblast growth factor 10, mRNA (cDNA clone MGC:96968 IMAGE:7262177), complete cds.
CR541665 - Homo sapiens full open reading frame cDNA clone RZPDo834E0327D for gene FGF10, fibroblast growth factor 10; complete cds, incl. stopcodon.
GQ351295 - Homo sapiens fibroblast growth factor 10 (FGF10) mRNA, complete cds.
U67918 - Human keratinocyte growth factor 2 mRNA, complete cds.
AK315314 - Homo sapiens cDNA, FLJ96346.
HQ258011 - Synthetic construct Homo sapiens clone IMAGE:100072320 fibroblast growth factor 10 (FGF10) gene, encodes complete protein.
KJ891163 - Synthetic construct Homo sapiens clone ccsbBroadEn_00557 FGF10 gene, encodes complete protein.
KR711333 - Synthetic construct Homo sapiens clone CCSBHm_00022931 FGF10 (FGF10) mRNA, encodes complete protein.
KR711334 - Synthetic construct Homo sapiens clone CCSBHm_00022932 FGF10 (FGF10) mRNA, encodes complete protein.
KR711335 - Synthetic construct Homo sapiens clone CCSBHm_00022934 FGF10 (FGF10) mRNA, encodes complete protein.
KR711336 - Synthetic construct Homo sapiens clone CCSBHm_00022935 FGF10 (FGF10) mRNA, encodes complete protein.
AF508782 - Homo sapiens fibroblast growth factor 10 (FGF10) mRNA, partial cds.
CR541688 - Homo sapiens full open reading frame cDNA clone RZPDo834B0928D for gene FGF10, fibroblast growth factor 10; complete cds, without stopcodon.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O15520 (Reactome details) participates in the following event(s):

R-HSA-190245 FGFR1b binds to FGF
R-HSA-2033472 FGFR2c mutants bind an expanded range of ligands
R-HSA-5654511 FGFRL1 dimer binds FGFs
R-HSA-5656070 FGFBPs bind FGFs
R-HSA-190427 Autocatalytic phosphorylation of FGFR1b
R-HSA-2033474 FGFR2b mutants bind an expanded range of ligands
R-HSA-2077421 FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer
R-HSA-2033486 Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
R-HSA-5654167 Activated FGFR1 binds PLCG1
R-HSA-5654569 Activated FGFR1 binds FRS2
R-HSA-5654571 Activated FGFR1 binds FRS3
R-HSA-5654573 Activated FGFR1 binds SHC1
R-HSA-5656064 Activated FGFR1 binds FLRT1,2,3
R-HSA-5654165 p-4Y-PLCG1 dissociates from activated FGFR1
R-HSA-190408 Autocatalytic phosphorylation of FGFR2b
R-HSA-2033488 Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
R-HSA-2077424 Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors
R-HSA-5655339 Activated FGFR2 mutants bind FRS2
R-HSA-5655343 Activated FGFR2 mutants bind PLCG1
R-HSA-5654748 p-4Y-PLCG1 dissociates from activated FGFR2 mutants
R-HSA-5654149 Activated FGFR1 phosphorylates PLCG1
R-HSA-5654560 Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.
R-HSA-5654575 Activated FGFR1 phosphorylates FRS2
R-HSA-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654578 Activated FGFR1 phosphorylates FRS3
R-HSA-5654582 Activated FGFR1 phosphorylates SHC1
R-HSA-5654597 Activated FGFR1:p-SHC1 binds GRB2:SOS1
R-HSA-5654159 Activated FGFR2 binds PLCG1
R-HSA-5654399 Activated FGFR2 binds FRS2
R-HSA-5654404 Activated FGFR2 binds SHC1
R-HSA-5654603 Activated FGFR2 binds FRS3
R-HSA-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-HSA-5655301 Activated FGFR2 mutants phosphorylate PLCG1
R-HSA-5655233 Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1
R-HSA-5655320 Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5655268 Activated FGFR2 mutants phosphorylate FRS2
R-HSA-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654673 p-CBL:GRB2 binds p-FRS2:activated FGFR1
R-HSA-5654584 Activated FGFR1:p-FRS bind to PPTN11
R-HSA-5654586 Activated FGFR1:p-FRS binds GRB2:SOS1
R-HSA-5654147 Activated FGFR2 phosphorylates PLCG1
R-HSA-5654397 Activated FGFR2 phosphorylates FRS2
R-HSA-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-HSA-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-HSA-5654605 Activated FGFR2 phosphorylates FRS3
R-HSA-5654407 Activated FGFR2 phosphorylates SHC1
R-HSA-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-HSA-5655245 Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654672 CBL ubiquitinates FRS2 and FGFR1
R-HSA-5654587 Activated FGFR1:p-FRS phosphorylates PPTN11
R-HSA-5654600 Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-HSA-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-HSA-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-HSA-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-HSA-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-HSA-5655241 Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654392 Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-HSA-5654677 CBL ubiquitinates FRS2 and FGFR2
R-HSA-5654607 Activated FGFR2 phosphorylates PPTN11
R-HSA-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-5655323 Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-HSA-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-HSA-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-HSA-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-190242 FGFR1 ligand binding and activation
R-HSA-190241 FGFR2 ligand binding and activation
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-5654736 Signaling by FGFR1
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654738 Signaling by FGFR2
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-190236 Signaling by FGFR
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654696 Downstream signaling of activated FGFR2
R-HSA-5663202 Diseases of signal transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-109704 PI3K Cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5683057 MAPK family signaling cascades
R-HSA-112399 IRS-mediated signalling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: C7FDY0, ENST00000264664.1, ENST00000264664.2, ENST00000264664.3, ENST00000264664.4, FGF10_HUMAN, NM_004465, O15520, Q6FHR3, Q6FHT6, Q96P59, uc317hue.1, uc317hue.2
UCSC ID: ENST00000264664.5_6
RefSeq Accession: NM_004465.2
Protein: O15520 (aka FGF10_HUMAN or FGFA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.