Human Gene FKBP5 (ENST00000357266.9_6) from GENCODE V47lift37
Description: FKBP prolyl isomerase 5, transcript variant 1 (from RefSeq NM_004117.4)
Gencode Transcript: ENST00000357266.9_6
Gencode Gene: ENSG00000096060.15_8
Transcript (Including UTRs)
Position: hg19 chr6:35,541,367-35,656,692 Size: 115,326 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr6:35,543,612-35,610,601 Size: 66,990 Coding Exon Count: 10
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: FKBP5_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP5; Short=PPIase FKBP5; EC=5.2.1.8; AltName: Full=51 kDa FK506-binding protein; Short=51 kDa FKBP; Short=FKBP-51; AltName: Full=54 kDa progesterone receptor-associated immunophilin; AltName: Full=Androgen-regulated protein 6; AltName: Full=FF1 antigen; AltName: Full=FK506-binding protein 5; Short=FKBP-5; AltName: Full=FKBP54; Short=p54; AltName: Full=HSP90-binding immunophilin; AltName: Full=Rotamase;
FUNCTION: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP.CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).ENZYME REGULATION: Inhibited by FK506 but not cyclosporin.SUBUNIT: Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid.SUBCELLULAR LOCATION: Cytoplasm. Nucleus.TISSUE SPECIFICITY: Widely expressed, enriched in testis compared to other tissues.INDUCTION: By androgen.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Contains 2 PPIase FKBP-type domains.SIMILARITY: Contains 3 TPR repeats.
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D013749
Tetrachlorodibenzodioxin
D003907
Dexamethasone
D013739
Testosterone
C023514
2,6-dinitrotoluene
D019256
Cadmium Chloride
D002737
Chloroprene
D019327
Copper Sulfate
D010269
Paraquat
D010634
Phenobarbital
D014212
Tretinoin
C006780
bisphenol A
C016104
sodium bichromate
C009495
titanium dioxide
C049325
1,2-dithiol-3-thione
D015056
1-Methyl-3-isobutylxanthine
C020365
17-alpha-hydroxy-progesterone caproate
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C029141
2,2,5,7,8-pentamethyl-1-hydroxychroman
D015085
2,4,5-Trichlorophenoxyacetic Acid
C016403
2,4-dinitrotoluene
C028451
3,4,3',4'-tetrachlorobiphenyl
C472791
3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
C009505
4,4'-diaminodiphenylmethane
D015123
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
C547126
AZM551248
D000082
Acetaminophen
D000111
Acetylcysteine
D016573
Agrochemicals
D000393
Air Pollutants
D000452
Aldrin
D001262
Atenolol
D001554
Benzene
D001564
Benzo(a)pyrene
C099555
CD 437
D002117
Calcitriol
D002330
Carmustine
D002746
Chlorpromazine
D002922
Ciguatoxins
D002994
Clofibrate
D003300
Copper
D003375
Coumestrol
D016572
Cyclosporine
D003622
Dapsone
D003993
Dibutyl Phthalate
D004041
Dietary Fats
D004051
Diethylhexyl Phthalate
D004052
Diethylnitrosamine
D013196
Dihydrotestosterone
D004147
Dioxins
D004317
Doxorubicin
D004958
Estradiol
D005472
Fluorouracil
D005576
Forskolin
D019833
Genistein
D006540
Herbicides
D006854
Hydrocortisone
D007545
Isoproterenol
D008070
Lipopolysaccharides
D008344
Maneb
D008727
Methotrexate
D015741
Metribolone
D015735
Mifepristone
C558013
NSC 689534
D010126
Ozone
D010695
Phlorhizin
D011374
Progesterone
D020123
Sirolimus
D016559
Tacrolimus
D013629
Tamoxifen
D013755
Tetradecanoylphorbol Acetate
D013866
Thioguanine
D014028
Tobacco Smoke Pollution
D014635
Valproic Acid
D014752
Vinyl Chloride
D015032
Zinc
C109238
acyline
C006418
adrenocorticotropin zinc
C017037
aurin
D019324
beta-Naphthoflavone
C400082
bortezomib
C011585
ciclopirox
C018021
cobaltous chloride
C017180
decamethrin
C069837
fullerene C60
C408042
fullerol C60(OH)24
C051890
irinotecan
C008261
lead acetate
C008493
methylselenic acid
C016599
mono-(2-ethylhexyl)phthalate
C031721
naphthalene
C028007
nickel monoxide
C041786
palm oil
C016030
pantogab
C023036
perfluorooctanoic acid
C006253
pirinixic acid
C005266
quinomethionate
C059514
resveratrol
C089730
rosiglitazone
C017947
sodium arsenite
C013698
tallow
C061133
tamibarotene
C004648
testosterone enanthate
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR023114 - Elongated_TPR_rpt_dom
IPR023566 - PPIase_FKBP
IPR001179 - PPIase_FKBP_dom
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat
Pfam Domains: PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase
PF00515 - Tetratricopeptide repeat
PF13174 - Tetratricopeptide repeat
PF13176 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
SCOP Domains: 81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
54534 - FKBP-like
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q13451
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LP895559 - Sequence 423 from Patent EP3253886.BC111050 - Homo sapiens FK506 binding protein 5, mRNA (cDNA clone MGC:111006 IMAGE:5723416), complete cds.BX647390 - Homo sapiens mRNA; cDNA DKFZp686G08144 (from clone DKFZp686G08144).BC042605 - Homo sapiens FK506 binding protein 5, mRNA (cDNA clone MGC:34489 IMAGE:4539929), complete cds.AF194172 - Homo sapiens androgen-regulated protein 6 (AIG6) mRNA, complete cds.AK302704 - Homo sapiens cDNA FLJ57237 complete cds, highly similar to FK506-binding protein 5 (EC 5.2.1.8).AK303356 - Homo sapiens cDNA FLJ58213 complete cds, highly similar to FK506-binding protein 5 (EC 5.2.1.8).AK222807 - Homo sapiens mRNA for FK506 binding protein 5 variant, clone: HEP04108.U71321 - Human FK506-binding protein FKBP51 mRNA, complete cds.AK312422 - Homo sapiens cDNA, FLJ92761, Homo sapiens FK506 binding protein 5 (FKBP5), mRNA.AB209893 - Homo sapiens mRNA for FK506 binding protein 5 variant protein.HM245391 - Homo sapiens FKBP5-TMPRSS2 breakpoint junction mRNA sequence.AL122066 - Homo sapiens mRNA; cDNA DKFZp434P171 (from clone DKFZp434P171).JD296757 - Sequence 277781 from Patent EP1572962.JD549114 - Sequence 530138 from Patent EP1572962.JD372056 - Sequence 353080 from Patent EP1572962.JD248424 - Sequence 229448 from Patent EP1572962.LF210765 - JP 2014500723-A/18268: Polycomb-Associated Non-Coding RNAs.JD507846 - Sequence 488870 from Patent EP1572962.JD358973 - Sequence 339997 from Patent EP1572962.JD515769 - Sequence 496793 from Patent EP1572962.JD112632 - Sequence 93656 from Patent EP1572962.JD348457 - Sequence 329481 from Patent EP1572962.JD331353 - Sequence 312377 from Patent EP1572962.JD300582 - Sequence 281606 from Patent EP1572962.JD423515 - Sequence 404539 from Patent EP1572962.JD334039 - Sequence 315063 from Patent EP1572962.JD287058 - Sequence 268082 from Patent EP1572962.U42031 - Human 54 kDa progesterone receptor-associated immunophilin FKBP54 mRNA, partial cds.JD398523 - Sequence 379547 from Patent EP1572962.JD202476 - Sequence 183500 from Patent EP1572962.JD561563 - Sequence 542587 from Patent EP1572962.JD291170 - Sequence 272194 from Patent EP1572962.JD066600 - Sequence 47624 from Patent EP1572962.JD150348 - Sequence 131372 from Patent EP1572962.JD383140 - Sequence 364164 from Patent EP1572962.JD343358 - Sequence 324382 from Patent EP1572962.JD472840 - Sequence 453864 from Patent EP1572962.JD283477 - Sequence 264501 from Patent EP1572962.JD088011 - Sequence 69035 from Patent EP1572962.HW800036 - JP 2014530803-A/97: MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE-ASSOCIATED MEDICAL CONDITIONS.JE972046 - Sequence 97 from Patent WO2015118537.LP883688 - Sequence 97 from Patent EP3208338.LX145720 - JP 2017506228-A/97: MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE-ASSOCIATED MEDICAL CONDITIONS.LX245277 - JP 2017095482-A/97: MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE-ASSOCIATED MEDICAL CONDITIONS.JD372657 - Sequence 353681 from Patent EP1572962.JD340286 - Sequence 321310 from Patent EP1572962.AB463641 - Synthetic construct DNA, clone: pF1KB8354, Homo sapiens FKBP5 gene for FK506 binding protein 5, without stop codon, in Flexi system.AM393744 - Synthetic construct Homo sapiens clone IMAGE:100002460 for hypothetical protein (FKBP5 gene).X97300 - H.sapiens mRNA for Ptg-10 protein.HM245388 - Homo sapiens TMPRSS2-FKBP5 breakpoint junction transcript variant 2 and FKBP5-ERG breakpoint junction transcript variant 2 mRNA sequence.HM245387 - Homo sapiens TMPRSS2-FKBP5 breakpoint junction transcript variant 1 and FKBP5-ERG breakpoint junction transcript variant 1 mRNA sequence.JD029219 - Sequence 10243 from Patent EP1572962.JD019294 - Sequence 318 from Patent EP1572962.JD022616 - Sequence 3640 from Patent EP1572962.JD032266 - Sequence 13290 from Patent EP1572962.MA446342 - JP 2018138019-A/18268: Polycomb-Associated Non-Coding RNAs.MP262593 - Sequence 97 from Patent EP3524679.MB471180 - JP 2019172696-A/97: MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE-ASSOCIATED MEDICAL CONDITIONS.JD452364 - Sequence 433388 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: AIG6, ENST00000357266.1, ENST00000357266.2, ENST00000357266.3, ENST00000357266.4, ENST00000357266.5, ENST00000357266.6, ENST00000357266.7, ENST00000357266.8, F5H7R1, FKBP51 , FKBP5_HUMAN, NM_004117, Q13451, Q59EB8, Q5TGM6, uc317zyt.1, uc317zyt.2UCSC ID: ENST00000357266.9_6RefSeq Accession: NM_004117.4
Protein: Q13451
(aka FKBP5_HUMAN or FKB5_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.