Human Gene FOSB (ENST00000353609.8_4) from GENCODE V47lift37
  Description: FosB proto-oncogene, AP-1 transcription factor subunit, transcript variant 1 (from RefSeq NM_006732.3)
Gencode Transcript: ENST00000353609.8_4
Gencode Gene: ENSG00000125740.15_9
Transcript (Including UTRs)
   Position: hg19 chr19:45,971,254-45,978,437 Size: 7,184 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr19:45,971,845-45,976,270 Size: 4,426 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:45,971,254-45,978,437)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FOSB_HUMAN
DESCRIPTION: RecName: Full=Protein fosB; AltName: Full=G0/G1 switch regulatory protein 3;
FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity.
SUBUNIT: Heterodimer (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the bZIP family. Fos subfamily.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fosb/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FOSB
Diseases sorted by gene-association score: short-rib thoracic dysplasia 1 with or without polydactyly (3), short-rib thoracic dysplasia 2 with or without polydactyly (3), proliferative fasciitis (1), vertebral artery occlusion (1), subdural empyema (1), basilar artery occlusion (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 79.20 RPKM in Fallopian Tube
Total median expression: 316.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -218.40591-0.370 Picture PostScript Text
3' UTR -812.002167-0.375 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR000837 - Leuzip_Fos

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on P53539
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007565 female pregnancy
GO:0009612 response to mechanical stimulus
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF207544 - JP 2014500723-A/15047: Polycomb-Associated Non-Coding RNAs.
EU178109 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 1 (FOSB) mRNA, complete cds, alternatively spliced.
EU178110 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 2 (FOSB) mRNA, complete cds, alternatively spliced.
EU178111 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 3 (FOSB) mRNA, complete cds, alternatively spliced.
EU178112 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 4 (FOSB) mRNA, complete cds, alternatively spliced.
EU178113 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 5 (FOSB) mRNA, complete cds, alternatively spliced.
EU178114 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 6 (FOSB) mRNA, complete cds, alternatively spliced.
EU178115 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 7 (FOSB) mRNA, complete cds, alternatively spliced.
EU178116 - Homo sapiens FBJ murine osteosarcoma viral oncogene-like B variant 8 (FOSB) mRNA, complete cds, alternatively spliced.
L49169 - Human G0S3 mRNA, complete cds.
AK097324 - Homo sapiens cDNA FLJ40005 fis, clone STOMA2004668, weakly similar to FOSB PROTEIN.
AK225070 - Homo sapiens mRNA for FBJ murine osteosarcoma viral oncogene homolog B variant, clone: adSU02363.
LF213738 - JP 2014500723-A/21241: Polycomb-Associated Non-Coding RNAs.
BC051767 - Homo sapiens cDNA clone IMAGE:5757194, partial cds.
BC036724 - Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B, mRNA (cDNA clone MGC:39968 IMAGE:5212854), complete cds.
BC063042 - Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B, mRNA (cDNA clone IMAGE:5745635), partial cds.
JD382736 - Sequence 363760 from Patent EP1572962.
JD350548 - Sequence 331572 from Patent EP1572962.
JD358694 - Sequence 339718 from Patent EP1572962.
JD185114 - Sequence 166138 from Patent EP1572962.
JD155623 - Sequence 136647 from Patent EP1572962.
AK292720 - Homo sapiens cDNA FLJ76347 complete cds, highly similar to Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B (FOSB), mRNA.
JD200880 - Sequence 181904 from Patent EP1572962.
JD131742 - Sequence 112766 from Patent EP1572962.
JD108975 - Sequence 89999 from Patent EP1572962.
JD210307 - Sequence 191331 from Patent EP1572962.
CR542101 - Homo sapiens full open reading frame cDNA clone RZPDo834G0237D for gene FOSB, FBJ murine osteosarcoma viral oncogene homolog B; complete cds, without stopcodon.
AB463627 - Synthetic construct DNA, clone: pF1KB7669, Homo sapiens FOSB gene for FBJ murine osteosarcoma viral oncogene homolog B, without stop codon, in Flexi system.
EU832190 - Synthetic construct Homo sapiens clone HAIB:100067219; DKFZo004A1026 FBJ murine osteosarcoma viral oncogene homolog B protein (FOSB) gene, encodes complete protein.
EU832097 - Synthetic construct Homo sapiens clone HAIB:100067126; DKFZo008A1025 FBJ murine osteosarcoma viral oncogene homolog B protein (FOSB) gene, encodes complete protein.
BX538117 - Homo sapiens mRNA; cDNA DKFZp686C0818 (from clone DKFZp686C0818).
BC040197 - Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B, mRNA (cDNA clone MGC:42291 IMAGE:4816584), complete cds.
LF366970 - JP 2014500723-A/174473: Polycomb-Associated Non-Coding RNAs.
BC127825 - Homo sapiens FBJ murine osteosarcoma viral oncogene homolog B, mRNA (cDNA clone IMAGE:40133386), partial cds.
LF366969 - JP 2014500723-A/174472: Polycomb-Associated Non-Coding RNAs.
JA785044 - Sequence 6 from Patent WO2012069613.
JD325317 - Sequence 306341 from Patent EP1572962.
JD097071 - Sequence 78095 from Patent EP1572962.
JD359959 - Sequence 340983 from Patent EP1572962.
JD052900 - Sequence 33924 from Patent EP1572962.
JD330433 - Sequence 311457 from Patent EP1572962.
JD175092 - Sequence 156116 from Patent EP1572962.
JD178356 - Sequence 159380 from Patent EP1572962.
JD340073 - Sequence 321097 from Patent EP1572962.
JD340041 - Sequence 321065 from Patent EP1572962.
JD340047 - Sequence 321071 from Patent EP1572962.
AF432216 - Homo sapiens CLL-associated antigen KW-3 mRNA, 3' untranslated region.
JD060132 - Sequence 41156 from Patent EP1572962.
JD317950 - Sequence 298974 from Patent EP1572962.
JD521826 - Sequence 502850 from Patent EP1572962.
JD501615 - Sequence 482639 from Patent EP1572962.
JD338519 - Sequence 319543 from Patent EP1572962.
JD142988 - Sequence 124012 from Patent EP1572962.
JD453891 - Sequence 434915 from Patent EP1572962.
JD173629 - Sequence 154653 from Patent EP1572962.
JD218939 - Sequence 199963 from Patent EP1572962.
JD297666 - Sequence 278690 from Patent EP1572962.
JD053310 - Sequence 34334 from Patent EP1572962.
JD279326 - Sequence 260350 from Patent EP1572962.
JD402563 - Sequence 383587 from Patent EP1572962.
JD558106 - Sequence 539130 from Patent EP1572962.
JD547839 - Sequence 528863 from Patent EP1572962.
JD366890 - Sequence 347914 from Patent EP1572962.
JD268557 - Sequence 249581 from Patent EP1572962.
JD184354 - Sequence 165378 from Patent EP1572962.
JD188697 - Sequence 169721 from Patent EP1572962.
JD363668 - Sequence 344692 from Patent EP1572962.
JD525200 - Sequence 506224 from Patent EP1572962.
JD054572 - Sequence 35596 from Patent EP1572962.
LF366968 - JP 2014500723-A/174471: Polycomb-Associated Non-Coding RNAs.
JD389880 - Sequence 370904 from Patent EP1572962.
JD399920 - Sequence 380944 from Patent EP1572962.
JD352663 - Sequence 333687 from Patent EP1572962.
JD058286 - Sequence 39310 from Patent EP1572962.
JD120031 - Sequence 101055 from Patent EP1572962.
JD539009 - Sequence 520033 from Patent EP1572962.
JD159753 - Sequence 140777 from Patent EP1572962.
JD093204 - Sequence 74228 from Patent EP1572962.
JD527821 - Sequence 508845 from Patent EP1572962.
JD260234 - Sequence 241258 from Patent EP1572962.
JD269345 - Sequence 250369 from Patent EP1572962.
JD567091 - Sequence 548115 from Patent EP1572962.
D16366 - Homo sapiens cDNA, clone:lg1017.
JD150961 - Sequence 131985 from Patent EP1572962.
JD476380 - Sequence 457404 from Patent EP1572962.
JD290693 - Sequence 271717 from Patent EP1572962.
MA602547 - JP 2018138019-A/174473: Polycomb-Associated Non-Coding RNAs.
MA602546 - JP 2018138019-A/174472: Polycomb-Associated Non-Coding RNAs.
MA602545 - JP 2018138019-A/174471: Polycomb-Associated Non-Coding RNAs.
MA443121 - JP 2018138019-A/15047: Polycomb-Associated Non-Coding RNAs.
MA449315 - JP 2018138019-A/21241: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_fosbPathway - FOSB gene expression and drug abuse

Reactome (by CSHL, EBI, and GO)

Protein P53539 (Reactome details) participates in the following event(s):

R-HSA-9011997 ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A8K9K5, A8VJE1, A8VJE6, A8VJF0, A8VJF3, A8VJF7, A8VJG1, A8VJG5, A8VJG9, E7EPR6, E9PHJ3, ENST00000353609.1, ENST00000353609.2, ENST00000353609.3, ENST00000353609.4, ENST00000353609.5, ENST00000353609.6, ENST00000353609.7, FOSB_HUMAN, G0S3, K7EKC1, K7EMJ6, NM_006732, P53539, Q49AD7, uc317yki.1, uc317yki.2
UCSC ID: ENST00000353609.8_4
RefSeq Accession: NM_006732.3
Protein: P53539 (aka FOSB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.