ID:HNRPF_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein F; Short=hnRNP F; AltName: Full=Nucleolin-like protein mcs94-1; Contains: RecName: Full=Heterogeneous nuclear ribonucleoprotein F, N-terminally processed; FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. SUBUNIT: Identified in the spliceosome C complex. Interacts with EIF2C1, EIF2C2, TBP and TXNL4/DIM1. SUBCELLULAR LOCATION: Nucleus, nucleoplasm. TISSUE SPECIFICITY: Expressed ubiquitously. DOMAIN: The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Sumoylated. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P52597
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ896994 - Synthetic construct Homo sapiens clone ccsbBroadEn_06388 HNRNPF gene, encodes complete protein. KJ896995 - Synthetic construct Homo sapiens clone ccsbBroadEn_06389 HNRNPF gene, encodes complete protein. KJ905782 - Synthetic construct Homo sapiens clone ccsbBroadEn_15452 HNRNPF gene, encodes complete protein. AK001364 - Homo sapiens cDNA FLJ10502 fis, clone NT2RP2000414, highly similar to Heterogeneous nuclear ribonucleoprotein F. BC001432 - Homo sapiens heterogeneous nuclear ribonucleoprotein F, mRNA (cDNA clone MGC:2197 IMAGE:3138435), complete cds. BC016736 - Homo sapiens heterogeneous nuclear ribonucleoprotein F, mRNA (cDNA clone MGC:24536 IMAGE:4104978), complete cds. AB062287 - Homo sapiens OK/SW-cl.23 mRNA for heterogeneous nuclear ribonucleoprotein F, complete cds. BC106008 - Homo sapiens heterogeneous nuclear ribonucleoprotein F, mRNA (cDNA clone MGC:110997 IMAGE:6156823), complete cds. BC015580 - Homo sapiens heterogeneous nuclear ribonucleoprotein F, mRNA (cDNA clone MGC:23274 IMAGE:4636807), complete cds. BC004254 - Homo sapiens heterogeneous nuclear ribonucleoprotein F, mRNA (cDNA clone MGC:10565 IMAGE:3633625), complete cds. L28010 - Homo sapiens HnRNP F protein mRNA, complete cds. JD113561 - Sequence 94585 from Patent EP1572962. JD338047 - Sequence 319071 from Patent EP1572962. AK296696 - Homo sapiens cDNA FLJ57121 complete cds, highly similar to Heterogeneous nuclear ribonucleoprotein F. JD372357 - Sequence 353381 from Patent EP1572962. JD315778 - Sequence 296802 from Patent EP1572962. JD301468 - Sequence 282492 from Patent EP1572962. JD564902 - Sequence 545926 from Patent EP1572962. EU176350 - Synthetic construct Homo sapiens clone IMAGE:100006435; FLH183827.01X; RZPDo839B10251D heterogeneous nuclear ribonucleoprotein F (HNRPF) gene, encodes complete protein. DQ895381 - Synthetic construct Homo sapiens clone IMAGE:100009841; FLH183820.01L; RZPDo839G12141D heterogeneous nuclear ribonucleoprotein F (HNRPF) gene, encodes complete protein. AB384896 - Synthetic construct DNA, clone: pF1KB4092, Homo sapiens HNRPF gene for heterogeneous nuclear ribonucleoprotein F, complete cds, without stop codon, in Flexi system. CU674702 - Synthetic construct Homo sapiens gateway clone IMAGE:100023469 5' read HNRPF mRNA. CU677699 - Synthetic construct Homo sapiens gateway clone IMAGE:100017646 5' read HNRPF mRNA. CU678642 - Synthetic construct Homo sapiens gateway clone IMAGE:100019293 5' read HNRPF mRNA. DQ595699 - Homo sapiens piRNA piR-61811, complete sequence. JD392414 - Sequence 373438 from Patent EP1572962. JD055670 - Sequence 36694 from Patent EP1572962. LF207357 - JP 2014500723-A/14860: Polycomb-Associated Non-Coding RNAs. LF365345 - JP 2014500723-A/172848: Polycomb-Associated Non-Coding RNAs. LF207356 - JP 2014500723-A/14859: Polycomb-Associated Non-Coding RNAs. LF365338 - JP 2014500723-A/172841: Polycomb-Associated Non-Coding RNAs. MA600922 - JP 2018138019-A/172848: Polycomb-Associated Non-Coding RNAs. MA600915 - JP 2018138019-A/172841: Polycomb-Associated Non-Coding RNAs. MA442934 - JP 2018138019-A/14860: Polycomb-Associated Non-Coding RNAs. MA442933 - JP 2018138019-A/14859: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P52597 (Reactome details) participates in the following event(s):
R-HSA-72103 Formation of pre-mRNPs R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-6803527 ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-6803529 FGFR2 alternative splicing R-HSA-8953854 Metabolism of RNA R-HSA-72172 mRNA Splicing R-HSA-9020591 Interleukin-12 signaling R-HSA-5654738 Signaling by FGFR2 R-HSA-447115 Interleukin-12 family signaling R-HSA-190236 Signaling by FGFR R-HSA-449147 Signaling by Interleukins R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-162582 Signal Transduction R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
