ID:HS90A_HUMAN DESCRIPTION: RecName: Full=Heat shock protein HSP 90-alpha; AltName: Full=Heat shock 86 kDa; Short=HSP 86; Short=HSP86; AltName: Full=Renal carcinoma antigen NY-REN-38; FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. SUBUNIT: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. INTERACTION: Self; NbExp=4; IntAct=EBI-296047, EBI-296047; O95433:AHSA1; NbExp=4; IntAct=EBI-296047, EBI-448610; Q96G23:CERS2; NbExp=2; IntAct=EBI-296047, EBI-1057080; Q9UHD1:CHORDC1; NbExp=8; IntAct=EBI-296047, EBI-2550959; P05412:JUN; NbExp=2; IntAct=EBI-296047, EBI-852823; P53041:PPP5C; NbExp=8; IntAct=EBI-296047, EBI-716663; Q15185:PTGES3; NbExp=5; IntAct=EBI-296047, EBI-1049387; P61247:RPS3A; NbExp=2; IntAct=EBI-296047, EBI-352378; Q9UNE7:STUB1; NbExp=9; IntAct=EBI-296047, EBI-357085; SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. DOMAIN: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1. PTM: ISGylated. PTM: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1. SIMILARITY: Belongs to the heat shock protein 90 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07900
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0001934 positive regulation of protein phosphorylation GO:0006457 protein folding GO:0006839 mitochondrial transport GO:0006898 receptor-mediated endocytosis GO:0006950 response to stress GO:0006986 response to unfolded protein GO:0007004 telomere maintenance via telomerase GO:0007165 signal transduction GO:0009408 response to heat GO:0009409 response to cold GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0018108 peptidyl-tyrosine phosphorylation GO:0019221 cytokine-mediated signaling pathway GO:0021955 central nervous system neuron axonogenesis GO:0030010 establishment of cell polarity GO:0031396 regulation of protein ubiquitination GO:0032273 positive regulation of protein polymerization GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038128 ERBB2 signaling pathway GO:0042026 protein refolding GO:0043254 regulation of protein complex assembly GO:0043312 neutrophil degranulation GO:0043335 protein unfolding GO:0045040 protein import into mitochondrial outer membrane GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0046677 response to antibiotic GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048675 axon extension GO:0050821 protein stabilization GO:0050999 regulation of nitric-oxide synthase activity GO:0051131 chaperone-mediated protein complex assembly GO:0051186 cofactor metabolic process GO:0051897 positive regulation of protein kinase B signaling GO:0051973 positive regulation of telomerase activity GO:0061684 chaperone-mediated autophagy GO:0097711 ciliary basal body docking GO:1900034 regulation of cellular response to heat GO:1902949 positive regulation of tau-protein kinase activity GO:1903364 positive regulation of cellular protein catabolic process GO:1903827 regulation of cellular protein localization GO:1905323 telomerase holoenzyme complex assembly
GQ149083 - Homo sapiens epididymis luminal secretory protein 52 (EL52) mRNA, complete cds. AJ890083 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 4 (HSPCA gene). BC007989 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3030617), partial cds. BC000987 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3446372), partial cds. BC023006 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:4404328), partial cds. BC017233 - Homo sapiens cDNA clone IMAGE:4299683, containing frame-shift errors. AK129557 - Homo sapiens cDNA FLJ26046 fis, clone PRS02194, highly similar to Heat shock protein HSP 90-alpha (HSP 86). AJ890082 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 2 (HSPCA gene). AK056446 - Homo sapiens cDNA FLJ31884 fis, clone NT2RP7002906, highly similar to Homo sapiens heat shock 90 kDa protein 1, alpha (HSPCA), transcript variant 1, mRNA. D87666 - Homo sapiens heart mRNA for heat shock protein 90, partial cds. AF028832 - Homo sapiens Hsp89-alpha-delta-N mRNA, complete cds. X15183 - Human mRNA for 90-kDa heat-shock protein. BC121062 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone MGC:149801 IMAGE:40118488), complete cds. GQ472230 - Homo sapiens epididymis secretory sperm binding protein Li 65p (HEL-S-65p) mRNA, complete cds. AK291607 - Homo sapiens cDNA FLJ75475 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA. AK300126 - Homo sapiens cDNA FLJ57431 complete cds, highly similar to Heat shock protein HSP 90-alpha. AK291115 - Homo sapiens cDNA FLJ78691 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA. KJ905786 - Synthetic construct Homo sapiens clone ccsbBroadEn_15456 HSP90AA1 gene, encodes complete protein. KJ897018 - Synthetic construct Homo sapiens clone ccsbBroadEn_06412 HSP90AA1 gene, encodes complete protein. KJ897019 - Synthetic construct Homo sapiens clone ccsbBroadEn_06413 HSP90AA1 gene, encodes complete protein. AB590828 - Synthetic construct DNA, clone: pFN21AB8480, Homo sapiens HSP90AA1 gene for heat shock protein 90kDa alpha (cytosolic), class A member 1, without stop codon, in Flexi system. JD366986 - Sequence 348010 from Patent EP1572962. JD337418 - Sequence 318442 from Patent EP1572962. JD052837 - Sequence 33861 from Patent EP1572962. BX247955 - human full-length cDNA clone CS0CAP007YF18 of Thymus of Homo sapiens (human). BC108695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:6527590), partial cds. DQ580653 - Homo sapiens piRNA piR-48765, complete sequence. AK310595 - Homo sapiens cDNA, FLJ17637. X07270 - Human mRNA for heat shock protein hsp86. BC001695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3050343). BX248761 - human full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens (human).
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_no1Pathway - Actions of Nitric Oxide in the Heart h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system h_aktPathway - AKT Signaling Pathway h_gcrPathway - Corticosteroids and cardioprotection h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality h_acrPathway - Ahr Signal Transduction Pathway h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
Reactome (by CSHL, EBI, and GO)
Protein P07900 (Reactome details) participates in the following event(s):
R-HSA-202129 HSP90 binds eNOS:Caveolin-1:CaM complex R-HSA-5218643 HSP90AA1 binds p-6Y-VEGFR2 R-HSA-1497784 The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle R-HSA-202111 AKT1 phosphorylates eNOS R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-1218824 HSP90 is inactivated by binding to benzaquinoid ansamycins R-HSA-1218833 Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 R-HSA-1247999 EGFRvIII mutant binds chaperone proteins HSP90 and CDC37. R-HSA-1963589 ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 R-HSA-1497796 BH2 binding can lead to eNOS uncoupling R-HSA-5218826 Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 R-HSA-5218838 PXN binds p-6Y,S732-PTK2 R-HSA-5218855 BCAR1 binds p-7Y-PTK2 R-HSA-5218851 p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407 R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-419645 Dimerization of LIMK1 by Hsp90 R-HSA-202137 AKT1 binds eNOS complex via HSP90 R-HSA-202144 Caveolin-1 dissociates from eNOS:CaM:HSP90 complex R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins R-HSA-6798748 Exocytosis of secretory granule lumen proteins R-HSA-2197645 SCARF1 (SREC-I) binds ligands R-HSA-8939203 HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-1918092 CHIP (STUB1) mediates ubiquitination of ERBB2 R-HSA-1918095 CUL5 mediates ubiquitination of ERBB2 R-HSA-1248002 Ligand-independent dimerization of EGFRvIII mutant R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein R-HSA-8852362 GTSE1 binds CDKN1A R-HSA-3371586 Dissociation of cytosolic HSF1:HSP90 complex R-HSA-5324632 Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates R-HSA-1497810 Uncoupled eNOS favours the formation of superoxide R-HSA-5218809 PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 R-HSA-5218828 PTK2/SRC-1 phosphorylates BCAR1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-5082409 Dissociation of HSF1:HSP90 complex in the nucleus R-HSA-202127 eNOS synthesizes NO R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-1220613 EGF-induced dimerization of ligand-responsive EGFR mutants R-HSA-1220612 Binding of EGF to ligand-responsive EGFR mutants R-HSA-1220614 Spontaneous dimerization of ligand-responsive EGFR mutants R-HSA-1248655 Trans-autophosphorylation of EGFRvIII mutant dimers R-HSA-5637764 Binding of GRB2:GAB1:PIK3R1 complex to p-EGFRvIII mutant R-HSA-5637766 Binding of SHC1 to p-5Y-EGFRvIII R-HSA-5637770 Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII R-HSA-5637792 PLC-gamma 1 binds to p-EGFRvIII mutant R-HSA-5637800 Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant R-HSA-5618107 ATP binding to HSP90 triggers conformation change R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex R-HSA-5218822 CRK binds BCAR1 and or PXN R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5324617 HSP90:FKBP4:PTGES3 binds HSF1 trimer R-HSA-1220611 Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors R-HSA-1220610 Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants R-HSA-5637765 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and p-EGFRvIII R-HSA-5637795 Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant R-HSA-5637796 Phosphorylation of SHC1 by p-5Y-EGFRvIII R-HSA-5637798 Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein R-HSA-5218811 DOCK180:ELMO binds CRK R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-8939204 ESTG binds the ESR:chaperone complex R-HSA-1169421 Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers R-HSA-5637806 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) R-HSA-1225947 Binding of SHC1 to p-6Y-EGFR mutants R-HSA-1225949 Binding of CBL to ligand-responsive p-6Y-EGFR mutants R-HSA-1225950 Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants R-HSA-1226016 Binding of GRB2:GAB1:PIK3R1 complex to ligand-responsive p-6Y-EGFR mutants R-HSA-1247841 PLCG1 binds to ligand-responsive p-6Y-EGFR mutants R-HSA-1247842 Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants R-HSA-5218839 DOCK180:ELMO exchanges GTP for GDP, activating RAC1 R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-5637801 Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII R-HSA-5637808 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) R-HSA-1225961 Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex R-HSA-1225952 Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants R-HSA-1225960 Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants R-HSA-1226012 Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and ligand-responsive p-6Y-EGFR mutants R-HSA-1247844 Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants R-HSA-1225951 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) R-HSA-1225957 SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) R-HSA-1226014 Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants R-HSA-203615 eNOS activation R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization�from the centrosome R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-1227986 Signaling by ERBB2 R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-399954 Sema3A PAK dependent Axon repulsion R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-203765 eNOS activation and regulation R-HSA-194138 Signaling by VEGF R-HSA-6798695 Neutrophil degranulation R-HSA-3000484 Scavenging by Class F Receptors R-HSA-8939211 ESR-mediated signaling R-HSA-3371571 HSF1-dependent transactivation R-HSA-8978934 Metabolism of cofactors R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-8863795 Downregulation of ERBB2 signaling R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-3371511 HSF1 activation R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-5617833 Cilium Assembly R-HSA-373755 Semaphorin interactions R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-449147 Signaling by Interleukins R-HSA-202131 Metabolism of nitric oxide R-HSA-168249 Innate Immune System R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-9018519 Estrogen-dependent gene expression R-HSA-9006931 Signaling by Nuclear Receptors R-HSA-3371556 Cellular response to heat stress R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-2262752 Cellular responses to stress R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-422475 Axon guidance R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1430728 Metabolism R-HSA-168256 Immune System R-HSA-5653656 Vesicle-mediated transport R-HSA-3371568 Attenuation phase R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-8953897 Cellular responses to external stimuli R-HSA-5663202 Diseases of signal transduction R-HSA-1266738 Developmental Biology R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1643685 Disease R-HSA-1640170 Cell Cycle
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
