ID:5HT2A_HUMAN DESCRIPTION: RecName: Full=5-hydroxytryptamine receptor 2A; Short=5-HT-2; Short=5-HT-2A; AltName: Full=Serotonin receptor 2A; FUNCTION: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. SUBUNIT: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the postsynaptic thickening of axo-dendritic synapses (By similarity). DOMAIN: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HTR2A";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P28223
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001659 temperature homeostasis GO:0006874 cellular calcium ion homeostasis GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0007210 serotonin receptor signaling pathway GO:0007268 chemical synaptic transmission GO:0007568 aging GO:0007610 behavior GO:0007613 memory GO:0008219 cell death GO:0008284 positive regulation of cell proliferation GO:0010513 positive regulation of phosphatidylinositol biosynthetic process GO:0014059 regulation of dopamine secretion GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014824 artery smooth muscle contraction GO:0014832 urinary bladder smooth muscle contraction GO:0016032 viral process GO:0019233 sensory perception of pain GO:0030431 sleep GO:0033674 positive regulation of kinase activity GO:0042493 response to drug GO:0043267 negative regulation of potassium ion transport GO:0043406 positive regulation of MAP kinase activity GO:0044380 protein localization to cytoskeleton GO:0045600 positive regulation of fat cell differentiation GO:0045821 positive regulation of glycolytic process GO:0045907 positive regulation of vasoconstriction GO:0046718 viral entry into host cell GO:0048148 behavioral response to cocaine GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0050966 detection of mechanical stimulus involved in sensory perception of pain GO:0051209 release of sequestered calcium ion into cytosol GO:0051967 negative regulation of synaptic transmission, glutamatergic GO:0070374 positive regulation of ERK1 and ERK2 cascade
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
