Human Gene IL13 (ENST00000304506.7_5) from GENCODE V47lift37
  Description: interleukin 13, transcript variant 1 (from RefSeq NM_002188.3)
Gencode Transcript: ENST00000304506.7_5
Gencode Gene: ENSG00000169194.10_9
Transcript (Including UTRs)
   Position: hg19 chr5:131,993,865-131,996,802 Size: 2,938 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr5:131,993,879-131,995,974 Size: 2,096 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:131,993,865-131,996,802)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: IL13_HUMAN
DESCRIPTION: RecName: Full=Interleukin-13; Short=IL-13; Flags: Precursor;
FUNCTION: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
SUBUNIT: Interacts with IL13RA2.
INTERACTION: P78552:IL13RA1; NbExp=4; IntAct=EBI-1647828, EBI-1391535;
SUBCELLULAR LOCATION: Secreted.
DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
SIMILARITY: Belongs to the IL-4/IL-13 family.
CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.
SEQUENCE CAUTION: Sequence=AAA36107.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-13 entry; URL="http://en.wikipedia.org/wiki/Interleukin_13";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il13/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IL13
Diseases sorted by gene-association score: asthma* (649), allergic rhinitis* (618), asthma susceptibility, il13-related* (100), rhinitis (52), allergic asthma (38), lipoid nephrosis (27), latex allergy (25), intestinal schistosomiasis (22), keratoconjunctivitis (21), adiposis dolorosa (18), cytokine deficiency (17), peanut allergy (17), schistosomiasis (15), vernal keratoconjunctivitis (15), food allergy (15), allergic conjunctivitis (15), trichuriasis (15), parasitic helminthiasis infectious disease (14), allergic hypersensitivity disease (14), pulmonary eosinophilia (14), atopy (13), paranasal sinus disease (13), beta-lactam allergy (13), nonspecific interstitial pneumonia (13), angioimmunoblastic lymphadenopathy with dysproteinemia (13), penicillin allergy (13), esophagitis (13), actinic prurigo (12), mercury poisoning (12), dermatitis (12), cutaneous leishmaniasis (11), angiostrongyliasis (11), atopic dermatitis (10), inflammatory bowel disease (10), ascaridiasis (10), eosinophilic meningitis (10), bronchiolitis (10), eosinophilic pneumonia (10), idiopathic interstitial pneumonia (10), african tick-bite fever (10), respiratory system disease (10), conjunctivitis (10), paragonimiasis (9), bronchial disease (9), respiratory syncytial virus infectious disease (9), tetanus (8), chronic conjunctivitis (8), pollen allergy (8), stevens-johnson syndrome/toxic epidermal necrolysis (8), diphtheria (7), eosinophilic gastritis (7), apple allergy (7), strongyloidiasis (7), hypereosinophilic syndrome (7), esophagitis, eosinophilic, 1 (7), leishmaniasis (7), onchocerciasis (7), nasal cavity disease (7), leukocyte disease (6), upper respiratory tract disease (6), nose disease (6), psoriatic arthritis (6), mast cell disease (6), urinary schistosomiasis (6), radiculopathy (5), night blindness, congenital stationary , 1a, x-linked (5), inflammatory bowel disease 4 (5), nut allergy (5), conjunctival disease (5), esophageal disease (5), enterobiasis (5), radiation cystitis (5), chronic tic disorder (5), autoinflammation, lipodystrophy, and dermatosis syndrome (4), malignant glioma (4), common cold (4), pulmonary fibrosis, idiopathic (4), pulmonary fibrosis (4), localized osteosarcoma (4), pneumonia (4), lung disease (3), malaria (2), eye disease (2), hypersensitivity reaction disease (1), immune system disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.87 RPKM in Testis
Total median expression: 31.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -306.40828-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009079 - 4_helix_cytokine-like_core
IPR012351 - 4_helix_cytokine_core
IPR020470 - Interleukin-13
IPR018096 - Interleukin-4/-13_CS
IPR001325 - Interleukin-4/13

Pfam Domains:
PF03487 - Interleukin-13

SCOP Domains:
47266 - 4-helical cytokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GA3 - NMR 1IJZ - NMR 1IK0 - NMR 1J9U - Model 3BPO - X-ray MuPIT 3G6D - X-ray 3ITR - Model 3ITS - Model 3L5W - X-ray 3L5X - X-ray 3L5Y - X-ray 3LB6 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P35225
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005144 interleukin-13 receptor binding
GO:0005515 protein binding

Biological Process:
GO:0001774 microglial cell activation
GO:0002639 positive regulation of immunoglobulin production
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0009612 response to mechanical stimulus
GO:0010155 regulation of proton transport
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0030890 positive regulation of B cell proliferation
GO:0032496 response to lipopolysaccharide
GO:0032723 positive regulation of connective tissue growth factor production
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035094 response to nicotine
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043032 positive regulation of macrophage activation
GO:0043270 positive regulation of ion transport
GO:0043306 positive regulation of mast cell degranulation
GO:0045471 response to ethanol
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071635 negative regulation of transforming growth factor beta production
GO:1901215 negative regulation of neuron death
GO:1901247 negative regulation of lung ciliated cell differentiation
GO:1901251 positive regulation of lung goblet cell differentiation
GO:1903660 negative regulation of complement-dependent cytotoxicity
GO:2000231 positive regulation of pancreatic stellate cell proliferation
GO:2000352 negative regulation of endothelial cell apoptotic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009897 external side of plasma membrane


-  Descriptions from all associated GenBank mRNAs
  BC096141 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116789 IMAGE:40002686), complete cds.
BC096139 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116787 IMAGE:40002680), complete cds.
BC096138 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116786 IMAGE:40002676), complete cds.
BC096140 - Homo sapiens interleukin 13, mRNA (cDNA clone MGC:116788 IMAGE:40002684), complete cds.
X69079 - H.sapiens interleukin-13 mRNA.
AB463799 - Synthetic construct DNA, clone: pF1KB6756, Homo sapiens IL13 gene for interleukin 13, without stop codon, in Flexi system.
KJ891466 - Synthetic construct Homo sapiens clone ccsbBroadEn_00860 IL13 gene, encodes complete protein.
L06801 - Homo sapiens interleukin 13 mRNA, complete cds.
AF043334 - Homo sapiens interleukin 13 precursor (IL13) mRNA, complete cds.
FU768464 - Short interference ribonucleic acids for treating allergic diseases.
KJ901525 - Synthetic construct Homo sapiens clone ccsbBroadEn_10919 IL13 gene, encodes complete protein.
FU768463 - Short interference ribonucleic acids for treating allergic diseases.
JD460866 - Sequence 441890 from Patent EP1572962.
JD535233 - Sequence 516257 from Patent EP1572962.
JD303117 - Sequence 284141 from Patent EP1572962.
JD137333 - Sequence 118357 from Patent EP1572962.
JD162535 - Sequence 143559 from Patent EP1572962.
JD231205 - Sequence 212229 from Patent EP1572962.
JD143645 - Sequence 124669 from Patent EP1572962.
JD127599 - Sequence 108623 from Patent EP1572962.
JD391363 - Sequence 372387 from Patent EP1572962.
JD518587 - Sequence 499611 from Patent EP1572962.
JD257338 - Sequence 238362 from Patent EP1572962.
JD368427 - Sequence 349451 from Patent EP1572962.
JD468468 - Sequence 449492 from Patent EP1572962.
JD185817 - Sequence 166841 from Patent EP1572962.
JD249141 - Sequence 230165 from Patent EP1572962.
JD487162 - Sequence 468186 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_inflamPathway - Cytokines and Inflammatory Response
h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development
h_cytokinePathway - Cytokine Network
h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression

Reactome (by CSHL, EBI, and GO)

Protein P35225 (Reactome details) participates in the following event(s):

R-HSA-449818 IL13 binds IL13RA2
R-HSA-6786118 IL13 binds IL13RA:TYK2
R-HSA-6786114 IL13:IL13RA:TYK2 binds IL4R:JAK2
R-HSA-6788571 STAT1,STAT3,STAT6 bind IL13:IL13R type II
R-HSA-6788582 STAT1,STAT3,STAT6 phosphorylation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000304506.1, ENST00000304506.2, ENST00000304506.3, ENST00000304506.4, ENST00000304506.5, ENST00000304506.6, IL13_HUMAN, NC30, NM_002188, O43644, P35225, Q4VB52, Q9UDC7, uc317nlg.1, uc317nlg.2
UCSC ID: ENST00000304506.7_5
RefSeq Accession: NM_002188.3
Protein: P35225 (aka IL13_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.