Human Gene IRS4 (ENST00000372129.4_11) from GENCODE V47lift37
  Description: insulin receptor substrate 4, transcript variant 2 (from RefSeq NM_001379150.1)
Gencode Transcript: ENST00000372129.4_11
Gencode Gene: ENSG00000133124.12_14
Transcript (Including UTRs)
   Position: hg19 chrX:107,963,176-107,979,793 Size: 16,618 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chrX:107,965,749-107,979,574 Size: 13,826 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:107,963,176-107,979,793)mRNA (may differ from genome)Protein (1256 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: IRS4
Diseases sorted by gene-association score: exostosis (9), lipodystrophy, familial partial, type 2 (8), cribriform carcinoma (7), boutonneuse fever (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.30219-0.453 Picture PostScript Text
3' UTR -624.502573-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AL832136 - Homo sapiens mRNA; cDNA DKFZp686L0310 (from clone DKFZp686L0310).
AF007567 - Homo sapiens insulin receptor substrate 4 mRNA, complete cds.
JD522212 - Sequence 503236 from Patent EP1572962.
BC156977 - Synthetic construct Homo sapiens clone IMAGE:100062785, MGC:190614 insulin receptor substrate 4 (IRS4) mRNA, encodes complete protein.
BC156188 - Synthetic construct Homo sapiens clone IMAGE:100061585, MGC:190039 insulin receptor substrate 4 (IRS4) mRNA, encodes complete protein.
BC040635 - Homo sapiens, clone IMAGE:5766959, mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A804CF45, A0A804CF45_HUMAN, ENST00000372129.1, ENST00000372129.2, ENST00000372129.3, IRS4 , NM_001379150, uc318jrg.1, uc318jrg.2
UCSC ID: ENST00000372129.4_11
RefSeq Accession: NM_001379150.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.