ID:ITPR2_HUMAN DESCRIPTION: RecName: Full=Inositol 1,4,5-trisphosphate receptor type 2; AltName: Full=IP3 receptor isoform 2; Short=IP3R 2; Short=InsP3R2; AltName: Full=Type 2 inositol 1,4,5-trisphosphate receptor; Short=Type 2 InsP3 receptor; FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). SUBUNIT: Homotetramer (By similarity). Interacts with CABP1. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform Short is found in skeletal muscle and heart. DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. PTM: Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release (By similarity). MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor. SIMILARITY: Belongs to the InsP3 receptor family. SIMILARITY: Contains 5 MIR domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF01365 - RIH domain PF02815 - MIR domain PF08454 - RyR and IP3R Homology associated PF08709 - Inositol 1,4,5-trisphosphate/ryanodine receptor
SCOP Domains: 48371 - ARM repeat 100909 - IP3 receptor type 1 binding core, domain 2 82109 - MIR domain
ModBase Predicted Comparative 3D Structure on Q14571
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001666 response to hypoxia GO:0006811 ion transport GO:0006816 calcium ion transport GO:0007165 signal transduction GO:0030168 platelet activation GO:0048016 inositol phosphate-mediated signaling GO:0050796 regulation of insulin secretion GO:0051209 release of sequestered calcium ion into cytosol GO:0055085 transmembrane transport GO:0070588 calcium ion transmembrane transport GO:0071320 cellular response to cAMP GO:0071361 cellular response to ethanol GO:1903779 regulation of cardiac conduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
