Human Gene KLK3 (ENST00000326003.7_4) from GENCODE V47lift37
  Description: kallikrein related peptidase 3, transcript variant 1 (from RefSeq NM_001648.2)
Gencode Transcript: ENST00000326003.7_4
Gencode Gene: ENSG00000142515.16_10
Transcript (Including UTRs)
   Position: hg19 chr19:51,358,171-51,364,020 Size: 5,850 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:51,358,212-51,363,383 Size: 5,172 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:51,358,171-51,364,020)mRNA (may differ from genome)Protein (261 aa)
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-  Comments and Description Text from UniProtKB
  ID: Q546G3_HUMAN
DESCRIPTION: SubName: Full=Kallikrein 3, (Prostate specific antigen), isoform CRA_m; SubName: Full=Prostate specific antigen; SubName: Full=cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA; Flags: Precursor;
SIMILARITY: Belongs to the peptidase S1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KLK3
Diseases sorted by gene-association score: prostatitis (39), prostate disease (38), prostatic adenoma (34), clear cell adenocarcinoma (27), prostate adenocarcinoma (27), prostatic hypertrophy (26), urethral stricture (25), nodular prostate (24), withdrawal disorder (23), male reproductive organ cancer (22), reproductive organ cancer (21), prostate cancer (18), nephrogenic adenoma of the urethra (18), male reproductive organ benign neoplasm (17), impotence (16), lymphocele (16), gynecomastia (16), prostate sarcoma (15), prostate adenoid cystic carcinoma (15), prostate squamous cell carcinoma (15), adamantinoma of long bones (15), adenosquamous prostate carcinoma (15), urethral syndrome (15), prostate embryonal rhabdomyosarcoma (15), prostate signet ring cell adenocarcinoma (15), prostate leiomyoma (14), proctitis (14), alpha-2-macroglobulin deficiency (13), bladder adenocarcinoma (12), nephrogenic adenoma (12), rectal disease (11), breast cyst (11), prostatic acinar adenocarcinoma (11), male reproductive system disease (11), prostatic cyst (10), prostate transitional cell carcinoma (10), androgenic alopecia (10), female urethral cancer (10), villous adenoma (10), urethral benign neoplasm (9), prostate lymphoma (9), seminal vesicle adenocarcinoma (8), urethra adenocarcinoma (8), urethra clear cell adenocarcinoma (8), griscelli syndrome, type 3 (8), urinary system disease (8), small cell neuroendocrine carcinoma (8), sexual disorder (8), urinary tract obstruction (8), endodermal sinus tumor (7), cystitis cystica (7), prostate rhabdomyosarcoma (7), small cell carcinoma (7), bladder neck obstruction (6), coronary artery aneurysm (6), cystadenoma (6), acute cystitis (6), prostate small cell carcinoma (6), urethral calculus (6), paraphimosis (6), atrophy of prostate (6), radiation cystitis (6), cribriform carcinoma (5), tuberculous epididymitis (5), suprasellar meningioma (5), breast disease (5), newcastle disease (5), rete testis adenocarcinoma (5), seminal vesicle tumor (5), rete testis neoplasm (5), urethral diverticulum (5), bladder disease (5), reproductive system disease (4), prostate cancer susceptibility (4), bladder cancer, somatic (2), cell type cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2471.43 RPKM in Prostate
Total median expression: 2477.86 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.2041-0.151 Picture PostScript Text
3' UTR -201.80637-0.317 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin
PF13365 - Trypsin-like peptidase domain

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on Q546G3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis


-  Descriptions from all associated GenBank mRNAs
  S75755 - PSA=prostate-specific antigen [human, breast cancer specimen, mRNA Partial, 569 nt].
AF335477 - Homo sapiens prostate-specific antigen variant 1 mRNA, complete cds, alternatively spliced.
AF335478 - Homo sapiens prostate-specific antigen variant 2 mRNA, complete cds, alternatively spliced.
U17040 - Human prostate specific antigen precursor mRNA, complete cds.
AX772834 - Sequence 31 from Patent WO03046180.
BC005307 - Homo sapiens kallikrein-related peptidase 3, mRNA (cDNA clone MGC:12378 IMAGE:3950475), complete cds.
AX772836 - Sequence 33 from Patent WO03046180.
X05332 - Human mRNA for prostate specific antigen.
BC056665 - Homo sapiens kallikrein-related peptidase 3, mRNA (cDNA clone MGC:62050 IMAGE:4296876), complete cds.
JD120995 - Sequence 102019 from Patent EP1572962.
AJ459784 - Homo sapiens mRNA for prostate specific antigen (KLK3 gene), splice variant 3.
AJ310937 - Homo sapiens mRNA for putative preproPSA-RP2 (KLK3 gene), transcript 1.
AK311887 - Homo sapiens cDNA, FLJ92153, highly similar to Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 2, mRNA.
AK312933 - Homo sapiens cDNA, FLJ93384, Homo sapiens kallikrein 3, (prostate specific antigen) (KLK3),transcript variant 1, mRNA.
AJ310938 - Homo sapiens mRNA for putative preproPSA-RP2 (KLK3 gene), transcript 2.
AJ512346 - Homo sapiens mRNA for prostate specific antigen (KLK3 gene), splice variant RP5.
AJ459783 - Homo sapiens mRNA for prostate specific antigen (KLK3 gene), splice variant 2.
AJ459782 - Homo sapiens mRNA for prostate specific antigen (KLK3 gene), splice variant 1.
M26663 - Homo sapiens prostate-specific antigen mRNA, complete cds.
DQ890670 - Synthetic construct clone IMAGE:100003300; FLH164955.01X; RZPDo839D12158D kallikrein 3, (prostate specific antigen) (KLK3) gene, encodes complete protein.
DQ893851 - Synthetic construct Homo sapiens clone IMAGE:100008311; FLH164951.01L; RZPDo839D12157D kallikrein 3, (prostate specific antigen) (KLK3) gene, encodes complete protein.
AB463810 - Synthetic construct DNA, clone: pF1KB6333, Homo sapiens KLK3 gene for kallikrein-related peptidase 3, without stop codon, in Flexi system.
CU690730 - Synthetic construct Homo sapiens gateway clone IMAGE:100021320 5' read KLK3 mRNA.
KJ890692 - Synthetic construct Homo sapiens clone ccsbBroadEn_00086 KLK3 gene, encodes complete protein.
KJ896446 - Synthetic construct Homo sapiens clone ccsbBroadEn_05840 KLK3 gene, encodes complete protein.
BT019862 - Homo sapiens kallikrein 3, (prostate specific antigen) mRNA, complete cds.
M21897 - Human prostate specific antigen (PA) gene, 3' end, clone PA 424.
M21896 - Human prostate specific antigen (PA) gene, 3' end, clone PA 525.
M21895 - Human prostate specific antigen (PA) gene, 3' end, clone PA 75.
X07730 - Human mRNA for prostate specific antigen.
DQ641251 - Homo sapiens kallikrein 3 transcript variant (KLK3) mRNA, complete sequence; alternatively spliced.
JD566149 - Sequence 547173 from Patent EP1572962.
JD540828 - Sequence 521852 from Patent EP1572962.
X75682 - H.sapiens (TL32) mRNA from LNCaP cell line.
JD412943 - Sequence 393967 from Patent EP1572962.
JD450275 - Sequence 431299 from Patent EP1572962.
JD547477 - Sequence 528501 from Patent EP1572962.
JD482370 - Sequence 463394 from Patent EP1572962.
JD046238 - Sequence 27262 from Patent EP1572962.
JD437126 - Sequence 418150 from Patent EP1572962.
JD557738 - Sequence 538762 from Patent EP1572962.
KY508392 - Homo sapiens nonfunctional kallikrein-related peptidase 3 transcript variant 5 (KLK3) mRNA, partial sequence; alternatively spliced.
KY508393 - Homo sapiens nonfunctional kallikrein-related peptidase 3 transcript variant 6 (KLK3) mRNA, partial sequence; alternatively spliced.
KY508394 - Homo sapiens nonfunctional kallikrein-related peptidase 3 transcript variant 7 (KLK3) mRNA, partial sequence; alternatively spliced.
KY508395 - Homo sapiens nonfunctional kallikrein-related peptidase 3 transcript variant 8 (KLK3) mRNA, partial sequence; alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000326003.1, ENST00000326003.2, ENST00000326003.3, ENST00000326003.4, ENST00000326003.5, ENST00000326003.6, hCG_22929 , KLK3 , KLNA2 , NM_001648, Q546G3, Q546G3_HUMAN, uc317ryu.1, uc317ryu.2
UCSC ID: ENST00000326003.7_4
RefSeq Accession: NM_001648.2
Protein: Q546G3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.