Human Gene MTA2 (ENST00000278823.7_7) from GENCODE V47lift37
  Description: metastasis associated 1 family member 2, transcript variant 1 (from RefSeq NM_004739.4)
Gencode Transcript: ENST00000278823.7_7
Gencode Gene: ENSG00000149480.7_9
Transcript (Including UTRs)
   Position: hg19 chr11:62,360,686-62,369,337 Size: 8,652 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr11:62,361,347-62,368,922 Size: 7,576 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:62,360,686-62,369,337)mRNA (may differ from genome)Protein (668 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MTA2_HUMAN
DESCRIPTION: RecName: Full=Metastasis-associated protein MTA2; AltName: Full=Metastasis-associated 1-like 1; Short=MTA1-L1 protein; AltName: Full=p53 target protein in deacetylase complex;
FUNCTION: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
SUBUNIT: Component of the nucleosome-remodeling and histone- deacetylase multiprotein complex (NuRD). Interacts with HDAC7, p53/TP53, MINT and MBD3 (By similarity).
INTERACTION: Q99497:PARK7; NbExp=3; IntAct=EBI-1783035, EBI-1164361;
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Contains 1 BAH domain.
SIMILARITY: Contains 1 ELM2 domain.
SIMILARITY: Contains 1 GATA-type zinc finger.
SIMILARITY: Contains 1 SANT domain.
SEQUENCE CAUTION: Sequence=AAH23656.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.53 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1187.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -216.80415-0.522 Picture PostScript Text
3' UTR -246.00661-0.372 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001025 - BAH_dom
IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom
IPR000679 - Znf_GATA

Pfam Domains:
PF00320 - GATA zinc finger
PF01426 - BAH domain
PF01448 - ELM2 domain
PF17226 - MTA R1 domain

SCOP Domains:
48695 - Multiheme cytochromes
46689 - Homeodomain-like
82061 - BAH domain
53383 - PLP-dependent transferases
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on O94776
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000989 transcription factor activity, transcription factor binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0031492 nucleosomal DNA binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006306 DNA methylation
GO:0006333 chromatin assembly or disassembly
GO:0006355 regulation of transcription, DNA-templated
GO:0010762 regulation of fibroblast migration
GO:0016575 histone deacetylation
GO:0043044 ATP-dependent chromatin remodeling
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016020 membrane
GO:0016581 NuRD complex
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC053650 - Homo sapiens metastasis associated 1 family, member 2, mRNA (cDNA clone MGC:61439 IMAGE:5531965), complete cds.
CR749481 - Homo sapiens mRNA; cDNA DKFZp686F2281 (from clone DKFZp686F2281).
JD127069 - Sequence 108093 from Patent EP1572962.
JD402335 - Sequence 383359 from Patent EP1572962.
JD521511 - Sequence 502535 from Patent EP1572962.
JD154434 - Sequence 135458 from Patent EP1572962.
JD475524 - Sequence 456548 from Patent EP1572962.
JD504068 - Sequence 485092 from Patent EP1572962.
AB016591 - Homo sapiens mRNA for MTA1 like1, complete cds.
JD449689 - Sequence 430713 from Patent EP1572962.
JD451749 - Sequence 432773 from Patent EP1572962.
JD389083 - Sequence 370107 from Patent EP1572962.
JD427528 - Sequence 408552 from Patent EP1572962.
AK301569 - Homo sapiens cDNA FLJ51637 complete cds, highly similar to Metastasis-associated protein MTA2.
AF295807 - Homo sapiens p53 target protein in deacetylase complex (PID) mRNA, complete cds.
KJ892717 - Synthetic construct Homo sapiens clone ccsbBroadEn_02111 MTA2 gene, encodes complete protein.
AB527681 - Synthetic construct DNA, clone: pF1KB6213, Homo sapiens MTA2 gene for metastasis associated 1 family, member 2, without stop codon, in Flexi system.
BC023656 - Homo sapiens metastasis associated 1 family, member 2, mRNA (cDNA clone IMAGE:4762045), partial cds.
LF211236 - JP 2014500723-A/18739: Polycomb-Associated Non-Coding RNAs.
LF344818 - JP 2014500723-A/152321: Polycomb-Associated Non-Coding RNAs.
JD293787 - Sequence 274811 from Patent EP1572962.
LF344817 - JP 2014500723-A/152320: Polycomb-Associated Non-Coding RNAs.
LF344816 - JP 2014500723-A/152319: Polycomb-Associated Non-Coding RNAs.
MA580395 - JP 2018138019-A/152321: Polycomb-Associated Non-Coding RNAs.
MA580394 - JP 2018138019-A/152320: Polycomb-Associated Non-Coding RNAs.
MA580393 - JP 2018138019-A/152319: Polycomb-Associated Non-Coding RNAs.
MA446813 - JP 2018138019-A/18739: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O94776 (Reactome details) participates in the following event(s):

R-HSA-6805650 MTA2-NuRD complex deacetylates TP53
R-HSA-427404 Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene
R-HSA-8943780 SALL4 recruits NuRD to PTEN gene
R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-6807070 PTEN Regulation
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-3214815 HDACs deacetylate histones
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-74160 Gene expression (Transcription)
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-4839726 Chromatin organization
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000278823.1, ENST00000278823.2, ENST00000278823.3, ENST00000278823.4, ENST00000278823.5, ENST00000278823.6, MTA1L1, MTA2_HUMAN, NM_004739, O94776, PID, Q68DB1, Q9UQB5, uc317jpr.1, uc317jpr.2
UCSC ID: ENST00000278823.7_7
RefSeq Accession: NM_004739.4
Protein: O94776 (aka MTA2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.