Human Gene MYH1 (ENST00000226207.6_7) from GENCODE V47lift37
  Description: myosin heavy chain 1 (from RefSeq NM_005963.4)
Gencode Transcript: ENST00000226207.6_7
Gencode Gene: ENSG00000109061.10_9
Transcript (Including UTRs)
   Position: hg19 chr17:10,395,624-10,421,859 Size: 26,236 Total Exon Count: 40 Strand: -
Coding Region
   Position: hg19 chr17:10,395,733-10,419,959 Size: 24,227 Coding Exon Count: 38 

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Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:10,395,624-10,421,859)mRNA (may differ from genome)Protein (1939 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYH1_HUMAN
DESCRIPTION: RecName: Full=Myosin-1; AltName: Full=Myosin heavy chain 1; AltName: Full=Myosin heavy chain 2x; Short=MyHC-2x; AltName: Full=Myosin heavy chain IIx/d; Short=MyHC-IIx/d; AltName: Full=Myosin heavy chain, skeletal muscle, adult 1;
FUNCTION: Muscle contraction.
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
DOMAIN: Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYH1
Diseases sorted by gene-association score: retinitis pigmentosa 67 (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 836.89 RPKM in Muscle - Skeletal
Total median expression: 844.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.2094-0.151 Picture PostScript Text
3' UTR -25.90109-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR015650 - Myosin_1/23/4/7/8/13/15
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif
PF01576 - Myosin tail
PF02736 - Myosin N-terminal SH3-like domain

SCOP Domains:
50084 - Myosin S1 fragment, N-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases
53067 - Actin-like ATPase domain
53795 - PEP carboxykinase-like
90257 - Myosin rod fragments
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on P12882
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0051015 actin filament binding

Biological Process:
GO:0006936 muscle contraction
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005737 cytoplasm
GO:0005859 muscle myosin complex
GO:0014704 intercalated disc
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0031672 A band
GO:0032982 myosin filament
GO:0036464 cytoplasmic ribonucleoprotein granule


-  Descriptions from all associated GenBank mRNAs
  X03740 - Human skeletal mRNA for myosin heavy chain light meromyosin region.
AF111785 - Homo sapiens myosin heavy chain IIx/d mRNA, complete cds.
EU794637 - Homo sapiens epididymis luminal protein 71 (HEL71) mRNA, complete cds.
BC114545 - Homo sapiens myosin, heavy chain 1, skeletal muscle, adult, mRNA (cDNA clone MGC:133384 IMAGE:40070022), complete cds.
BC022376 - Homo sapiens myosin, heavy chain 1, skeletal muscle, adult, mRNA (cDNA clone IMAGE:4338358), partial cds.
AK310004 - Homo sapiens cDNA, FLJ17046.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000226207.1, ENST00000226207.2, ENST00000226207.3, ENST00000226207.4, ENST00000226207.5, MYH1_HUMAN, NM_005963, P12882, Q14CA4, Q9Y622, uc317dlc.1, uc317dlc.2
UCSC ID: ENST00000226207.6_7
RefSeq Accession: NM_005963.4
Protein: P12882 (aka MYH1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.