ID:MYZAP_HUMAN DESCRIPTION: RecName: Full=Myocardial zonula adherens protein; AltName: Full=GRINL1A upstream protein; Short=Gup; Flags: Precursor; FUNCTION: Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). SUBUNIT: Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF (By similarity). Interacts with GRIN1. Interacts with DYNLL1. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, myofibril, sarcomere, I band (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By similarity). Cell junction. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity). TISSUE SPECIFICITY: Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. MISCELLANEOUS: The adjacent MYZAP and POLR2M genes are part of a complex transcription unit. The respective transcripts derive from different promoters and are alternatively spliced. In human, some transcripts of the upstream promoter of MYZAP use exons of the downstream POLR2M gene. SIMILARITY: Belongs to the MYZAP family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
SCOP Domains: 90257 - Myosin rod fragments 57997 - Tropomyosin
ModBase Predicted Comparative 3D Structure on P0CAP1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
