ID:NDUV2_HUMAN DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; EC=1.6.5.3; EC=1.6.99.3; AltName: Full=NADH-ubiquinone oxidoreductase 24 kDa subunit; Flags: Precursor; FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol. CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor. COFACTOR: Binds 1 2Fe-2S cluster (Potential). SUBUNIT: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. SUBCELLULAR LOCATION: Mitochondrion inner membrane. SIMILARITY: Belongs to the complex I 24 kDa subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19404
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003954 NADH dehydrogenase activity GO:0005515 protein binding GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0009055 electron carrier activity GO:0016491 oxidoreductase activity GO:0046872 metal ion binding GO:0051536 iron-sulfur cluster binding GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0007399 nervous system development GO:0032981 mitochondrial respiratory chain complex I assembly GO:0048738 cardiac muscle tissue development GO:0055114 oxidation-reduction process
AK312129 - Homo sapiens cDNA, FLJ92411, Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa(NDUFV2), mRNA. BC001632 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa, mRNA (cDNA clone MGC:2144 IMAGE:3536345), complete cds. BC017487 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa, mRNA (cDNA clone MGC:15943 IMAGE:3537815), complete cds. M22538 - Human nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit mRNA, complete cds. AK291865 - Homo sapiens cDNA FLJ78041 complete cds, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2), mRNA. AB590136 - Synthetic construct DNA, clone: pFN21AE1378, Homo sapiens NDUFV2 gene for NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa, without stop codon, in Flexi system. BC071689 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa, mRNA (cDNA clone MGC:87932 IMAGE:4372795), complete cds. DQ895813 - Synthetic construct Homo sapiens clone IMAGE:100010273; FLH187898.01L; RZPDo839E04149D NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2) gene, encodes complete protein. DQ892593 - Synthetic construct clone IMAGE:100005223; FLH187902.01X; RZPDo839E04150D NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa (NDUFV2) gene, encodes complete protein. KJ891684 - Synthetic construct Homo sapiens clone ccsbBroadEn_01078 NDUFV2 gene, encodes complete protein. CR456928 - Homo sapiens full open reading frame cDNA clone RZPDo834G1215D for gene NDUFV2, NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa; complete cds, incl. stopcodon. DL492013 - Novel nucleic acids. DL490565 - Novel nucleic acids. AF147367 - Homo sapiens full length insert cDNA clone YB64B12.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein P19404 (Reactome details) participates in the following event(s):
R-HSA-6800870 NDUF subunits bind to form the FP subcomplex R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-HSA-6799198 Complex I biogenesis R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
