Human Gene NPY4R (ENST00000374312.5_6) from GENCODE V47lift37
  Description: neuropeptide Y receptor Y4, transcript variant 1 (from RefSeq NM_005972.6)
Gencode Transcript: ENST00000374312.5_6
Gencode Gene: ENSG00000204174.8_10
Transcript (Including UTRs)
   Position: hg19 chr10:47,083,457-47,088,320 Size: 4,864 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr10:47,086,784-47,087,911 Size: 1,128 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:47,083,457-47,088,320)mRNA (may differ from genome)Protein (375 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPY4R_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide Y receptor type 4; Short=NPY4-R; AltName: Full=Pancreatic polypeptide receptor 1; Short=PP1;
FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.63 RPKM in Colon - Transverse
Total median expression: 13.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -203.20496-0.410 Picture PostScript Text
3' UTR -161.40409-0.395 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR001933 - NPY4_rcpt
IPR000611 - NPY_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2IK5 - Model


ModBase Predicted Comparative 3D Structure on P50391
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001602 pancreatic polypeptide receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
GO:0017046 peptide hormone binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY649985 - Homo sapiens chromosome 10 pancreatic polypeptide receptor 1 (PPYR1) mRNA, complete cds, alternatively spliced.
AY649986 - Homo sapiens chromosome 10 pancreatic polypeptide receptor 1 (PPYR1) mRNA, complete cds, alternatively spliced.
U42387 - Homo sapiens pancreatic polypeptide receptor mRNA, complete cds.
BC096237 - Homo sapiens pancreatic polypeptide receptor 1, mRNA (cDNA clone IMAGE:40005500), containing frame-shift errors.
BC096238 - Homo sapiens pancreatic polypeptide receptor 1, mRNA (cDNA clone MGC:116895 IMAGE:40005502), complete cds.
BC099637 - Homo sapiens pancreatic polypeptide receptor 1, mRNA (cDNA clone MGC:116897 IMAGE:40005506), complete cds.
KJ897368 - Synthetic construct Homo sapiens clone ccsbBroadEn_06762 PPYR1 gene, encodes complete protein.
AB464649 - Synthetic construct DNA, clone: pF1KB9847, Homo sapiens PPYR1 gene for pancreatic polypeptide receptor 1, without stop codon, in Flexi system.
CR541950 - Homo sapiens full open reading frame cDNA clone RZPDo834D1234D for gene PPYR1, pancreatic polypeptide receptor 1; complete cds, without stopcodon.
JD228089 - Sequence 209113 from Patent EP1572962.
JD494463 - Sequence 475487 from Patent EP1572962.
JD226795 - Sequence 207819 from Patent EP1572962.
JD267181 - Sequence 248205 from Patent EP1572962.
JD428719 - Sequence 409743 from Patent EP1572962.
JD078509 - Sequence 59533 from Patent EP1572962.
JD491862 - Sequence 472886 from Patent EP1572962.
JD374771 - Sequence 355795 from Patent EP1572962.
JD263534 - Sequence 244558 from Patent EP1572962.
JD452981 - Sequence 434005 from Patent EP1572962.
JD061250 - Sequence 42274 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P50391 (Reactome details) participates in the following event(s):

R-HSA-388863 Neuropeptide Y receptors can bind neuropeptide Y-related peptides
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000374312.1, ENST00000374312.2, ENST00000374312.3, ENST00000374312.4, NM_005972, NPY4R_HUMAN, P50391, PPYR1, Q13456, Q5ISU3, Q5T2X9, Q6FH06, uc318lmf.1, uc318lmf.2
UCSC ID: ENST00000374312.5_6
RefSeq Accession: NM_005972.6
Protein: P50391 (aka NPY4R_HUMAN or NY4R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.