Human Gene NTRK3 (ENST00000629765.3_7) from GENCODE V47lift37
  Description: neurotrophic receptor tyrosine kinase 3, transcript variant 7 (from RefSeq NM_001375810.1)
Gencode Transcript: ENST00000629765.3_7
Gencode Gene: ENSG00000140538.17_13
Transcript (Including UTRs)
   Position: hg19 chr15:88,402,982-88,799,970 Size: 396,989 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr15:88,420,166-88,799,384 Size: 379,219 Coding Exon Count: 18 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:88,402,982-88,799,970)mRNA (may differ from genome)Protein (839 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NTRK3
Diseases sorted by gene-association score: cerebral sarcoma* (350), differentiated thyroid carcinoma* (350), congenital mesoblastic nephroma* (266), congenital fibrosarcoma (25), pediatric fibrosarcoma (18), fibrosarcoma (17), breast secretory carcinoma (17), cellular congenital mesoblastic nephroma (17), adult fibrosarcoma (16), adult mesoblastic nephroma (16), birth defects (13), medulloblastoma (12), childhood medulloblastoma (9), mast-cell leukemia (9), gastrointestinal stromal tumor (9), spindle cell sarcoma (9), type c thymoma (8), adenocarcinoma (7), hypertrophic pyloric stenosis (7), anhidrosis (7), pyloric stenosis (6), malignant mesenchymoma (5), mast cell neoplasm (5), polymorphous low-grade adenocarcinoma (5), infratentorial cancer (5), cerebral cavernous malformations-2 (4), tetralogy of fallot (2), hirschsprung disease 1 (2), breast cancer (2), connective tissue cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -143.80314-0.458 Picture PostScript Text
3' UTR -5107.9017184-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  S76475 - trkC [human, brain, mRNA, 2715 nt].
AF041811 - Homo sapiens ETS related protein-growth factor receptor tyrosine kinase fusion proteins (ETV6-NTRK3 fusion) mRNA, partial cds.
AK297160 - Homo sapiens cDNA FLJ60676 complete cds, highly similar to NT-3 growth factor receptor precursor (EC 2.7.10.1).
AF052184 - Homo sapiens clone 24817 mRNA sequence.
U05012 - Homo sapiens receptor tyrosine kinase TrkC (NTRK3) mRNA, complete cds.
AF125808 - Homo sapiens ETS related protein-neurotrophic receptor tyrosine kinase fusion protein (ETV6-NTRK3 fusion) mRNA, partial cds.
AK313646 - Homo sapiens cDNA, FLJ94223.
KJ534904 - Homo sapiens clone NTRK3_iso-B_adult-A01 neurotrophic tyrosine kinase receptor type 3 isoform B (NTRK3) mRNA, partial cds, alternatively spliced.
KJ534905 - Homo sapiens clone NTRK3_iso-C_adult-A02 neurotrophic tyrosine kinase receptor type 3 isoform C (NTRK3) mRNA, partial cds, alternatively spliced.
KJ534906 - Homo sapiens clone NTRK3_iso-D_fetal-F07 neurotrophic tyrosine kinase receptor type 3 isoform D (NTRK3) mRNA, partial cds, alternatively spliced.
KJ535052 - Homo sapiens clone NTRK3_iso-A_fetal-F14 neurotrophic tyrosine kinase receptor type 3 isoform A (NTRK3) mRNA, complete cds, alternatively spliced.
AK302504 - Homo sapiens cDNA FLJ55664 complete cds, highly similar to NT-3 growth factor receptor precursor (EC2.7.10.1).
AK309695 - Homo sapiens cDNA, FLJ99736.
S76476 - trkC {alternatively spliced} [human, brain, mRNA, 2225 nt].
BC013693 - Homo sapiens neurotrophic tyrosine kinase, receptor, type 3, mRNA (cDNA clone MGC:17113 IMAGE:4181574), complete cds.
BT007291 - Homo sapiens neurotrophic tyrosine kinase, receptor, type 3 mRNA, complete cds.
KJ897266 - Synthetic construct Homo sapiens clone ccsbBroadEn_06660 NTRK3 gene, encodes complete protein.
AB384872 - Synthetic construct DNA, clone: pF1KB3902, Homo sapiens NTRK3 gene for NT-3 growth factor receptor precursor, complete cds, without stop codon, in Flexi system.
AF125809 - Homo sapiens neurotrophic receptor tyrosine kinase-ETS related protein fusion protein (NTRK3-ETV6 fusion) mRNA, partial cds.
CU680654 - Synthetic construct Homo sapiens gateway clone IMAGE:100020771 5' read NTRK3 mRNA.
AL109700 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 51358.
AK094929 - Homo sapiens cDNA FLJ37610 fis, clone BRCOC2011398.
AL109696 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 21920.
DQ571824 - Homo sapiens piRNA piR-31936, complete sequence.
DQ571825 - Homo sapiens piRNA piR-31937, complete sequence.
DQ571826 - Homo sapiens piRNA piR-31938, complete sequence.
JD399712 - Sequence 380736 from Patent EP1572962.
JD132828 - Sequence 113852 from Patent EP1572962.
JD398540 - Sequence 379564 from Patent EP1572962.
JD528175 - Sequence 509199 from Patent EP1572962.
JD314872 - Sequence 295896 from Patent EP1572962.
AY065844 - Homo sapiens truncated receptor tyrosine kinase TrkC mRNA, partial cds.
AF058390 - Homo sapiens neurotrophin 3 receptor truncated isoform (NTRK3) mRNA, partial cds.
DQ323596 - Homo sapiens clone 5 tyrosine kinase receptor isoform C mRNA, partial cds.
AF058389 - Homo sapiens neurotrophin 3 receptor (NTRK3) mRNA, partial cds.
BC128249 - Homo sapiens olfactory receptor, family 1, subfamily A, member 1, mRNA (cDNA clone IMAGE:40114772).
JD235415 - Sequence 216439 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000629765.1, ENST00000629765.2, hCG_26627 , NM_001375810, NTRK3 , uc327zlb.1, uc327zlb.2, X5D2R1, X5D2R1_HUMAN
UCSC ID: ENST00000629765.3_7
RefSeq Accession: NM_001012338.3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.