Human Gene ONECUT3 (ENST00000382349.5_4) from GENCODE V47lift37
  Description: one cut homeobox 3 (from RefSeq NM_001080488.2)
Gencode Transcript: ENST00000382349.5_4
Gencode Gene: ENSG00000205922.5_7
Transcript (Including UTRs)
   Position: hg19 chr19:1,753,505-1,780,987 Size: 27,483 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr19:1,753,662-1,775,444 Size: 21,783 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:1,753,505-1,780,987)mRNA (may differ from genome)Protein (494 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ONEC3_HUMAN
DESCRIPTION: RecName: Full=One cut domain family member 3; AltName: Full=One cut homeobox 3; AltName: Full=Transcription factor ONECUT-3; Short=OC-3;
FUNCTION: Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 CUT DNA-binding domain.
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ONECUT3
Diseases sorted by gene-association score: dracunculiasis (2)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.00 RPKM in Testis
Total median expression: 1.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.30157-0.556 Picture PostScript Text
3' UTR -2270.115543-0.410 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003350 - Hmoeo_CUT
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like
IPR010982 - Lambda_DNA-bd_dom

Pfam Domains:
PF00046 - Homeodomain
PF02376 - CUT domain

SCOP Domains:
101447 - Formin homology 2 domain (FH2 domain)
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on O60422
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048731 system development

Cellular Component:
GO:0005634 nucleus
GO:0005667 transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  JC506674 - Sequence 42 from Patent EP2733220.
JC506688 - Sequence 56 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC737800 - Sequence 56 from Patent WO2014075939.
JD513821 - Sequence 494845 from Patent EP1572962.
JD226420 - Sequence 207444 from Patent EP1572962.
JD123321 - Sequence 104345 from Patent EP1572962.
JD115999 - Sequence 97023 from Patent EP1572962.
JD240417 - Sequence 221441 from Patent EP1572962.
AK074606 - Homo sapiens cDNA FLJ90125 fis, clone HEMBA1007291.
JD464281 - Sequence 445305 from Patent EP1572962.
JD233710 - Sequence 214734 from Patent EP1572962.
JD490206 - Sequence 471230 from Patent EP1572962.
JD249303 - Sequence 230327 from Patent EP1572962.
JD088921 - Sequence 69945 from Patent EP1572962.
JD215642 - Sequence 196666 from Patent EP1572962.
JD064269 - Sequence 45293 from Patent EP1572962.
JD215620 - Sequence 196644 from Patent EP1572962.
JD440205 - Sequence 421229 from Patent EP1572962.
JD328545 - Sequence 309569 from Patent EP1572962.
JD321322 - Sequence 302346 from Patent EP1572962.
JD546973 - Sequence 527997 from Patent EP1572962.
JD140169 - Sequence 121193 from Patent EP1572962.
JD489287 - Sequence 470311 from Patent EP1572962.
JD246807 - Sequence 227831 from Patent EP1572962.
JD049780 - Sequence 30804 from Patent EP1572962.
JD362270 - Sequence 343294 from Patent EP1572962.
JD446736 - Sequence 427760 from Patent EP1572962.
JD373686 - Sequence 354710 from Patent EP1572962.
JD074550 - Sequence 55574 from Patent EP1572962.
JD238285 - Sequence 219309 from Patent EP1572962.
JD243154 - Sequence 224178 from Patent EP1572962.
JD430051 - Sequence 411075 from Patent EP1572962.
JD183942 - Sequence 164966 from Patent EP1572962.
JD558935 - Sequence 539959 from Patent EP1572962.
JD537865 - Sequence 518889 from Patent EP1572962.
JD258755 - Sequence 239779 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O60422 (Reactome details) participates in the following event(s):

R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
R-HSA-186712 Regulation of beta-cell development
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: A8MZM7, ENST00000382349.1, ENST00000382349.2, ENST00000382349.3, ENST00000382349.4, NM_001080488, O60422, ONEC3_HUMAN, uc318quf.1, uc318quf.2
UCSC ID: ENST00000382349.5_4
RefSeq Accession: NM_001080488.2
Protein: O60422 (aka ONEC3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.