ID:PARP2_HUMAN DESCRIPTION: RecName: Full=Poly [ADP-ribose] polymerase 2; Short=PARP-2; Short=hPARP-2; EC=2.4.2.30; AltName: Full=ADP-ribosyltransferase diphtheria toxin-like 2; Short=ARTD2; AltName: Full=NAD(+) ADP-ribosyltransferase 2; Short=ADPRT-2; AltName: Full=Poly[ADP-ribose] synthase 2; Short=pADPRT-2; FUNCTION: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. CATALYTIC ACTIVITY: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus. PTM: Poly-ADP-ribosylated by PARP1 (By similarity). SIMILARITY: Contains 1 PARP alpha-helical domain. SIMILARITY: Contains 1 PARP catalytic domain. SEQUENCE CAUTION: Sequence=AAD29857.1; Type=Erroneous initiation; Sequence=AAL77437.1; Type=Erroneous gene model prediction; Sequence=CAB41505.2; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adprtl2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UGN5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003910 DNA ligase (ATP) activity GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0005515 protein binding GO:0016740 transferase activity GO:0016757 transferase activity, transferring glycosyl groups GO:1990404 protein ADP-ribosylase activity
Biological Process: GO:0006273 lagging strand elongation GO:0006281 DNA repair GO:0006284 base-excision repair GO:0006471 protein ADP-ribosylation GO:0018312 peptidyl-serine ADP-ribosylation GO:0051103 DNA ligation involved in DNA repair GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development GO:0097191 extrinsic apoptotic signaling pathway GO:1901215 negative regulation of neuron death
LF384983 - JP 2014500723-A/192486: Polycomb-Associated Non-Coding RNAs. AK300971 - Homo sapiens cDNA FLJ58629 complete cds, highly similar to Poly (ADP-ribose) polymerase 2 (EC 2.4.2.30). AK290079 - Homo sapiens cDNA FLJ75509 complete cds, highly similar to Homo sapiens mRNA for poly-(ADP-ribose) polymerase II. AK001980 - Homo sapiens cDNA FLJ11118 fis, clone PLACE1006011, highly similar to Homo sapiens mRNA for poly(ADP-ribose) polymerase-2. BC172288 - Synthetic construct Homo sapiens clone IMAGE:100068982, MGC:198993 poly (ADP-ribose) polymerase 2 (PARP2) mRNA, encodes complete protein. AJ236912 - Homo sapiens mRNA for poly-(ADP-ribose) polymerase II. AF085734 - Homo sapiens NAD+ ADP-ribosyltransferase 2 (ADPRT2) mRNA, complete cds. JD451977 - Sequence 433001 from Patent EP1572962. AJ236876 - Homo sapiens mRNA for poly(ADP-ribose) polymerase-2. LF334327 - JP 2014500723-A/141830: Polycomb-Associated Non-Coding RNAs. JD301893 - Sequence 282917 from Patent EP1572962. LF334329 - JP 2014500723-A/141832: Polycomb-Associated Non-Coding RNAs. LF334330 - JP 2014500723-A/141833: Polycomb-Associated Non-Coding RNAs. LF334332 - JP 2014500723-A/141835: Polycomb-Associated Non-Coding RNAs. LF334333 - JP 2014500723-A/141836: Polycomb-Associated Non-Coding RNAs. LF334334 - JP 2014500723-A/141837: Polycomb-Associated Non-Coding RNAs. JD348792 - Sequence 329816 from Patent EP1572962. LF334335 - JP 2014500723-A/141838: Polycomb-Associated Non-Coding RNAs. JD429914 - Sequence 410938 from Patent EP1572962. MA620560 - JP 2018138019-A/192486: Polycomb-Associated Non-Coding RNAs. MA569904 - JP 2018138019-A/141830: Polycomb-Associated Non-Coding RNAs. MA569906 - JP 2018138019-A/141832: Polycomb-Associated Non-Coding RNAs. MA569907 - JP 2018138019-A/141833: Polycomb-Associated Non-Coding RNAs. MA569909 - JP 2018138019-A/141835: Polycomb-Associated Non-Coding RNAs. MA569910 - JP 2018138019-A/141836: Polycomb-Associated Non-Coding RNAs. MA569911 - JP 2018138019-A/141837: Polycomb-Associated Non-Coding RNAs. MA569912 - JP 2018138019-A/141838: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UGN5 (Reactome details) participates in the following event(s):
R-HSA-5649873 PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site R-HSA-5687484 PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site R-HSA-5696664 PARP1 or PARP2 binds DDB2 at GG-NER site R-HSA-5651828 PARG dePARylates PARP1,PARP2 R-HSA-5651739 PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB R-HSA-5687653 PARP1,PARP2 dimers bound to MMEJ sites autoPARylate R-HSA-5690988 3'-incision of DNA by ERCC5 (XPG) in GG-NER R-HSA-5649883 POLB-mediated DNA strand displacement synthesis R-HSA-5651723 PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate R-HSA-5687640 POLQ extends annealed 3'-ssDNA overhangs in MMEJ R-HSA-5696655 PARP1 or PARP2 PARylates DDB2 and autoPARylates R-HSA-5690213 DNA polymerases delta, epsilon or kappa bind the GG-NER site R-HSA-6790454 SUMOylation of XPC R-HSA-5690996 ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA R-HSA-5690990 5'- incision of DNA by ERCC1:ERCC4 in GG-NER R-HSA-5691000 TFIIH binds GG-NER site to form a verification complex R-HSA-6790487 RNF111 ubiquitinates SUMOylated XPC R-HSA-5689317 Formation of the pre-incision complex in GG-NER R-HSA-5696670 CHD1L is recruited to GG-NER site R-HSA-5689861 Recruitment of XPA and release of CAK R-HSA-5690991 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-5685939 HDR through MMEJ (alt-NHEJ) R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-5696400 Dual Incision in GG-NER R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-5693538 Homology Directed Repair R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5696395 Formation of Incision Complex in GG-NER R-HSA-73933 Resolution of Abasic Sites (AP sites) R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-5696398 Nucleotide Excision Repair R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
