ID:PPP6_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 6 catalytic subunit; Short=PP6C; EC=3.1.3.16; FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 iron ion per subunit (By similarity). COFACTOR: Binds 1 manganese ion per subunit (By similarity). SUBUNIT: Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with IGBP1, MAP3K7, NFKBIE, PPP6R1, PPP6R2 and PPP6R3. INTERACTION: O15084:ANKRD28; NbExp=3; IntAct=EBI-359751, EBI-359567; P78318:IGBP1; NbExp=8; IntAct=EBI-359751, EBI-1055954; Q9UPN7:PPP6R1; NbExp=5; IntAct=EBI-359751, EBI-359745; O75170:PPP6R2; NbExp=2; IntAct=EBI-359751, EBI-359739; Q5H9R7:PPP6R3; NbExp=2; IntAct=EBI-359751, EBI-355498; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. INDUCTION: Regulated by IL2/interleukin-2 in peripheral blood T cells. SIMILARITY: Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00743
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
