Human Gene PXMP2 (ENST00000317479.8_4) from GENCODE V47lift37
  Description: peroxisomal membrane protein 2 (from RefSeq NM_018663.3)
Gencode Transcript: ENST00000317479.8_4
Gencode Gene: ENSG00000176894.10_10
Transcript (Including UTRs)
   Position: hg19 chr12:133,264,173-133,281,571 Size: 17,399 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr12:133,264,257-133,281,273 Size: 17,017 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:133,264,173-133,281,571)mRNA (may differ from genome)Protein (195 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PXMP2_HUMAN
DESCRIPTION: RecName: Full=Peroxisomal membrane protein 2; AltName: Full=22 kDa peroxisomal membrane protein;
FUNCTION: Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
SUBUNIT: Interacts with PEX19 and SIVA1.
INTERACTION: O15304:SIVA1; NbExp=3; IntAct=EBI-1392944, EBI-520756;
SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.92 RPKM in Liver
Total median expression: 360.51 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.4084-0.588 Picture PostScript Text
3' UTR -85.80298-0.288 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007248 - Mpv17_PMP22

Pfam Domains:
PF04117 - Mpv17 / PMP22 family

ModBase Predicted Comparative 3D Structure on Q9NR77
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  AF250136 - Homo sapiens 22kDa peroxisomal membrane protein-like mRNA, complete cds.
JD405867 - Sequence 386891 from Patent EP1572962.
BC073997 - Homo sapiens peroxisomal membrane protein 2, 22kDa, mRNA (cDNA clone MGC:87947 IMAGE:6171609), complete cds.
AY044439 - Homo sapiens 22 kDa peroxisomal membrane protein 2 (PXMP2) mRNA, complete cds.
AK301831 - Homo sapiens cDNA FLJ54922 complete cds.
JD084762 - Sequence 65786 from Patent EP1572962.
JD353278 - Sequence 334302 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NR77 (Reactome details) participates in the following event(s):

R-HSA-8953430 PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000317479.1, ENST00000317479.2, ENST00000317479.3, ENST00000317479.4, ENST00000317479.5, ENST00000317479.6, ENST00000317479.7, NM_018663, PMP22, PXMP2_HUMAN, Q9NR77, uc317qgb.1, uc317qgb.2
UCSC ID: ENST00000317479.8_4
RefSeq Accession: NM_018663.3
Protein: Q9NR77 (aka PXMP2_HUMAN or PMP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.