ID:RAP1B_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rap-1b; AltName: Full=GTP-binding protein smg p21B; Flags: Precursor; FUNCTION: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. ENZYME REGULATION: Activated by binding to the GTPase-activating protein RAP1GAP. Activated by guanine nucleotide-exchange factor (GEF) EPAC2 in a cAMP-dependent manner. SUBUNIT: Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1. SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction. SIMILARITY: Belongs to the small GTPase superfamily. Ras family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAP1BID273.html"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/rap1b/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P61224
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK312371 - Homo sapiens cDNA, FLJ92694, Homo sapiens RAP1B, member of RAS oncogene family (RAP1B), mRNA. BC078173 - Homo sapiens RAP1B, member of RAS oncogene family, mRNA (cDNA clone MGC:87966 IMAGE:6015817), complete cds. AK316447 - Homo sapiens cDNA, FLJ79346 complete cds, highly similar to Ras-related protein Rap-1b precursor. AJ420497 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1916608. AK316543 - Homo sapiens cDNA, FLJ79442 complete cds, highly similar to Ras-related protein Rap-1b precursor. AK298818 - Homo sapiens cDNA FLJ51696 complete cds, highly similar to Ras-related protein Rap-1b precursor. AK301401 - Homo sapiens cDNA FLJ50711 complete cds, moderately similar to Ras-related protein Rap-1b precursor. AK301428 - Homo sapiens cDNA FLJ50714 complete cds, moderately similar to Ras-related protein Rap-1b precursor. AL080212 - Homo sapiens mRNA; cDNA DKFZp586H0723 (from clone DKFZp586H0723). AK311559 - Homo sapiens cDNA, FLJ18601. BC095467 - Homo sapiens RAP1B, member of RAS oncogene family, mRNA (cDNA clone MGC:111368 IMAGE:30523718), complete cds. AB062128 - Homo sapiens OK/SW-cl.11 mRNA for RAS oncogene family member RAP1B, complete cds. BC000176 - Homo sapiens RAP1B, member of RAS oncogene family, mRNA (cDNA clone MGC:5214 IMAGE:2900837), complete cds. AF279894 - Homo sapiens PNAS-140 mRNA, partial cds. JD195842 - Sequence 176866 from Patent EP1572962. JD057470 - Sequence 38494 from Patent EP1572962. JD156379 - Sequence 137403 from Patent EP1572962. X08004 - Human mRNA for Rap1B protein. JD021224 - Sequence 2248 from Patent EP1572962. AM393243 - Synthetic construct Homo sapiens clone IMAGE:100002490 for hypothetical protein (RAP1B gene). DQ583925 - Homo sapiens piRNA piR-51037, complete sequence. AB463211 - Synthetic construct DNA, clone: pF1KB8620, Homo sapiens RAP1B gene for RAP1B, member of RAS oncogene family, without stop codon, in Flexi system. CR407689 - Homo sapiens full open reading frame cDNA clone RZPDo834E013D for gene RAP1B, RAP1B, member of RAS oncogene family complete cds, without stopcodon. BT020093 - Homo sapiens RAP1B, member of RAS oncogene family mRNA, complete cds. AF493913 - Homo sapiens Ras family small GTP binding protein RAP1B (RAL1B) mRNA, complete cds. JD031894 - Sequence 12918 from Patent EP1572962. AK127392 - Homo sapiens cDNA FLJ45481 fis, clone BRTHA2001370. JD202006 - Sequence 183030 from Patent EP1572962. JD082896 - Sequence 63920 from Patent EP1572962. JD438714 - Sequence 419738 from Patent EP1572962. JD163078 - Sequence 144102 from Patent EP1572962. JD281050 - Sequence 262074 from Patent EP1572962. JD165998 - Sequence 147022 from Patent EP1572962. JD260710 - Sequence 241734 from Patent EP1572962. JD090757 - Sequence 71781 from Patent EP1572962. JD101922 - Sequence 82946 from Patent EP1572962. JD185863 - Sequence 166887 from Patent EP1572962. JD481354 - Sequence 462378 from Patent EP1572962. JD481355 - Sequence 462379 from Patent EP1572962. JD489080 - Sequence 470104 from Patent EP1572962. JD396175 - Sequence 377199 from Patent EP1572962. JD514084 - Sequence 495108 from Patent EP1572962. JD070106 - Sequence 51130 from Patent EP1572962. JD416224 - Sequence 397248 from Patent EP1572962. JD397132 - Sequence 378156 from Patent EP1572962. JD414971 - Sequence 395995 from Patent EP1572962. JD312193 - Sequence 293217 from Patent EP1572962. JD346680 - Sequence 327704 from Patent EP1572962. JD466378 - Sequence 447402 from Patent EP1572962. JD425263 - Sequence 406287 from Patent EP1572962. JD370176 - Sequence 351200 from Patent EP1572962. JD264179 - Sequence 245203 from Patent EP1572962. JD438897 - Sequence 419921 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_metPathway - Signaling of Hepatocyte Growth Factor Receptor h_ephA4Pathway - Eph Kinases and ephrins support platelet aggregation
Reactome (by CSHL, EBI, and GO)
Protein P61224 (Reactome details) participates in the following event(s):
R-HSA-6798739 Exocytosis of azurophil granule membrane proteins R-HSA-354173 Activation of Rap1 by cytosolic GEFs R-HSA-939265 Activation of Rap1 by membrane-associated GEFs R-HSA-8875568 RAPGEF1 activates RAP1 R-HSA-392513 Rap1 signal termination by Rap1GAPs R-HSA-354060 Translocation of RIAM to plasma membrane R-HSA-392835 Rap1 sequesters Raf1 to inhibit ERK cascade R-HSA-354097 Activation of Talin R-HSA-354077 Integrin alphaIIb beta3 activation R-HSA-354149 Interaction of integrin alphaIIb beta3 with Fibrinogen R-HSA-432096 Activated integrin alphaIIb beta3 binds SHC1 R-HSA-377643 Dephosphorylation of inactive SRC by PTPB1 R-HSA-377644 Release of CSK from SRC R-HSA-377641 Clustering of Integrin alphaIIb beta3 complexes R-HSA-377640 Autophosphorylation of SRC R-HSA-354066 Translocation of FADK1 to Focal complexes R-HSA-429415 SYK binds to integrin alphaIIb beta3 R-HSA-354087 Recruitment of GRB2 to p-FADK1 R-HSA-372705 Recruitment of p130Cas to FADK1 R-HSA-354124 Phosphorylation of pFADK1 by SRC R-HSA-354073 Autophosphorylation of FADK1 at Y397 R-HSA-429441 SYK activation by SRC R-HSA-354165 Interaction of SOS with GRB2 bound to FADK1 R-HSA-372697 Crk binding to p130cas R-HSA-372693 Phosphorylation of p130Cas by SRC-FADK1 complex R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs R-HSA-5672980 Dissociation of RAS:RAF complex R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6803227 Dissociation of high activity BRAF complexes R-HSA-6803230 Dissociation of moderate activity BRAF complexes R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes R-HSA-5672978 RAF phosphorylates MAP2K dimer R-HSA-5672973 MAP2Ks phosphorylate MAPKs R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-6798695 Neutrophil degranulation R-HSA-9020591 Interleukin-12 signaling R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-392517 Rap1 signalling R-HSA-8875555 MET activates RAP1 and RAC1 R-HSA-168249 Innate Immune System R-HSA-447115 Interleukin-12 family signaling R-HSA-76009 Platelet Aggregation (Plug Formation) R-HSA-9006921 Integrin signaling R-HSA-1280218 Adaptive Immune System R-HSA-8875878 MET promotes cell motility R-HSA-168256 Immune System R-HSA-449147 Signaling by Interleukins R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-162582 Signal Transduction R-HSA-6806834 Signaling by MET R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-109582 Hemostasis R-HSA-9006934 Signaling by Receptor Tyrosine Kinases R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6802957 Oncogenic MAPK signaling R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-5663202 Diseases of signal transduction R-HSA-5683057 MAPK family signaling cascades R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
