Human Gene RBM34 (ENST00000408888.8_7) from GENCODE V47lift37
  Description: RNA binding motif protein 34, transcript variant 7 (from RefSeq NR_144492.2)
Gencode Transcript: ENST00000408888.8_7
Gencode Gene: ENSG00000188739.15_10
Transcript (Including UTRs)
   Position: hg19 chr1:235,294,498-235,324,565 Size: 30,068 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr1:235,295,028-235,324,541 Size: 29,514 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:235,294,498-235,324,565)mRNA (may differ from genome)Protein (430 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RBM34_HUMAN
DESCRIPTION: RecName: Full=RNA-binding protein 34; AltName: Full=RNA-binding motif protein 34;
SUBCELLULAR LOCATION: Nucleus, nucleolus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the RRM RBM34 family.
SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
SEQUENCE CAUTION: Sequence=AAH29451.1; Type=Erroneous initiation; Sequence=BAA07503.1; Type=Erroneous initiation; Sequence=BAF85051.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RBM34
Diseases sorted by gene-association score: spherocytosis, type 1 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.07 RPKM in Fallopian Tube
Total median expression: 0.07 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.0024-0.042 Picture PostScript Text
3' UTR -159.70530-0.301 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012677 - Nucleotide-bd_a/b_plait
IPR000504 - RRM_dom

Pfam Domains:
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

SCOP Domains:
54928 - RNA-binding domain, RBD

ModBase Predicted Comparative 3D Structure on P42696
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  JD496170 - Sequence 477194 from Patent EP1572962.
JD211671 - Sequence 192695 from Patent EP1572962.
JD426766 - Sequence 407790 from Patent EP1572962.
JD489159 - Sequence 470183 from Patent EP1572962.
JD558608 - Sequence 539632 from Patent EP1572962.
AK292362 - Homo sapiens cDNA FLJ75796 complete cds, highly similar to Homo sapiens RNA binding motif protein 34 (RBM34), mRNA.
JD163288 - Sequence 144312 from Patent EP1572962.
JD548718 - Sequence 529742 from Patent EP1572962.
JD376493 - Sequence 357517 from Patent EP1572962.
BC029451 - Homo sapiens RNA binding motif protein 34, mRNA (cDNA clone MGC:32727 IMAGE:4809263), complete cds.
GQ900966 - Homo sapiens clone HEL-T-78 epididymis secretory sperm binding protein mRNA, complete cds.
AL133010 - Homo sapiens mRNA; cDNA DKFZp434P176 (from clone DKFZp434P176).
JD297926 - Sequence 278950 from Patent EP1572962.
HQ447603 - Synthetic construct Homo sapiens clone IMAGE:100070948; CCSB013269_01 RNA binding motif protein 34 (RBM34) gene, encodes complete protein.
KJ902266 - Synthetic construct Homo sapiens clone ccsbBroadEn_11660 RBM34 gene, encodes complete protein.
AB587533 - Synthetic construct DNA, clone: pF1KE0754, Homo sapiens RBM34 gene for RNA binding motif protein 34, without stop codon, in Flexi system.
LF375430 - JP 2014500723-A/182933: Polycomb-Associated Non-Coding RNAs.
JD544059 - Sequence 525083 from Patent EP1572962.
JD305530 - Sequence 286554 from Patent EP1572962.
LF375431 - JP 2014500723-A/182934: Polycomb-Associated Non-Coding RNAs.
D38491 - Homo sapiens KIAA0117 mRNA.
LF384505 - JP 2014500723-A/192008: Polycomb-Associated Non-Coding RNAs.
LF375436 - JP 2014500723-A/182939: Polycomb-Associated Non-Coding RNAs.
CU688656 - Synthetic construct Homo sapiens gateway clone IMAGE:100022283 5' read RBM34 mRNA.
LF375437 - JP 2014500723-A/182940: Polycomb-Associated Non-Coding RNAs.
LF375438 - JP 2014500723-A/182941: Polycomb-Associated Non-Coding RNAs.
JD541788 - Sequence 522812 from Patent EP1572962.
JD338696 - Sequence 319720 from Patent EP1572962.
MA620082 - JP 2018138019-A/192008: Polycomb-Associated Non-Coding RNAs.
MA611007 - JP 2018138019-A/182933: Polycomb-Associated Non-Coding RNAs.
MA611008 - JP 2018138019-A/182934: Polycomb-Associated Non-Coding RNAs.
MA611013 - JP 2018138019-A/182939: Polycomb-Associated Non-Coding RNAs.
MA611014 - JP 2018138019-A/182940: Polycomb-Associated Non-Coding RNAs.
MA611015 - JP 2018138019-A/182941: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8J7, ENST00000408888.1, ENST00000408888.2, ENST00000408888.3, ENST00000408888.4, ENST00000408888.5, ENST00000408888.6, ENST00000408888.7, KIAA0117, NR_144492, P42696, Q8N2Z8, Q9H5A1, RBM34_HUMAN, uc319fbi.1, uc319fbi.2
UCSC ID: ENST00000408888.8_7
RefSeq Accession: NM_015014.4
Protein: P42696 (aka RBM34_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.