ID:SSRA_HUMAN DESCRIPTION: RecName: Full=Translocon-associated protein subunit alpha; Short=TRAP-alpha; AltName: Full=Signal sequence receptor subunit alpha; Short=SSR-alpha; Flags: Precursor; FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. DOMAIN: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged. MISCELLANEOUS: Seems to bind calcium. SIMILARITY: Belongs to the TRAP-alpha family. SEQUENCE CAUTION: Sequence=CAI16444.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03896 - Translocon-associated protein (TRAP), alpha subunit
ModBase Predicted Comparative 3D Structure on P43307
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006613 cotranslational protein targeting to membrane GO:0008284 positive regulation of cell proliferation GO:0036498 IRE1-mediated unfolded protein response
AJ420492 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1601244. AK026687 - Homo sapiens cDNA: FLJ23034 fis, clone LNG02018. AK024294 - Homo sapiens cDNA FLJ14232 fis, clone NT2RP4000035. JD357931 - Sequence 338955 from Patent EP1572962. JD244659 - Sequence 225683 from Patent EP1572962. JD047614 - Sequence 28638 from Patent EP1572962. JD047615 - Sequence 28639 from Patent EP1572962. JD238370 - Sequence 219394 from Patent EP1572962. JD238371 - Sequence 219395 from Patent EP1572962. JD426859 - Sequence 407883 from Patent EP1572962. JD135795 - Sequence 116819 from Patent EP1572962. JD052727 - Sequence 33751 from Patent EP1572962. AK025753 - Homo sapiens cDNA: FLJ22100 fis, clone HEP17127. JD134356 - Sequence 115380 from Patent EP1572962. JD070588 - Sequence 51612 from Patent EP1572962. JD150902 - Sequence 131926 from Patent EP1572962. JD376595 - Sequence 357619 from Patent EP1572962. JD463186 - Sequence 444210 from Patent EP1572962. JD213224 - Sequence 194248 from Patent EP1572962. JD542965 - Sequence 523989 from Patent EP1572962. JD560981 - Sequence 542005 from Patent EP1572962. JD165271 - Sequence 146295 from Patent EP1572962. JD213223 - Sequence 194247 from Patent EP1572962. CR936719 - Homo sapiens mRNA; cDNA DKFZp781N23103 (from clone DKFZp781N23103). AK075562 - Homo sapiens cDNA PSEC0262 fis, clone NT2RP3004505, highly similar to TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT PRECURSOR. AF156965 - Homo sapiens translocon-associated protein alpha subunit mRNA, complete cds. JD250673 - Sequence 231697 from Patent EP1572962. JD288826 - Sequence 269850 from Patent EP1572962. JD168854 - Sequence 149878 from Patent EP1572962. JD492534 - Sequence 473558 from Patent EP1572962. JD280192 - Sequence 261216 from Patent EP1572962. JD374774 - Sequence 355798 from Patent EP1572962. JD393905 - Sequence 374929 from Patent EP1572962. JD299848 - Sequence 280872 from Patent EP1572962. JD420450 - Sequence 401474 from Patent EP1572962. JD237513 - Sequence 218537 from Patent EP1572962. JD219882 - Sequence 200906 from Patent EP1572962. JD237675 - Sequence 218699 from Patent EP1572962. JD261848 - Sequence 242872 from Patent EP1572962. JD552517 - Sequence 533541 from Patent EP1572962. JD168539 - Sequence 149563 from Patent EP1572962. JD044715 - Sequence 25739 from Patent EP1572962. JD289449 - Sequence 270473 from Patent EP1572962. AK291550 - Homo sapiens cDNA FLJ78242 complete cds, highly similar to Homo sapiens signal sequence receptor, alpha (translocon-associated protein alpha), mRNA. JD296137 - Sequence 277161 from Patent EP1572962. BC007710 - Homo sapiens signal sequence receptor, alpha, mRNA (cDNA clone MGC:10331 IMAGE:4054116), complete cds. AK222762 - Homo sapiens mRNA for signal sequence receptor, alpha variant, clone: HEP00909. AK222809 - Homo sapiens mRNA for signal sequence receptor, alpha variant, clone: HEP04334. JD524202 - Sequence 505226 from Patent EP1572962. JD198875 - Sequence 179899 from Patent EP1572962. JD243543 - Sequence 224567 from Patent EP1572962. Z12830 - H.sapiens mRNA for SSR alpha subunit. CR456961 - Homo sapiens full open reading frame cDNA clone RZPDo834B0119D for gene SSR1, signal sequence receptor, alpha (translocon-associated protein alpha); complete cds, incl. stopcodon. KJ892203 - Synthetic construct Homo sapiens clone ccsbBroadEn_01597 SSR1 gene, encodes complete protein. AK312653 - Homo sapiens cDNA, FLJ93042, highly similar to Homo sapiens signal sequence receptor, alpha (translocon-associated protein alpha) (SSR1), mRNA. BT007387 - Homo sapiens signal sequence receptor, alpha (translocon-associated protein alpha) mRNA, complete cds. DQ892751 - Synthetic construct clone IMAGE:100005381; FLH189361.01X; RZPDo839E0474D signal sequence receptor, alpha (translocon-associated protein alpha) (SSR1) gene, encodes complete protein. EU176743 - Synthetic construct Homo sapiens clone IMAGE:100011511; FLH189360.01L; RZPDo839H10255D signal sequence receptor, alpha (translocon-associated protein alpha) (SSR1) gene, encodes complete protein. AB464204 - Synthetic construct DNA, clone: pF1KB6326, Homo sapiens SSR1 gene for signal sequence receptor alpha, without stop codon, in Flexi system. JD308736 - Sequence 289760 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P43307 (Reactome details) participates in the following event(s):
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-381070 IRE1alpha activates chaperones R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-381119 Unfolded Protein Response (UPR) R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
