ID:TLR2_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 2; AltName: Full=Toll/interleukin-1 receptor-like protein 4; AltName: CD_antigen=CD282; Flags: Precursor; FUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. SUBUNIT: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3 (By similarity). INTERACTION: C3PTT6:PAUF; NbExp=3; IntAct=EBI-973722, EBI-3505892; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. PTM: Glycosylation of Asn-442 is critical for secretion of the N- terminal ectodomain of TLR2. POLYMORPHISM: Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 14 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60603
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JB406675 - Sequence 1 from Patent WO2012072685. AF424050 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, 5' untranslated region, splice variant E. AF424053 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, 5' untranslated region, splice variant C. AF424049 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, 5' untranslated region, splice variant B. AF424051 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, 5' untranslated region, splice variant A. AF424052 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, 5' untranslated region, splice variant D. HW061240 - JP 2012529430-A/115: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. HW534930 - JP 2014508161-A/1: COMPOSITIONS AND METHODS FOR TREATING LUNG DISEASE AND INJURY. JA394582 - Sequence 4 from Patent WO2011066475. JB181736 - Sequence 1 from Patent WO2012118911. JB202420 - Sequence 1 from Patent WO2012118910. JB252048 - Sequence 115 from Patent EP2440214. LP764947 - Sequence 115 from Patent EP3276004. LP895491 - Sequence 355 from Patent EP3253886. BC033756 - Homo sapiens toll-like receptor 2, mRNA (cDNA clone MGC:45301 IMAGE:5213439), complete cds. AF051152 - Homo sapiens Toll/interleukin-1 receptor-like protein 4 (TIL4) mRNA, complete cds. JD452857 - Sequence 433881 from Patent EP1572962. AX429250 - Sequence 5 from Patent WO0235236. U88878 - Homo sapiens Toll-like receptor 2 (TLR2) mRNA, complete cds. JD136858 - Sequence 117882 from Patent EP1572962. AK125659 - Homo sapiens cDNA FLJ43671 fis, clone SYNOV4007553, highly similar to Toll-like receptor 2 precursor. JD283164 - Sequence 264188 from Patent EP1572962. CU689724 - Synthetic construct Homo sapiens gateway clone IMAGE:100020083 5' read TLR2 mRNA. AF502291 - Homo sapiens toll-like receptor 2 mRNA, partial cds. AB590438 - Synthetic construct DNA, clone: pFN21AE1434, Homo sapiens TLR2 gene for toll-like receptor 2, without stop codon, in Flexi system. KU178364 - Homo sapiens toll-like receptor 2 isoform 1 (TLR2) mRNA, partial cds. KU178365 - Homo sapiens toll-like receptor 2 isoform 2 (TLR2) mRNA, partial cds, alternatively spliced. DQ894005 - Synthetic construct Homo sapiens clone IMAGE:100008465; FLH166452.01L; RZPDo839H0185D toll-like receptor 2 (TLR2) gene, encodes complete protein. KJ897680 - Synthetic construct Homo sapiens clone ccsbBroadEn_07074 TLR2 gene, encodes complete protein. KR710859 - Synthetic construct Homo sapiens clone CCSBHm_00017694 TLR2 (TLR2) mRNA, encodes complete protein. KR710860 - Synthetic construct Homo sapiens clone CCSBHm_00017696 TLR2 (TLR2) mRNA, encodes complete protein. KR710861 - Synthetic construct Homo sapiens clone CCSBHm_00017697 TLR2 (TLR2) mRNA, encodes complete protein. KR710862 - Synthetic construct Homo sapiens clone CCSBHm_00017699 TLR2 (TLR2) mRNA, encodes complete protein. AB445624 - Homo sapiens TLR2 mRNA for toll-like receptor 2, complete cds. DQ012265 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-1 allele, complete cds. DQ012266 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-2 allele, complete cds. DQ012267 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-3 allele, complete cds. DQ012268 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-4 allele, complete cds. DQ012269 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-5 allele, complete cds. DQ012270 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-6 allele, complete cds. DQ012271 - Homo sapiens toll-like receptor 2 (TLR2) mRNA, TLR2-7 allele, complete cds. EU176198 - Synthetic construct Homo sapiens clone IMAGE:100006347; FLH166459.01X; RZPDo839E04250D toll-like receptor 2 (TLR2) gene, encodes complete protein. JD130946 - Sequence 111970 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60603 (Reactome details) participates in the following event(s):
R-HSA-168951 TLR1:TLR2 is recruited to ligand:CD14 R-HSA-1974676 Beta defensin 103 activates TLR1:TLR2 R-HSA-5432814 SFTPA/SFTPD binds TLR2:TLR1 R-HSA-168950 TLR6:TLR2 is recruited to ligand:CD14:CD36 R-HSA-6798743 Exocytosis of secretory granule membrane proteins R-HSA-2201316 Activated TLR2/4 interacts with MAL(TIRAP) R-HSA-166072 MyD88 forms a complex with MAL:activated TLR2/4 R-HSA-2201322 MAL is phosphorylated by BTK R-HSA-2559414 Activated TLR2/4:MAL interacts with BTK R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:Mal:MyD88 R-HSA-166082 IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-166286 Multiple IRAK1 autophosphorylation steps R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166363 TRAF6 binds to hp- IRAK1 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex R-HSA-2262777 TRAF6 binds to p-IRAK2 R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-1461957 Beta defensins R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-6798695 Neutrophil degranulation R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-1461973 Defensins R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168249 Innate Immune System R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-6803157 Antimicrobial peptides R-HSA-168256 Immune System R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-5260271 Diseases of Immune System R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
