Human Gene TMEM51 (ENST00000376008.3_4) from GENCODE V47lift37
  Description: transmembrane protein 51, transcript variant 3 (from RefSeq NM_001136218.2)
Gencode Transcript: ENST00000376008.3_4
Gencode Gene: ENSG00000171729.14_11
Transcript (Including UTRs)
   Position: hg19 chr1:15,480,243-15,546,974 Size: 66,732 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:15,541,584-15,546,239 Size: 4,656 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:15,480,243-15,546,974)mRNA (may differ from genome)Protein (253 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM51_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 51;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.65 RPKM in Kidney - Cortex
Total median expression: 313.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -180.10474-0.380 Picture PostScript Text
3' UTR -225.50735-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15345 - Transmembrane protein 51

ModBase Predicted Comparative 3D Structure on Q9NW97
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK292184 - Homo sapiens cDNA FLJ78288 complete cds, highly similar to Homo sapiens transmembrane protein 51 (TMEM51), mRNA.
AK129922 - Homo sapiens cDNA FLJ26412 fis, clone KDN00112.
AK001061 - Homo sapiens cDNA FLJ10199 fis, clone HEMBA1004850.
BC000593 - Homo sapiens transmembrane protein 51, mRNA (cDNA clone MGC:3086 IMAGE:3347548), complete cds.
JD406916 - Sequence 387940 from Patent EP1572962.
BC005177 - Homo sapiens transmembrane protein 51, mRNA (cDNA clone MGC:990 IMAGE:3507275), complete cds.
AK098467 - Homo sapiens cDNA FLJ25601 fis, clone JTH13829.
JD192485 - Sequence 173509 from Patent EP1572962.
JD128431 - Sequence 109455 from Patent EP1572962.
JD141247 - Sequence 122271 from Patent EP1572962.
BC000202 - Homo sapiens transmembrane protein 51, mRNA (cDNA clone MGC:3114 IMAGE:3351196), complete cds.
JF432888 - Synthetic construct Homo sapiens clone IMAGE:100074212 transmembrane protein 51 (TMEM51) gene, encodes complete protein.
KJ902761 - Synthetic construct Homo sapiens clone ccsbBroadEn_12155 TMEM51 gene, encodes complete protein.
KJ894126 - Synthetic construct Homo sapiens clone ccsbBroadEn_03520 TMEM51 gene, encodes complete protein.
KJ899074 - Synthetic construct Homo sapiens clone ccsbBroadEn_08468 TMEM51 gene, encodes complete protein.
CR457120 - Homo sapiens full open reading frame cDNA clone RZPDo834A109D for gene FLJ10199, hypothetical protein FLJ10199; complete cds, incl. stopcodon.
JD442521 - Sequence 423545 from Patent EP1572962.
JD088186 - Sequence 69210 from Patent EP1572962.
JD189207 - Sequence 170231 from Patent EP1572962.
JD189208 - Sequence 170232 from Patent EP1572962.
JD115187 - Sequence 96211 from Patent EP1572962.
JD562201 - Sequence 543225 from Patent EP1572962.
JD550386 - Sequence 531410 from Patent EP1572962.
JD114703 - Sequence 95727 from Patent EP1572962.
JD470313 - Sequence 451337 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K819, C1orf72, ENST00000376008.1, ENST00000376008.2, NM_001136218, Q9NW97, TMM51_HUMAN, uc318mqz.1, uc318mqz.2
UCSC ID: ENST00000376008.3_4
RefSeq Accession: NM_001136218.2
Protein: Q9NW97 (aka TMM51_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.