ID:UN5CL_HUMAN DESCRIPTION: RecName: Full=UNC5C-like protein; AltName: Full=Protein unc-5 homolog C-like; AltName: Full=ZU5 and death domain-containing protein; FUNCTION: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets. SUBUNIT: Interacts with p65/RELA and NFKB1. SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein (Potential). Cytoplasm. TISSUE SPECIFICITY: Expressed in pancreas, liver and kidney. SIMILARITY: Belongs to the unc-5 family. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 1 ZU5 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IV45
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.