Human Gene UNC5CL (ENST00000244565.8_8) from GENCODE V47lift37
  Description: unc-5 family C-terminal like (from RefSeq NM_173561.3)
Gencode Transcript: ENST00000244565.8_8
Gencode Gene: ENSG00000124602.11_11
Transcript (Including UTRs)
   Position: hg19 chr6:40,994,634-41,006,960 Size: 12,327 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr6:40,996,112-41,002,813 Size: 6,702 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:40,994,634-41,006,960)mRNA (may differ from genome)Protein (518 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UN5CL_HUMAN
DESCRIPTION: RecName: Full=UNC5C-like protein; AltName: Full=Protein unc-5 homolog C-like; AltName: Full=ZU5 and death domain-containing protein;
FUNCTION: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets.
SUBUNIT: Interacts with p65/RELA and NFKB1.
SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein (Potential). Cytoplasm.
TISSUE SPECIFICITY: Expressed in pancreas, liver and kidney.
SIMILARITY: Belongs to the unc-5 family.
SIMILARITY: Contains 1 death domain.
SIMILARITY: Contains 1 ZU5 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.65 RPKM in Kidney - Cortex
Total median expression: 159.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -39.60121-0.327 Picture PostScript Text
3' UTR -566.301478-0.383 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000488 - Death
IPR011029 - DEATH-like
IPR000906 - ZU5

Pfam Domains:
PF00531 - Death domain
PF00791 - ZU5 domain
PF17217 - UPA domain

SCOP Domains:
47986 - DEATH domain

ModBase Predicted Comparative 3D Structure on Q8IV45
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005042 netrin receptor activity
GO:0008233 peptidase activity

Biological Process:
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0038007 netrin-activated signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046330 positive regulation of JNK cascade

Cellular Component:
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK310594 - Homo sapiens cDNA, FLJ17636.
JF681947 - Homo sapiens cell-line CaCo-2 MUXA protein (MUXA) mRNA, complete cds.
BC035284 - Homo sapiens unc-5 homolog C (C. elegans)-like, mRNA (cDNA clone MGC:34763 IMAGE:5189247), complete cds.
JD438598 - Sequence 419622 from Patent EP1572962.
JD304315 - Sequence 285339 from Patent EP1572962.
JD133597 - Sequence 114621 from Patent EP1572962.
JD259750 - Sequence 240774 from Patent EP1572962.
JD261001 - Sequence 242025 from Patent EP1572962.
JD290775 - Sequence 271799 from Patent EP1572962.
JD433614 - Sequence 414638 from Patent EP1572962.
JD252025 - Sequence 233049 from Patent EP1572962.
JD259458 - Sequence 240482 from Patent EP1572962.
JD259520 - Sequence 240544 from Patent EP1572962.
JD476426 - Sequence 457450 from Patent EP1572962.
JD422708 - Sequence 403732 from Patent EP1572962.
JD473991 - Sequence 455015 from Patent EP1572962.
JD486557 - Sequence 467581 from Patent EP1572962.
JD086013 - Sequence 67037 from Patent EP1572962.
JD336244 - Sequence 317268 from Patent EP1572962.
JD337010 - Sequence 318034 from Patent EP1572962.
JD176185 - Sequence 157209 from Patent EP1572962.
JD255529 - Sequence 236553 from Patent EP1572962.
JD398934 - Sequence 379958 from Patent EP1572962.
JD253573 - Sequence 234597 from Patent EP1572962.
JD140242 - Sequence 121266 from Patent EP1572962.
JD370416 - Sequence 351440 from Patent EP1572962.
JD143252 - Sequence 124276 from Patent EP1572962.
JD098203 - Sequence 79227 from Patent EP1572962.
JD130407 - Sequence 111431 from Patent EP1572962.
JD453319 - Sequence 434343 from Patent EP1572962.
AY510109 - Homo sapiens ZU5 and death domain-containing inhibitor of NF-kB mRNA, complete cds.
KJ900489 - Synthetic construct Homo sapiens clone ccsbBroadEn_09883 UNC5CL gene, encodes complete protein.
AB527659 - Synthetic construct DNA, clone: pF1KB0479, Homo sapiens UNC5CL gene for unc-5 homolog C (C. elegans)-like, without stop codon, in Flexi system.
JD447437 - Sequence 428461 from Patent EP1572962.
JD202274 - Sequence 183298 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000244565.1, ENST00000244565.2, ENST00000244565.3, ENST00000244565.4, ENST00000244565.5, ENST00000244565.6, ENST00000244565.7, NM_173561, Q5TGU1, Q8IV45, uc317epb.1, uc317epb.2, UN5CL_HUMAN, ZUD
UCSC ID: ENST00000244565.8_8
RefSeq Accession: NM_173561.3
Protein: Q8IV45 (aka UN5CL_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.