Human Gene WDR73 (ENST00000434634.7_7) from GENCODE V47lift37
  Description: WD repeat domain 73, transcript variant 5 (from RefSeq NR_130947.2)
Gencode Transcript: ENST00000434634.7_7
Gencode Gene: ENSG00000177082.13_11
Transcript (Including UTRs)
   Position: hg19 chr15:85,182,516-85,197,514 Size: 14,999 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr15:85,186,701-85,197,505 Size: 10,805 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:85,182,516-85,197,514)mRNA (may differ from genome)Protein (378 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: WDR73_HUMAN
DESCRIPTION: RecName: Full=WD repeat-containing protein 73;
SIMILARITY: Belongs to the WD repeat WDR73 family.
SIMILARITY: Contains 3 WD repeats.
SEQUENCE CAUTION: Sequence=AAF28942.1; Type=Frameshift; Positions=374;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: WDR73
Diseases sorted by gene-association score: galloway-mowat syndrome* (1400), moved to 251300* (350), autosomal recessive disease (6), nephrotic syndrome (5), microcephaly (3), intellectual disability (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.58 RPKM in Pituitary
Total median expression: 467.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -1669.204185-0.399 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR017986 - WD40_repeat_dom

SCOP Domains:
50952 - Soluble quinoprotein glucose dehydrogenase
50960 - TolB, C-terminal domain
63829 - Calcium-dependent phosphotriesterase
69304 - Tricorn protease N-terminal domain
101898 - NHL repeat
50965 - Galactose oxidase, central domain
75011 - 3-carboxy-cis,cis-mucoante lactonizing enzyme
101908 - Putative isomerase YbhE
117289 - Nucleoporin domain
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50974 - Nitrous oxide reductase, N-terminal domain
50978 - WD40 repeat-like
50993 - Peptidase/esterase 'gauge' domain
69322 - Tricorn protease domain 2
50998 - Quinoprotein alcohol dehydrogenase-like
51004 - C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
82171 - DPP6 N-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q6P4I2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0006997 nucleus organization
GO:0031122 cytoplasmic microtubule organization
GO:0043066 negative regulation of apoptotic process

Cellular Component:
GO:0000922 spindle pole
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0032154 cleavage furrow


-  Descriptions from all associated GenBank mRNAs
  BC020252 - Homo sapiens WD repeat domain 73, mRNA (cDNA clone IMAGE:4858895).
BC014115 - Homo sapiens WD repeat domain 73, mRNA (cDNA clone IMAGE:4547992), partial cds.
AK225068 - Homo sapiens mRNA for hypothetical protein FLJ14888 variant, clone: CAE01185.
AK027794 - Homo sapiens cDNA FLJ14888 fis, clone PLACE1003762.
AK225199 - Homo sapiens mRNA for hypothetical protein FLJ14888 variant, clone: COL04241.
AK055729 - Homo sapiens cDNA FLJ31167 fis, clone KIDNE1000145, highly similar to Homo sapiens WD repeat domain 73 (WDR73), mRNA.
BC050648 - Homo sapiens WD repeat domain 73, mRNA (cDNA clone IMAGE:5172358), partial cds.
AF161382 - Homo sapiens HSPC264 mRNA, partial cds.
AK055578 - Homo sapiens cDNA FLJ31016 fis, clone HLUNG2000314.
BC063392 - Homo sapiens WD repeat domain 73, mRNA (cDNA clone MGC:70660 IMAGE:5168550), complete cds.
AK090406 - Homo sapiens mRNA for FLJ00296 protein.
AK295372 - Homo sapiens cDNA FLJ57727 complete cds, highly similar to Homo sapiens WD repeat domain 73 (WDR73), mRNA.
AL357213 - Homo sapiens EST from clone 711518, full insert.
DQ581370 - Homo sapiens piRNA piR-49482, complete sequence.
JD319625 - Sequence 300649 from Patent EP1572962.
JD365030 - Sequence 346054 from Patent EP1572962.
JD070909 - Sequence 51933 from Patent EP1572962.
JD105435 - Sequence 86459 from Patent EP1572962.
JD070912 - Sequence 51936 from Patent EP1572962.
JD514223 - Sequence 495247 from Patent EP1572962.
JD492097 - Sequence 473121 from Patent EP1572962.
JD153081 - Sequence 134105 from Patent EP1572962.
JD140580 - Sequence 121604 from Patent EP1572962.
JD198369 - Sequence 179393 from Patent EP1572962.
JD272021 - Sequence 253045 from Patent EP1572962.
JD431855 - Sequence 412879 from Patent EP1572962.
JD281493 - Sequence 262517 from Patent EP1572962.
JD160934 - Sequence 141958 from Patent EP1572962.
JD517469 - Sequence 498493 from Patent EP1572962.
JD420993 - Sequence 402017 from Patent EP1572962.
JD420994 - Sequence 402018 from Patent EP1572962.
JD558272 - Sequence 539296 from Patent EP1572962.
JD117087 - Sequence 98111 from Patent EP1572962.
JD291502 - Sequence 272526 from Patent EP1572962.
JD092556 - Sequence 73580 from Patent EP1572962.
JD544612 - Sequence 525636 from Patent EP1572962.
JD101730 - Sequence 82754 from Patent EP1572962.
JD249822 - Sequence 230846 from Patent EP1572962.
JD148291 - Sequence 129315 from Patent EP1572962.
JD463804 - Sequence 444828 from Patent EP1572962.
JD350308 - Sequence 331332 from Patent EP1572962.
JD040156 - Sequence 21180 from Patent EP1572962.
AK027200 - Homo sapiens cDNA: FLJ23547 fis, clone LNG08437, highly similar to AF161382 Homo sapiens HSPC264 mRNA.
DQ598628 - Homo sapiens piRNA piR-36694, complete sequence.
JD320056 - Sequence 301080 from Patent EP1572962.
JD112622 - Sequence 93646 from Patent EP1572962.
DQ581890 - Homo sapiens piRNA piR-50002, complete sequence.
DQ594483 - Homo sapiens piRNA piR-60595, complete sequence.
DQ581779 - Homo sapiens piRNA piR-49891, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000434634.1, ENST00000434634.2, ENST00000434634.3, ENST00000434634.4, ENST00000434634.5, ENST00000434634.6, HSPC264, NR_130947, Q6P4I2, Q96JZ1, Q9P0B7, uc320ddg.1, uc320ddg.2, WDR73_HUMAN
UCSC ID: ENST00000434634.7_7
RefSeq Accession: NM_032856.5
Protein: Q6P4I2 (aka WDR73_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene WDR73:
ataxias (Hereditary Ataxia Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.