Human Gene ZNF317 (ENST00000247956.11_6) from GENCODE V47lift37
  Description: zinc finger protein 317, transcript variant 1 (from RefSeq NM_020933.5)
Gencode Transcript: ENST00000247956.11_6
Gencode Gene: ENSG00000130803.15_12
Transcript (Including UTRs)
   Position: hg19 chr19:9,251,073-9,274,089 Size: 23,017 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr19:9,266,693-9,272,109 Size: 5,417 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:9,251,073-9,274,089)mRNA (may differ from genome)Protein (595 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN317_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 317;
FUNCTION: May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed. Isoform 3 and isoform 4 are expressed only in lymphocytes, spleen and lung.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAB13414.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.92 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 363.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.10288-0.348 Picture PostScript Text
3' UTR -563.601980-0.285 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
109640 - KRAB domain (Kruppel-associated box)
56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
57667 - beta-beta-alpha zinc fingers
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57783 - Zinc beta-ribbon
57802 - Rubredoxin-like
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger
161219 - CHY zinc finger-like

ModBase Predicted Comparative 3D Structure on Q96PQ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK314560 - Homo sapiens cDNA, FLJ95384, highly similar to Homo sapiens zinc finger protein 317 (ZNF317), mRNA.
AF148135 - Homo sapiens ZNF317-1 protein (ZNF317) mRNA, complete cds.
AF275255 - Homo sapiens ZNF317-2 protein (ZNF317) mRNA, complete cds.
AK056570 - Homo sapiens cDNA FLJ32008 fis, clone NT2RP7009482, highly similar to Zinc finger protein 317.
BC078154 - Homo sapiens zinc finger protein 317, mRNA (cDNA clone MGC:90227 IMAGE:6060418), complete cds.
BC009367 - Homo sapiens zinc finger protein 317, mRNA (cDNA clone IMAGE:4110510), partial cds.
AL834126 - Homo sapiens mRNA; cDNA DKFZp451B042 (from clone DKFZp451B042).
AK304871 - Homo sapiens cDNA FLJ58239 complete cds, highly similar to Zinc finger protein 317.
AK304151 - Homo sapiens cDNA FLJ57774 complete cds, moderately similar to Zinc finger protein 317.
JD446040 - Sequence 427064 from Patent EP1572962.
JD428520 - Sequence 409544 from Patent EP1572962.
JD354102 - Sequence 335126 from Patent EP1572962.
AB046808 - Homo sapiens KIAA1588 mRNA for KIAA1588 protein.
JD135473 - Sequence 116497 from Patent EP1572962.
JD074333 - Sequence 55357 from Patent EP1572962.
AF307097 - Homo sapiens ZNF317-4 protein mRNA, complete cds, alternatively spliced.
AF307096 - Homo sapiens ZNF317-3 protein mRNA, complete cds, alternatively spliced.
CU687320 - Synthetic construct Homo sapiens gateway clone IMAGE:100023017 5' read ZNF317 mRNA.
AB590108 - Synthetic construct DNA, clone: pFN21AA1588, Homo sapiens ZNF317 gene for zinc finger protein 317, without stop codon, in Flexi system.
EU446838 - Synthetic construct Homo sapiens clone IMAGE:100070008; IMAGE:100012047; FLH257158.01L zinc finger protein 317 (ZNF317) gene, encodes complete protein.
KJ894448 - Synthetic construct Homo sapiens clone ccsbBroadEn_03842 ZNF317 gene, encodes complete protein.
KJ902996 - Synthetic construct Homo sapiens clone ccsbBroadEn_12390 ZNF317 gene, encodes complete protein.
AK056205 - Homo sapiens cDNA FLJ31643 fis, clone NT2RI2003741, moderately similar to ZINC FINGER PROTEIN 135.
BC001685 - Homo sapiens cDNA clone IMAGE:3009713, with apparent retained intron.
JD196651 - Sequence 177675 from Patent EP1572962.
JD057283 - Sequence 38307 from Patent EP1572962.
JD450921 - Sequence 431945 from Patent EP1572962.
JD080409 - Sequence 61433 from Patent EP1572962.
JD165662 - Sequence 146686 from Patent EP1572962.
JD272600 - Sequence 253624 from Patent EP1572962.
JD453844 - Sequence 434868 from Patent EP1572962.
JD493074 - Sequence 474098 from Patent EP1572962.
JD530888 - Sequence 511912 from Patent EP1572962.
DQ586482 - Homo sapiens piRNA piR-53594, complete sequence.
JD171399 - Sequence 152423 from Patent EP1572962.
JD204075 - Sequence 185099 from Patent EP1572962.
JD052615 - Sequence 33639 from Patent EP1572962.
JD381912 - Sequence 362936 from Patent EP1572962.
JD537733 - Sequence 518757 from Patent EP1572962.
JD510268 - Sequence 491292 from Patent EP1572962.
JD285610 - Sequence 266634 from Patent EP1572962.
JD501490 - Sequence 482514 from Patent EP1572962.
JD261814 - Sequence 242838 from Patent EP1572962.
JD431493 - Sequence 412517 from Patent EP1572962.
JD090190 - Sequence 71214 from Patent EP1572962.
JD412952 - Sequence 393976 from Patent EP1572962.
JD559749 - Sequence 540773 from Patent EP1572962.
JD044170 - Sequence 25194 from Patent EP1572962.
JD439860 - Sequence 420884 from Patent EP1572962.
JD497410 - Sequence 478434 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96PQ6 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000247956.1, ENST00000247956.10, ENST00000247956.2, ENST00000247956.3, ENST00000247956.4, ENST00000247956.5, ENST00000247956.6, ENST00000247956.7, ENST00000247956.8, ENST00000247956.9, KIAA1588, NM_020933, Q6DCA9, Q96PM0, Q96PM1, Q96PQ6, Q96PT2, Q9HCI4, uc317ewh.1, uc317ewh.2, ZN317_HUMAN
UCSC ID: ENST00000247956.11_6
RefSeq Accession: NM_020933.5
Protein: Q96PQ6 (aka ZN317_HUMAN or Z317_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.