Human Gene ZNF687 (ENST00000336715.11_5) from GENCODE V47lift37
  Description: zinc finger protein 687, transcript variant 2 (from RefSeq NM_020832.3)
Gencode Transcript: ENST00000336715.11_5
Gencode Gene: ENSG00000143373.18_13
Transcript (Including UTRs)
   Position: hg19 chr1:151,254,775-151,264,652 Size: 9,878 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:151,258,768-151,263,685 Size: 4,918 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:151,254,775-151,264,652)mRNA (may differ from genome)Protein (1237 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN687_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 687;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 10 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAA92679.1; Type=Erroneous initiation; Sequence=BAB14406.1; Type=Erroneous initiation; Sequence=CAH18162.1; Type=Frameshift; Positions=1062;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF687
Diseases sorted by gene-association score: paget disease of bone 6* (1341), paget's disease of bone* (91), giant cell tumor (34)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.51 RPKM in Testis
Total median expression: 308.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.50114-0.522 Picture PostScript Text
3' UTR -337.30967-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF16622 - zinc-finger C2H2-type

SCOP Domains:
48695 - Multiheme cytochromes
55060 - GHMP Kinase, C-terminal domain
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q8N1G0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  CR749307 - Homo sapiens mRNA; cDNA DKFZp781I1719 (from clone DKFZp781I1719).
DQ655935 - Homo sapiens clone UGL1d08, mRNA sequence.
AB037862 - Homo sapiens KIAA1441 mRNA for KIAA1441 protein.
BC032463 - Homo sapiens zinc finger protein 687, mRNA (cDNA clone MGC:40365 IMAGE:5196247), complete cds.
AB384211 - Synthetic construct DNA, clone: pF1KSDA1441, Homo sapiens ZNF687 gene for zinc finger protein 687, complete cds, without stop codon, in Flexi system.
JF432733 - Synthetic construct Homo sapiens clone IMAGE:100073976 zinc finger protein 687 (ZNF687) gene, encodes complete protein.
DQ585200 - Homo sapiens piRNA piR-52312, complete sequence.
DQ579639 - Homo sapiens piRNA piR-47751, complete sequence.
AK023105 - Homo sapiens cDNA FLJ13043 fis, clone NT2RP3001338, weakly similar to ZINC FINGER PROTEIN 81.
BC020245 - Homo sapiens zinc finger protein 687, mRNA (cDNA clone IMAGE:4130650), with apparent retained intron.
JD215364 - Sequence 196388 from Patent EP1572962.
JD490433 - Sequence 471457 from Patent EP1572962.
JD501389 - Sequence 482413 from Patent EP1572962.
JD047043 - Sequence 28067 from Patent EP1572962.
JD508841 - Sequence 489865 from Patent EP1572962.
JD348023 - Sequence 329047 from Patent EP1572962.
JD539836 - Sequence 520860 from Patent EP1572962.
JD535016 - Sequence 516040 from Patent EP1572962.
JD217191 - Sequence 198215 from Patent EP1572962.
JD481091 - Sequence 462115 from Patent EP1572962.
JD355341 - Sequence 336365 from Patent EP1572962.
JD146180 - Sequence 127204 from Patent EP1572962.
JD459072 - Sequence 440096 from Patent EP1572962.
JD343436 - Sequence 324460 from Patent EP1572962.
JD209084 - Sequence 190108 from Patent EP1572962.
DI486951 - KR 1020100056450-A/47: DSRNA FOR TREATING VIRAL INFECTION.
HV592926 - JP 2010532163-A/47: dsRNA for treating viral infection.
HW663578 - JP 2013212113-A/47: dsRNA for treating viral infection.
DI486911 - KR 1020100056450-A/7: DSRNA FOR TREATING VIRAL INFECTION.
DI486976 - KR 1020100056450-A/72: DSRNA FOR TREATING VIRAL INFECTION.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DV17, ENST00000336715.1, ENST00000336715.10, ENST00000336715.2, ENST00000336715.3, ENST00000336715.4, ENST00000336715.5, ENST00000336715.6, ENST00000336715.7, ENST00000336715.8, ENST00000336715.9, KIAA1441, NM_020832, Q68DQ8, Q8N1G0, Q9H937, Q9P2A7, uc317upa.1, uc317upa.2, ZN687_HUMAN
UCSC ID: ENST00000336715.11_5
RefSeq Accession: NM_020832.3
Protein: Q8N1G0 (aka ZN687_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.