Gene interactions and pathways from curated databases and text-mining
EMBO Rep 2010, PMID: 20508642

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

Krebs, Arnaud R; Demmers, Jeroen; Karmodiya, Krishanpal; Chang, Nan-Chi; Chang, Alice Chien; Tora, László

The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.

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Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: CCDC101 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — LUC7L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EIF3C — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — DHX15 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: WDR5 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SNRPA — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DDX5 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SRSF4 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: POLR2B — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ZZZ3 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED31 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ACTC1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED15 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MARK2 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED27 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — RBM39 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — EIF3L (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED28 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRPF6 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRA2A — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED4 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SNW1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRRC2B — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED17 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: WDTC1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CCDC101 — TRRAP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — ILF3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MYEF2 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED29 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — DDX17 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — DDX3X (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — HNRNPF (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: EIF3B — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — KAT2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SRRM2 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ILF2 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PLRG1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KAT2A — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — KRT8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — RNPS1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — NONO (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED26 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — HELT (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED23 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — SRRM1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED20 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — LRCH4 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — CDK8 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — LUZP1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDC5L — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED22 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED13 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SSB — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — DDB1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — EIF3M (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — EIF3H (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: AKAP8 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: POLR2C — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — DHX16 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SFPQ — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MARK3 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: XAB2 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HDAC1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: KAT2A — TRRAP (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED30 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: NCBP1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — PUF60 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: DOCK6 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED12 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED25 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRIM28 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED6 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED14 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: SRSF3 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: RALY — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — PSPC1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — SRSF5 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — EIF3I (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — RBM14 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — SRSF1 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: PRPF19 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — SIN3A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — HNRNPM (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED18 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: HSPA5 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: MED1 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — POLR2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: LUC7L3 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: CDC40 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: ERCC4 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: C11orf30 — TADA2A (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — RNF41 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — HNRNPC (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TADA2A — MED16 (physical association, affinity chromatography technology)
  • IRef Biogrid Interaction: TRA2B — TADA2A (physical association, affinity chromatography technology)
  • IRef Intact Interaction: Complex of KAT2A-TADA2A-MED1 (association, anti bait coimmunoprecipitation)
In total, 96 gene pairs are associated to this article in curated databases