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CASP1 — PTGS2

Text-mined interactions from Literome

Yrjänheikki et al., Proc Natl Acad Sci U S A 1999 (Brain Ischemia...) : The treatment inhibits morphological activation of microglia in the area adjacent to the infarction, inhibits induction of IL-1beta converting enzyme , and reduces cyclooxygenase-2 expression and prostaglandin E ( 2 ) production
Pelletier et al., J Rheumatol 2001 (Osteoarthritis) : Specific inhibition of either COX-2 or iNOS reduced the level of chondrocyte death and caspase 3
Dandekar et al., Clin Cancer Res 2004 (Neoplasms, Hormone-Dependent...) : Conditional suppression of COX-2 in PC-3ML caused reduced cell proliferation, decreased levels of phosphorylated AKT, G ( 0 ) -G ( 1 ) arrest, and increased apoptosis and caspase-3 activity
Zhang et al., Am J Hematol 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation , and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib
Laschke et al., Fertil Steril 2007 : Moreover, COX-2 inhibition suppressed cell proliferation and induced apoptosis associated caspase-3 expression
Liu et al., Ann Hematol 2007 (Leukemia) : Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro ... Taken together, our results demonstrate for the first time that downregulation of cyclooxygenase-2 expression, disruption of mitochondrial membrane potential, activation of caspase-3 , downregulation of Bcl-2, Bcl-Xl, and Mcl-1, and upregulation of Bax are involved in PPAR-gamma agonists induced apoptosis in these two human monocyte leukemia cells
John et al., Histol Histopathol 2007 (MAP Kinase Signaling System) : IL-18 lead to inhibition of collagen type II-deposition, decreased beta-integrin receptor and vinculin synthesis, SHC and MAPKinase activation, increased COX-2 synthesis and activation of caspase-3 in chondrocytes in a time- and dose dependent manner
Lim et al., Ann N Y Acad Sci 2007 (Carcinoma, Non-Small-Cell Lung...) : DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells ... Taken together, DMNQ S-64 may exhibit cytotoxicity against A549 cells via caspase activation and COX-2 inhibition
Yin et al., Food Chem Toxicol 2007 (Carcinoma, Hepatocellular...) : The brucine induced apoptosis was partially attributed to the activation of caspase 3 as well as cyclooxygenase 2 inhibition , since neither caspase 3 specific inhibitor, z-DEVD-fmk nor was exogenous addition of prostaglandin E ( 2 ) able to completely abrogate the brucine induced SMMC 7721 cell apoptosis
Wellmann et al., Pediatr Res 2010 : siRNA mediated RBM3 knockdown reduced cell viability and finally led to cell death, which did not involve caspase-3 mediated apoptosis, cell cycle arrest, or COX-2 regulation
Cunha et al., Molecular pain 2010 (Inflammation) : Because caspase-1 is involved in the induction of COX-2 expression and PGE2 production, our data support the assertion that caspase-1 is a key target to control inflammatory pain
Zhang et al., Int J Pharm 2013 (Stomach Neoplasms) : Moreover, UA-NPs led to more cell apoptosis through stronger inhibition of COX-2 and activation of caspase 3