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IL13 — MUC20

Text-mined interactions from Literome

Longphre et al., J Clin Invest 1999 (Asthma) : Furthermore, recombinant IL-9, but not IL-5 or IL-13 , stimulated mucin synthesis
Shim et al., Am J Physiol Lung Cell Mol Physiol 2001 (Metaplasia) : IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils ... Present results show that a cascade of EGFR involving neutrophils is implicated in interleukin (IL)-13 induced mucin expression in GC ... These findings indicate that EGFR signaling is involved in IL-13 induced mucin production
Zhu et al., Am J Respir Crit Care Med 2001 (Asthma...) : IL-13 caused mucous metaplasia, enhanced mucin gene expression, enhanced tissue hyaluronic acid accumulation, and subepithelial fibrosis
Kim et al., Acta Otolaryngol 2002 : This study aimed to investigate the direct effect of IL-13 on mucin gene expression and mucin secretion in cultured normal human nasal epithelial cells
Chu et al., Am J Pathol 2004 (Asthma) : IL-13 induced mucin expression may occur in part through TGF-beta2 up-regulation
Yoshisue et al., Biosci Biotechnol Biochem 2004 (Hyperplasia) : GM6001, a broad-spectrum inhibitor for MMP/ADAM, inhibited IL-13 induced mucin gene expression and mucus production as measured by periodic acid-Schiff staining
Zhen et al., Am J Respir Cell Mol Biol 2007 (Metaplasia) : However, there was constitutive release of TGF-alpha from normal human bronchial epithelial cells, and inhibition of TGF-alpha or EGFR reduced both constitutive and IL-13 induced mucin production
Lowry et al., Am J Respir Cell Mol Biol 2008 (Asthma...) : In contrast, IL-13 induced airway epithelial cell mucous cell hyperplasia, mucin and mucin related gene expression, epidermal growth factor receptor mRNA, and epidermal growth factor receptor activation along with airway hyperreactivity in WT mice but not in GGT ( enu1 ) mice
Hauber et al., Laryngoscope 2008 (Hypersensitivity...) : IL-4, IL-9, and IL-13 significantly increased epithelial mucin expression ( P < .05 ). Dexamethasone reduced Th2 type cytokine induced mucin expression in a dose dependent manner being statistically significant at concentrations > or=4.0 micromol/L ( IL-4 ) and > or=40.0 micromol/L ( IL-9 and IL-13 ) ( P < .05 ). ACC had no significant effect on IL-4 and IL-13 induced mucin expression, whereas IL-9 induced mucin expression was significantly decreased at concentrations > or=3.0 mmol/L ( P < .05 ). NFA and MSI-2216 decreased Th2 type cytokine induced mucin expression in a dose dependent manner. This effect was statistically significant at concentrations > or=100 micromol/L ( NFA ) and > or=50 micromol/L ( MSI-2216 ) ( P < .05 )
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Simon et al., Am J Respir Cell Mol Biol 2011 (Asthma...) : Up-regulation of MUC18 in airway epithelial cells by IL-13 : implications in bacterial adherence ... We investigated MUC18 regulation by IL-13 and the role of MUC18 in bacterial adherence to epithelial cells ... Human airway tissues, brushed bronchial epithelial cells from normal subjects and subjects with asthma, and epithelial cell lines ( e.g., HEK293 cells ) were used to study the regulation of MUC18 by IL-13 and the involvement of MUC18 in bacterial ( e.g., Mycoplasma pneumoniae [ Mp ] and nontypeable Haemophilus influenzae [ NTHi ] ) adherence to epithelial cells ... IL-13 increased MUC18 in cultured bronchial epithelial cells from normal subjects and particularly from subjects with asthma ... IL-13 induced MUC18 expression may be modulated in part through transcription factor specificity protein 1
Kasaian et al., Am J Respir Cell Mol Biol 2013 (Bronchial Hyperreactivity...) : In the ovalbumin induced lung inflammation model, the bifunctional IL-4/IL-13 antagonist reduced the IL-4 dependent rise in serum IgE titers, and reduced IL-13 dependent airway hyperresponsiveness, lung inflammation, mucin gene expression, and serum chitinase responses