◀ Back to TYR
AKT3 — TYR
Text-mined interactions from Literome
Bae et al., J Immunol 2003
:
Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met ( HRYLPM ) activated a broad spectrum of cellular signaling events, including an intracellular Ca ( 2+ ) concentration increase, phosphoinositide 3-kinase, extracellular signal regulated kinase, and Akt activation, however,
His-Glu-Tyr-Leu-Pro-Met ( HEYLPM )
activated only intracellular Ca ( 2+ ) concentration and
Akt but did not increase Ca ( 2+ )
Fu et al., J Cell Physiol 2006
(Prostatic Neoplasms) :
In DU145,
Tyr/Phe or Met restriction
reduces activity of
Akt , mitochondrial distribution of phosphorylated Raf and apoptosis inducing factor ( AIF ), and increases mitochondrial distribution of Bak
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation) :
Our results showed 1 ) activation of MUC1 induced recruitment of the PI3K regulatory subunit p85 to the MUC1 cytoplasmic tail ( CT ) as well as Akt phosphorylation, 2 ) MUC1 induced
Akt phosphorylation
required the presence of
Tyr ( 20 ) within the PI3K binding motif of the MUC1 CT, and 3 ) mutation of Tyr ( 20 ) or pharmacological inhibition of PI3K activation failed to block MUC1 induced suppression of TLR5 signaling
Nakashima et al., Hypertension 2008
(Hypertrophy) :
From these data, we conclude that not only PKC delta kinase activation but also the Src dependent
Tyr ( 311 ) phosphorylation
contributes to
Akt activation and subsequent VSMC hypertrophy induced by Ang II, thus signifying a novel molecular mechanism for enhancement of cardiovascular diseases induced by Ang II
Guillermet-Guibert et al., Proc Natl Acad Sci U S A 2008
:
In fibroblasts, which express p110beta but not p110gamma, p110beta mediated
Akt activation by the GPCR ligands stromal cell derived factor, sphingosine-1-phosphate, and lysophosphatidic acid but not by the
Tyr kinase ligands PDGF, insulin, and insulin-like growth factor 1
Tu et al., J Cell Physiol 2013
(Arthritis, Rheumatoid...) :
Transfection of dominant negative
Akt or application of PI3K inhibitorLY294002 significantly
inhibited p-Tyr705-STAT3 , p-Ser727-STAT3, and PLGF expression, indicating that Akt is involved in JAK3/STAT3/PLGF signaling cascade