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OTX2 — TYR

Text-mined interactions from Literome

Martínez-Morales et al., J Biol Chem 2003 : OTX2 and MITF co-localize in the nuclei of RPE cells and physically interact, and their co-expression results in a cooperative activation of QNR71 and tyrosinase promoters
Reinisalo et al., Molecular vision 2012 : In the RPE, OTX2 activated the human TYR gene promoter via direct trans-activation of novel OTX2 binding elements ... Overexpression or knockdown of OTX2 in RPE cells resulted in corresponding changes in tyrosinase mRNA expression ... In the RPE, OTX2 activates the human TYR gene promoter by direct DNA binding and by interaction with MITF ... Collectively, these findings emphasize the role of OTX2 in regulating the human TYR gene, with implications for inter-individual differences in melanin synthesis, retinal development, and function as well as susceptibility to retinal degeneration associated with aging