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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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PLCG1 — TYR

Text-mined interactions from Literome

Williams et al., EMBO J 1999 : Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor dependent phospholipase C-gamma1 and Ras activation
Paz et al., Biochem J 2001 : Our results indicate that Tyr ( 226 ) and Tyr ( 191 ) are required for Vav binding, whereas Tyr ( 171 ) and Tyr ( 132 ) are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 respectively
Harita et al., J Biol Chem 2009 (Calcium Signaling) : Upon this clustering, PLC-gamma1 was bound to phosphorylated Nephrin Tyr-1204 , which induced translocation of PLC-gamma1 from cytoplasm to the CD8/Nephrin cluster on the plasma membrane
Loeb et al., J Biol Chem 1994 : Tyr-785 is required for phospholipase C-gamma 1 to interact with Trk and to become tyrosine phosphorylated in response to NGF
Sorokin et al., J Biol Chem 1994 : It has been shown previously that phosphorylation of Tyr-766 is essential for interaction with phospholipase C gamma and that the Y766F FGF receptor mutant is unable to stimulate phosphatidylinositol hydrolysis and Ca2+ release from internal stores
Larose et al., Oncogene 1993 : High-affinity binding of PLC-gamma 1 was dependent on phosphorylation of Tyr-1021
Baxter et al., Eur J Biochem 1995 : Our results demonstrate the following : ( 1 ) the phosphorylation of Tyr490 plays a major role in the activation of inositol phospholipid 3-kinase and formation of 3-phosphorylated inositol lipids and confirm that the phosphorylation of Tyr 785 triggers the activation of phospholipase C-gamma 1 in vivo
Jiang et al., J Biol Chem 1996 (Cell Transformation, Neoplastic) : Our data also suggest that Tyr-1316 is involved in phosphorylation of phospholipase C-gamma , which is, however, not important for cell transforming activity
Fixman et al., J Biol Chem 1996 (Cell Transformation, Neoplastic) : We show here that Tyr489 is also required for association of Tpr-Met with phospholipase Cgamma and the tyrosine phosphatase, SHPTP2/Syp