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PLCG1 — TYR
Text-mined interactions from Literome
Williams et al., EMBO J 1999
:
Phosphorylation of
Tyr319 in ZAP-70 is
required for T-cell antigen receptor dependent
phospholipase C-gamma1 and Ras activation
Paz et al., Biochem J 2001
:
Our results indicate that Tyr ( 226 ) and Tyr ( 191 ) are required for Vav binding, whereas
Tyr ( 171 ) and Tyr ( 132 ) are
necessary for association and activation of phosphoinositide 3-kinase activity and
PLCgamma1 respectively
Harita et al., J Biol Chem 2009
(Calcium Signaling) :
Upon this clustering, PLC-gamma1 was bound to phosphorylated Nephrin
Tyr-1204 , which
induced translocation of
PLC-gamma1 from cytoplasm to the CD8/Nephrin cluster on the plasma membrane
Loeb et al., J Biol Chem 1994
:
Tyr-785 is
required for
phospholipase C-gamma 1 to interact with Trk and to become tyrosine phosphorylated in response to NGF
Sorokin et al., J Biol Chem 1994
:
It has been shown previously that phosphorylation of
Tyr-766 is
essential for interaction with
phospholipase C gamma and that the Y766F FGF receptor mutant is unable to stimulate phosphatidylinositol hydrolysis and Ca2+ release from internal stores
Larose et al., Oncogene 1993
:
High-affinity binding of
PLC-gamma 1 was
dependent on phosphorylation of
Tyr-1021
Baxter et al., Eur J Biochem 1995
:
Our results demonstrate the following : ( 1 ) the phosphorylation of Tyr490 plays a major role in the activation of inositol phospholipid 3-kinase and formation of 3-phosphorylated inositol lipids and confirm that the phosphorylation of
Tyr 785
triggers the activation of
phospholipase C-gamma 1 in vivo
Jiang et al., J Biol Chem 1996
(Cell Transformation, Neoplastic) :
Our data also suggest that
Tyr-1316 is
involved in phosphorylation of
phospholipase C-gamma , which is, however, not important for cell transforming activity
Fixman et al., J Biol Chem 1996
(Cell Transformation, Neoplastic) :
We show here that
Tyr489 is also
required for association of Tpr-Met with
phospholipase Cgamma and the tyrosine phosphatase, SHPTP2/Syp