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Mallon et al., Mol Cancer Ther 2010
:
We are testing whether dual PI3K/mTOR inhibitors can durably suppress p-Akt, induce cleaved PARP , and cause tumor regression in a diverse set of human tumor xenograft models
Son et al., Toxicol Appl Pharmacol 2011
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Consequently, these results suggest that cadmium mediated ROS generation causes PARP activation and energy depletion, and eventually induces autophagy through the activation of LKB1-AMPK signaling and the down-regulation of mTOR in skin epidermal cells